The Blood Brain Barrier in Health and Disease 1st edition by Katerina Dorovini Zis ISBN 0367738120 978-0367738129

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ISBN 10: 0367738120 
ISBN 13:  978-0367738129
Author:  Katerina Dorovini Zis 

Located at the interface between blood and the brain, the blood-brain barrier is a dynamic permeability barrier formed by a continuous layer of specialized endothelial cells endowed with important permeability, transport, and regulatory functions that both protect the internal milieu of the brain and allow essential nutrients to be transported into the brain. Over the last 25 years, we have witnessed remarkable expansion of our knowledge of the structure, biology, and function of the cerebral endothelium.

In The Blood-Brain Barrier in Health and Disease, Volume 1, international experts discuss basic and new concepts and most recent advances pertaining to the development of the cerebral microvascular system. Subjects include the structure, function, permeability properties, transport mechanisms, and the inherent heterogeneity of the cerebral endothelium; the anatomy and physiological properties of the neurovascular unit; functional aspects of the choroid plexus; and important concepts and advances made over the last two decades that have shaped our understanding of the immunological function of the blood-brain barrier.

This book is intended to serve as a valuable source of basic and advanced information for researchers, students, and clinicians interested in this fast-expanding field and stimulate further research well into the future.

The Blood-Brain Barrier in Health and Disease 1st Table of contents:

• Introduction to the Blood-Brain Barrier

  • Overview of the blood-brain barrier’s function in maintaining brain homeostasis
  • Historical background and discovery of the BBB
  • Structural components of the BBB (e.g., endothelial cells, tight junctions)

• Physiological Function of the Blood-Brain Barrier

  • Mechanisms of selective permeability and transport across the BBB
  • Role in protecting the brain from toxins and pathogens
  • Nutrient and ion transport systems

• Development of the Blood-Brain Barrier

  • Embryonic development of the BBB
  • Factors influencing BBB formation during early brain development
  • Differences between the developing and mature BBB

• Molecular and Cellular Mechanisms of BBB Function

  • Transporters, receptors, and enzymes at the BBB
  • Role of glial cells (astrocytes, microglia) in BBB integrity and function
  • Signaling pathways regulating BBB permeability

• Disruption of the Blood-Brain Barrier in Disease

  • BBB dysfunction in neurological diseases (e.g., Alzheimer’s disease, multiple sclerosis, stroke)
  • Pathophysiological mechanisms leading to BBB breakdown
  • Impact of BBB disruption on brain function and disease progression

• The Blood-Brain Barrier and Neuroinflammation

  • Inflammatory cytokines and their effects on BBB integrity
  • Neuroimmune interactions and their role in BBB disruption
  • BBB involvement in neurodegenerative diseases and autoimmune disorders

• Blood-Brain Barrier in Stroke

  • Mechanisms of BBB disruption during ischemic stroke
  • Role of the BBB in stroke-induced inflammation and edema
  • Therapeutic strategies to protect or restore the BBB after stroke

• Blood-Brain Barrier in Cancer

  • Role of the BBB in brain tumors (e.g., gliomas, metastasis)
  • Challenges in delivering chemotherapeutic agents across the BBB
  • Advances in strategies to bypass the BBB for cancer treatment

• Therapeutic Approaches to Modulating the Blood-Brain Barrier

  • Strategies for enhancing drug delivery to the brain
  • Techniques for restoring or protecting BBB integrity
  • Use of nanoparticles, liposomes, and other delivery systems

• The Blood-Brain Barrier in Infectious Diseases

  • Mechanisms of BBB disruption in viral, bacterial, and fungal infections
  • Role of the BBB in preventing and controlling CNS infections
  • Case studies (e.g., HIV, bacterial meningitis, neurotropic viruses)

• Emerging Research and Future Directions

  • New technologies for studying the BBB (e.g., imaging techniques, in vitro models)
  • Potential biomarkers for BBB dysfunction
  • The future of BBB-targeted therapies and personalized medicine

• Conclusion

  • Summary of the current understanding of BBB biology and its role in health and disease
  • Ongoing challenges in BBB research
  • Potential future breakthroughs in treatment and prevention

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