Systems Biology of Alzheimer’s Disease 1st Edition by Juan Castrillo, Stephen Oliver ISBN 1493926268 9781493926268

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ISBN 10:       1493926268
ISBN 13: 978-1493926268
Author:         Juan I. Castrillo, Stephen G. Oliver

Alzheimer’s disease (AD) and many other neurodegenerative disorders are multifactorial in nature, involving a combination of genomic, epigenomic, network dynamic and environmental factors. A proper investigation requires new integrative Systems Biology approaches, at both the experimental and computational level. The interplay of disease mechanisms and homeostatic networks will underlie the time of onset and rate of progression of the disease.

This book addresses such an integrated approach to AD. It aims to present Systems Biology, including both experimental and computational approaches, as a new strategy for the study of AD and other multifactorial diseases, with the hope that the results will translate into more effective diagnosis and treatment, as well as improved public health policies.

Written for the highly successful Methods in Molecular Biology series, practical and cutting-edge, Systems Biology of Alzheimer’s Disease is intended for post-graduate students, post-doctoral researchers and experts in different fields with an interest in comprehensive Systems Biology strategies applicable to AD and other complex multifactorial diseases (including other neurodegenerative diseases and cancers). This book aims to complement other excellent volumes and monographs on AD that cover fundamental, physiological or medical aspects of the disease.

Systems Biology of Alzheimer’s Disease 1st Table of contents:

Section 1: Introduction to Alzheimer’s Disease

1. Chapter 1: Overview of Alzheimer’s Disease
   • Definition and Epidemiology
   • Risk Factors and Pathophysiology
   • Clinical Features and Diagnosis
   • Progression and Stages of Alzheimer’s Disease

Section 2: Genetic and Molecular Basis of Alzheimer’s Disease

2. Chapter 2: Genetics of Alzheimer’s Disease

   • Genetic Risk Factors
   • Familial and Sporadic Forms
   • The Role of ApoE
   • Gene Expression and Epigenetics

3. Chapter 3: Molecular Pathology of Alzheimer’s Disease

   • Amyloid Beta (Aβ) Pathology
   • Tau Pathology
   • Neuroinflammation and Immune Response
   • Cellular Stress and Dysfunction

Section 3: Systems Biology Approaches to Alzheimer’s Disease

4. Chapter 4: Omics Technologies in Alzheimer’s Disease Research

   • Genomics, Transcriptomics, and Proteomics
   • Metabolomics and Lipidomics
   • Systems Biology and Computational Approaches

5. Chapter 5: Network Biology in Alzheimer’s Disease

   • Gene and Protein Interaction Networks
   • Signaling Pathways Involved in Alzheimer’s Disease
   • Systems-Level Understanding of Pathogenesis

Section 4: Mechanisms of Alzheimer’s Disease Pathogenesis

6. Chapter 6: The Role of Amyloid Beta in Alzheimer’s Disease

   • Amyloid Precursor Protein (APP) Processing
   • Amyloid Plaque Formation and Toxicity
   • Amyloid Cascade Hypothesis

7. Chapter 7: Tau and Neurofibrillary Tangles

   • Tau Protein Function and Hyperphosphorylation
   • Neurofibrillary Tangle Formation
   • Tau-Related Pathways in Neurodegeneration

8. Chapter 8: Neuroinflammation in Alzheimer’s Disease

   • Microglia and Astrocyte Activation
   • Cytokine and Chemokine Signaling
   • Immune System Modulation

9. Chapter 9: Mitochondrial Dysfunction and Alzheimer’s Disease

   • Mitochondrial Dysfunction and Oxidative Stress
   • Mitochondrial-Related Signaling Pathways
   • Implications for Neurodegeneration

Section 5: Therapeutic Strategies and Future Directions

10. Chapter 10: Current Therapeutic Approaches

• Cholinesterase Inhibitors and NMDA Receptor Antagonists
• Anti-Amyloid and Anti-Tau Therapies
• Disease-Modifying Drugs

11. Chapter 11: Emerging Therapies and Drug Development

• Targeting Amyloid and Tau Aggregation
• Immunotherapies and Gene Therapy
• Neuroprotective Strategies

12. Chapter 12: Systems-Based Approaches to Alzheimer’s Disease Treatment

• Personalized Medicine and Biomarker-Based Approaches
• Systems Pharmacology and Drug Repurposing
• Challenges and Future Directions in Treatment

Section 6: Conclusion

13. Chapter 13: Summary and Future Perspectives

• Integrating Systems Biology into Alzheimer’s Disease Research
• Toward a More Comprehensive Understanding of Disease Mechanisms
• Prospects for Effective Treatments and Cure

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