The Pulmonary Neuroepithelial Body Microenvironment A Multifunctional Unit in the Airway Epithelium 1st Edition by Inge Brouns, Line Verckist, Isabel Pintelon, Jean Pierre Timmermans, Dirk Adriaensen IBSN 3030658171 9783030658175

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ISBN 10: 3030658171 
ISBN 13: 9783030658175
Author: Inge Brouns, Line Verckist, Isabel Pintelon, Jean Pierre Timmermans, Dirk Adriaensen

This monograph sheds new light on pulmonary sensory receptors. Diving into the pulmonary microenvironment, the book focuses on the role of pulmonary neuroepithelial bodies (NEBs) as potential receptors and effectors, able to store and release neurotransmitters. It explores NEBs as potential stem cell niche and highlights the multidisciplinary approach taken to identify and study NEBs, including functional morphological investigation, live cell imaging, genetic models, and laser microdissection combined with gene expression analysis. Complexly organized NEBs are an integral part of the intrapulmonary airway epithelium of all air-breathing vertebrates. For decades a quest has been going on to unravel the functional significance of these intriguing structures that appear to be modified in the course of many pulmonary diseases. The NEB microenvironment (ME) is composed of organoid clusters of pulmonary neuroendocrine cells (PNECs) that are able to store and release neurotransmitters and are closely contacted by extensive nerve terminals, emphasizing a potential receptor/effector role and probable signalling to the central nervous system. PNECs are largely shielded from the airway lumen by a special type of Clara cells, the Clara-like cells, with potential stem cell characteristics. So far, functional studies of the pulmonary NEB ME revealed that PNECs can be activated by various mechanical and chemical stimuli, resulting in a calcium-mediated release of neurotransmitters. In the past decades, a number of publications have exposed NEBs as potential hypoxia sensors. Recent experimental evidence unveiled that the NEB ME is a quiescent stem cell niche in healthy postnatal lungs, and silencing may involve bone morphogenetic protein signalling mediated by vagal afferents. Only an integrated approach that takes all current information into account will be able to explain the full role of the pulmonary NEB ME in health and disease. This highly informative and carefully presented book, provides insights for researchers, PhD students with an interest in (bio)medical and veterinary science, especially in the field of the autonomic innervation of the lung, chemo-and mechanoreceptors.

 The Pulmonary Neuroepithelial Body Microenvironment A Multifunctional Unit in the Airway Epithelium 1st Table of contents:

• The Anatomy of Pulmonary Neuroepithelial Bodies

  • Structure and location of NEBs in the airway epithelium
  • Cellular composition: neuroendocrine cells and their interactions
  • Relationship with surrounding tissues

• Development of the Pulmonary Neuroepithelial Body

  • Embryological development of NEBs
  • Molecular signaling pathways involved in NEB formation
  • Temporal and spatial regulation of NEB development

• Function of Pulmonary Neuroepithelial Bodies

  • Role of NEBs in airway defense
  • Mechanisms of neurotransmitter release and signaling
  • Contribution to airway tone regulation
  • NEBs in response to environmental stimuli (e.g., irritants, pathogens)

• Pulmonary Neuroepithelial Bodies in Disease

  • NEBs in the pathophysiology of respiratory diseases (e.g., asthma, COPD)
  • Changes in NEB structure and function in disease states
  • Potential biomarkers related to NEBs in airway diseases

• Neuroepithelial Bodies and Inflammation

  • Interaction between NEBs and immune cells
  • NEBs in the modulation of inflammatory responses in the airways
  • Role in chronic inflammation and fibrosis

• Pulmonary Neuroepithelial Bodies in Neuroimmune Communication

  • Neuroendocrine signaling within the airway epithelium
  • Neuroimmune interactions and their implications for airway diseases
  • The role of NEBs in the airway neuroimmune system

• Techniques for Studying Pulmonary Neuroepithelial Bodies

  • Imaging techniques for visualizing NEBs
  • Molecular tools to investigate NEB function
  • In vitro and in vivo models for studying NEBs

• Therapeutic Implications

  • Targeting NEBs for treatment of respiratory diseases
  • Drug delivery strategies involving NEB pathways
  • Potential for NEBs in regenerative medicine and tissue repair

• Future Directions in Pulmonary NEB Research

  • Emerging findings and unanswered questions in NEB biology
  • The role of NEBs in lung regeneration and repair
  • Prospects for NEB-targeted therapies

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