Textbook of Nephro Endocrinology 1st Edition by Ajay Singh, Gordon Williams ISBN 0123738709 97

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ISBN 10:       0123738709
ISBN 13: 978-0123738707
Author:         Ajay K. Singh, Gordon H. Williams

The Textbook of Nephro-Endocrinology is the definitive translational reference in the field of nephro-endocrinology, investigating both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems. It offers researchers and clinicians expert, gold-standard analyses of nephro-endocrine research and translation into the treatment of diseases such as anemia, chronic kidney disease (CKD), rickets, osteoporosis, and, hypoparathyroidism.

• Investigates both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems
• Presents a uniquely comprehensive and cross-disciplinary look at all aspects of nephro-endocrine disorders in one reference work
• Clear translational presentations by the top endocrinologists and nephrologists in each specific hormone or functional/systems field

Textbook of Nephro-Endocrinology 1st Table of contents:

PART I: THE KIDNEY AS AN ENDOCRINE ORGAN

Section I: Erythropoietin

Chapter 1: Erythropoietin: An Historical Overview of Physiology, Molecular Biology, and Gene Regulation

• I. Introduction
• II. Hormonal Regulation of Erythropoiesis
• III. Identification of the Site of Erythropoietin Production
• IV. Assays of Erythropoietin
• V. Isolation and Characterization of Erythropoietin
• VI. Erythropoietin Effector Mechanisms
• VII. Regulation of Erythropoiesis by Hypoxia
• VIII. Regulatory Elements of Erythropoietin (EPO) Gene
• IX. Erythropoietin – The Paradigm for Gene Regulation by Hypoxia
• X. Hypoxia Inducible-Factor (HIF)
• XI. The Elusive Nature of the Oxygen Sensor
• XII. Degradation of HIF by the Ubiquitin-Proteosomal Pathway
• XIII. Disruption of the Oxygen-Sensing Pathway in Cancer
• XIV. Disruption of the Oxygen-Sensing Pathway in Hereditary Polycythemia
• XV. Pharmacological Manipulation of HIF
• XVI. Summary
• References

Chapter 2: Erythropoiesis: The Roles of Erythropoietin and Iron

• I. Erythropoiesis: An Overview
• II. Role of Erythropoietin in Erythropoiesis
• III. Role of Iron in Erythropoiesis
• References

Chapter 3: Extra-Hematopoietic Action of Erythropoietin

• I. Introduction
• II. The EPO Receptor (EPOR)
• III. Regulation of EPOR Expression
• IV. Action of EPO
• V. Mechanisms of EPO Action
• VI. Summary
• References

Chapter 4: Development of Recombinant Erythropoietin and Erythropoietin Analogs

• I. Introduction
• II. History of Recombinant Human Erythropoietin
• III. Biosimilar EPOs
• IV. Potential Strategies for Modifying Erythropoietin to Create New EPO Analogs
• V. Darbepoetin Alfa
• VI. Continuous Erythropoietin Receptor Activator (C.E.R.A.)
• VII. Small Molecule ESAs
• VIII. Other Strategies for Stimulating Erythropoiesis
• IX. Conclusions
• References

Chapter 5: Erythropoietin Anemia and Kidney Disease

• I. Introduction
• II. Erythropoietin Pathophysiology in CKD Patients
• III. Anemia of Chronic Kidney Disease
• IV. Anemia and Erythropoietin Treatment in Children with CKD
• V. Conclusions
• References

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Section II: Vitamin D, PTH, and Novel Regulators of Phosphate

Chapter 6: Vitamin D and the Kidney: Introduction and Historical Perspective

• I. Introduction
• II. Vitamin D
• III. Cinacalcet
• References

Chapter 7: Vitamin D: Molecular Biology and Gene Regulation

• I. Vitamin D
• II. The 1,25-Dihydroxyvitamin D/Vitamin D Receptor Complex
• III. Relevance of 1,25-Dihydroxyvitamin D/VDR Actions in Health and in Kidney Disease
• IV. Concluding Remarks
• References

Chapter 8: Molecular Biology of Parathyroid Hormone

• I. Introduction
• II. Biosynthesis and Metabolism
• III. PTH Receptors
• IV. Isoforms
• V. Physiological Actions of PTH
• References

Chapter 9: Endocrine Regulation of Phosphate Homeostasis

• I. Introduction
• II. Phosphate Homeostasis
• III. Renal Phosphate Transport
• IV. Role of Phosphate in the Regulation of Renal Vitamin D Metabolism
• V. Mouse Models with Renal Defects of Phosphate Transport
• VI. Disorders with an Abnormal Regulation of Renal Phosphate Transport
• References

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Section III: Renin–Angiotensin

Chapter 10: The History of the Renin–Angiotensin System

• I. Introduction
• II. The 20th Century
• III. The 21st Century
• IV. The Dream to be Normotensive and Drug-Free
• V. Conclusion
• References

Chapter 11: Molecular Biology of Renin and Regulation of its Gene

• I. Introduction
• II. Production and Activation of Renin
• III. Renin Gene Structure and Regulation
• IV. Renin Gene Mutation and Disease
• V. Future Perspectives
• References

Chapter 12: Physiology and Regulation of the Renin–Angiotensin–Aldosterone System

• I. Introduction
• II. The Classical Circulating Renin–Angiotensin System (RAS)
• III. Renin Biosynthesis and Secretion
• IV. The Renin Receptor
• V. Angiotensin-Converting Enzyme (ACE)
• VI. The ACE-2/Angiotensin (1–7)/Mas Receptor Pathway
• VII. AT1 Receptors
• VIII. AT2 Receptors
• IX. Angiotensin Receptor Heterodimerization
• X. Tissue Renin–Angiotensin Systems
• XI. Intrarenal Renin–Angiotensin System
• XII. Brain Renin–Angiotensin System
• XIII. Vascular Tissue Renin–Angiotensin System
• XIV. Cardiac Renin–Angiotensin System
• XV. Aldosterone and Mineralocorticoid Receptors
• XVI. Clinical Effects of the Renin–Angiotensin–Aldosterone System (RAAS)
• XVII. Summary
• References

Chapter 13: The Renin–Angiotensin–Aldosterone System and the Kidney

• I. Introduction
• II. Historical Background
• III. Overview of the RAS Pathway
• IV. Physiologic Effects of RAS
• V. Renin Inhibitors
• VI. Conclusion
• References

Chapter 14: The Renin–Angiotensin System and the Heart

• I. Introduction
• II. Cardiac RAS: Local Versus Endocrine Origin
• III. RAS Actions at the Cellular Level
• IV. RAS and the Coronary Circulation
• V. Significance of the RAS on Cardiac Function
• VI. Conclusions
• References

Chapter 15: Renin–Angiotensin Blockade: Therapeutic Agents

• I. Introduction
• II. Therapeutic Classes
• III. Pharmacology
• IV. ACE Inhibitors and Angiotensin Receptor Blockers with Other Agents
• V. Select Side-Effects of ACE Inhibitors and Angiotensin-Receptor Blockers
• VI. Summary

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