Salivary Glands Development Adaptions and Disease 1st Edition by Karger AG, AS Tucker, Miletich, Sharpe – Ebook PDF Instant Download/Delivery. 9783805594073 ,3805594070
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ISBN 10: 3805594070
ISBN 13: 9783805594073
Author: Karger AG, AS Tucker, Miletich, Sharpe
Salivary glands are of utmost importance for several physiological functions ranging from the protection of teeth and surrounding soft tissues to the lubrication of the oral cavity, which is crucial for speech and perception of food taste. This publication highlights specific aspects of salivary gland development, investigating the mechanisms involved in embryonic development, the current research in stem cells, the ability of adult glands to regenerate and the signalling pathways involved in this process. Key stages of salivary gland development, moving from initiation to differentiation of the glands, are discussed, as well as unusual adaptations, ranging from making silk to making venom. The book finally provides new data on surgical techniques and diagnostic tools for clinicians involved in salivary gland disorders. Researchers and students with an interest in craniofacial sciences as well as clinicians dealing with salivary gland disorders will find this publication an excellent source of up-to-date information.
Salivary Glands Development Adaptions and Disease 1st Edition Table of contents:
- Salivary Glands as Multifunctional Organs
- Structures and Cell Types of Adult Salivary Glands
- Different Salivary Glands, in Different Locations
- Control of Saliva Production
- The Mouse Submandibular Gland as a Model for Vertebrate Salivary Gland Development
- Early Embryonic Development of Salivary Glands: Initial Bud Formation
- Forming Branches to Escape Space Constraints
- Turning Solid Epithelial Chords into Hollow Tubes
- Conclusions and Perspectives
- Rerefrences
- Salivary Gland Adaptations: Modification of the Glands for Novel Uses
- Abstract
- Silk Production
- Nest Formation
- Venom Production
- Venomous Saliva in Mammals
- Evolution of the Venom System in Reptiles
- Interactions of Glands and Teeth in the Reptilian Venom System
- Conclusions
- Acknowledgement
- Rerefrences
- Genetic Regulation of Salivary Gland Development in Drosophila melanogaster
- Abstract
- Salivary Gland Invagination
- Salivary Gland Lumen Elongation
- Salivary Gland Migration
- Axon Guidance Cues in Salivary Gland Migration
- Salivary Gland Mutagenesis Screens
- Conclusion
- Rerefrences
- Extracellular Matrix and Growth Factors in Salivary Gland Development
- Abstract
- Three-Dimensional Cell and Tissue Models
- Collagen
- Laminin
- Nidogen
- Epimorphin
- Tenascin C
- Proteoglycans
- Fibronectin
- Integrins
- Non-Integrin ECM Receptors
- Growth Factor Signaling
- Proteases and Protease Inhibitors
- Exogenous Matrices and Tissue Engineering
- ECM Alterations in Sjögren‘s Syndrome
- ECM in Salivary Neoplasms
- Future Directions
- Acknowledgements
- Rerefrences
- Lumen Formation in Salivary Gland Development
- Abstract
- The Histology of Lumen Formation
- Creating a Space
- Lining the Lumen: Cell-Cell Junctions
- Tight Junctions
- Adherens Junctions
- Apicobasal Polarity
- Future Research
- Rerefrences
- Epithelial Stem/Progenitor Cells in the Embryonic Mouse Submandibular Gland
- Abstract
- Adult Salivary Gland Stem/Progenitor Cells
- Embryonic Salivary Gland Stem/Progenitor Cells
- SMG Expresses TFs Involved in Embryonic Stem Cell Self-Renewal
- ETS and Sox-Related Transcription Factors are Expressed in the Epithelial End Bud
- SMG Epithelia Contain Basal Progenitor Cells
- Influence of Mesenchyme-Produced Growth Factors on Progenitor Cell Fate Decisions
- Different ES-Related Maintenance Genes Are Downregulated by FGFs
- FGF7 and FGF10 Control Bud-Related Maintenance/Differentiation Genes
- Basal Cells Are Regulated by TGF-βs
- Conclusion
- Rerefrences
- Salivary Gland Regeneration
- Abstract
- Clinical Need
- Salivary Glands Are Highly Adaptable
- Animal Models of Glandular Atrophy and Regeneration
- Mechanisms of Maintaining Gland Size
- Evidence for Regeneration following an Embryonic-Like Pathway
- The Bioinformatics Approach to Studying Signalling Pathways in Regenerating Glands
- MAPKs Signalling Pathway
- Notch Signalling Pathway
- Wnt Signalling Pathway
- Stem Cell Therapies to Regenerate Salivary Glands
- Bioengineering of Salivary Glands
- Conclusions
- Acknowledgements
- Rerefrences
- Salivary Gland Disease
- Abstract
- Salivary Gland Obstructive Disease
- Salivary Gland Calculi
- Treatment Modalities for Stone Removal
- Management of Strictures
- Tumours of the Salivary Glands
- Incidence
- Distribution by Site of Benign and Malignant Salivary Gland Tumours
- Histological Tumour Types
- Management
- Sjögren’s Syndrome
- Discussion
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