Smooth Muscle Spontaneous Activity Physiological and Pathological Modulation 1st edition by Hikaru Hashitani, Richard Lang ISBN 981135894X 978-9811358944

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ISBN 10: 981135894X 
ISBN 13: 978-9811358944
Author: Hikaru Hashitani, Richard Lang

This book presents the commonality and heterogeneity of the mechanisms underlying smooth muscle spontaneous activity in various smooth muscle organs and in addition discusses their malfunctions in disease and their potential as novel therapeutic targets. To facilitate understanding, the volume is divided into five parts and covers 16 organs: airways, gastrointestinal tract (phasic muscle, tonic muscle), renal pelvis, ureter, urinary bladder, urethra, corporal tissue, prostate, uterus, oviducts, seminal vesicle, artery, vein, microvasculature, and lymphatic vessels. This structure will help readers to comprehend the most up-to-date information on the similarities and differences in the contractile mechanisms driving various smooth muscles as well as their potential manipulations in particular visceral organ pathologies. The vast advancements in gene, electrical recording, and imaging technologies in this field are also discussed, with review of past achievements and consideration oflikely future developments. This book will be of worldwide interest to clinicians, students, and researchers alike.

Smooth Muscle Spontaneous Activity: Physiological and Pathological Modulation 1st Table of contents:

Part I. Gastrointestinal Tract

1. Spontaneous Electrical Activity and Rhythmicity in Gastrointestinal Smooth Muscles

2. Generation of Spontaneous Tone by Gastrointestinal Sphincters

Part II. Urinary Tract

3. Pacemaker Mechanisms Driving Pyeloureteric Peristalsis: Modulatory Role of Interstitial Cells

4. Excitation-Contraction Coupling in Ureteric Smooth Muscle: Mechanisms Driving Ureteric Peristalsis

5. Spontaneous Activity and the Urinary Bladder

6. Spontaneous Activity in Urethral Smooth Muscle

Part III. Reproductive Organs

7. Ion Channels and Intracellular Calcium Signalling in Corpus Cavernosum

8. Generation and Regulation of Spontaneous Contractions in the Prostate

9. Mucosa-Dependent, Stretch-Sensitive Spontaneous Activity in Seminal Vesicle

10. The Myometrium: From Excitation to Contractions and Labour

11. Myosalpinx Contractions Are Essential for Egg Transport Along the Oviduct and Are Disrupted in Reproductive Tract Diseases

Part IV. Blood Vessels

12. Cellular and Ionic Mechanisms of Arterial Vasomotion

13. Venous Vasomotion

14. Role of Pericytes in the Initiation and Propagation of Spontaneous Activity in the Microvasculature

15. Lymphatic Vessel Pumping

Part V. Airways

16. Regulation of Airway Smooth Muscle Contraction in Health and Disease

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