Toll like Receptors in Health and Disease 1st edition by Vijay Kumar 9783031065125 3031065123

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ISBN 10: 3031065123

ISBN 13: 9783031065125

Author:Vijay Kumar  

The current book is focussed on the Toll-like receptors (TLRs), which are the first pattern recognition receptors (PRRs) discovered in humans. For example, TLR4 was first recognized in humans in 1997 as a PRR recognizing the Gram-negative bacterial lipopolysaccharide (LPS). This discovery revolutionized the field of innate immunity and filled the long-standing gap in the pathogen recognition by the immune system. Now, it is well established that humans have 10 (TLR1-TLR10) and mice have 12 (TLR1-TLR13) functional TLRs, excluding TLR10 that is present as a defective pseudogene. TLRs are present as both membrane-bound extracellular (TLR1, TLR2, TLR4, TLR5, TLR6, and TLR10) and intracellular (TLR3, TLR7, TLR8, and TLR9) PRRs in humans, which identify different pathogen or microbe-associated molecular patterns (PAMPs or MAMPs) and death or damage-associated molecular patterns (DAMPs) released by the host cells. A lot of development in the TLR biology has occurred in last 24 years since there first discovery in humans.

The book is intended to describe their role in the host defence, human reproduction, non-infectious sterile inflammatory conditions, including brain immunity and cerebrovascular diseases, signaling mechanisms, adaptive immunity, and their targeting for drug development.

Toll like Receptors in Health and Disease 1st  Table of contents: 

Toll-Like Receptors (TLRs) in Health and Disease: An Overview
Signal-Strength and History-Dependent Innate Immune Memory Dynamics in Health and Disease
Innate Neutrophil Memory Dynamics in Disease Pathogenesis
Cell-Specific Expression Pattern of Toll-Like Receptors and Their Roles in Animal Reproduction
Toll-Like Receptors in Adaptive Immunity
Intracellular TLRs of Mast Cells in Innate and Acquired Immunity
TLR10 and Its Role in Immunity
Toll-Like Receptors in Stem/Progenitor Cells
TLR Signaling in Brain Immunity
Toll-Like Receptor 4 in Pain: Bridging Molecules-to-Cells-to-Systems
Toll-Like Receptor 4: A Novel Target to Tackle Drug Addiction?
Toll-Like Receptors as Drug Targets in the Intestinal Epithelium

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