Precision Molecular Pathology of Lung Cancer 1st edition by Philip Cagle, Timothy Craig Allen, Mary Beth Beasley, Lucian Chirieac, Sanja Dacic, Alain Borczuk, Keith Kerr, Lynette Sholl, Bryce Portier, Eric Bernicker ISBN 3319629409 ‎ 978-3319629407

Precision Molecular Pathology of Lung Cancer 1st edition by Philip Cagle, Timothy Craig Allen, Mary Beth Beasley, Lucian Chirieac, Sanja Dacic, Alain Borczuk, Keith Kerr, Lynette Sholl, Bryce Portier, Eric Bernicker   – Ebook PDF Instant Download/Delivery. 3319629409 ‎ 978-3319629407
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Product details:

ISBN 10: 3319629409 ‎ 
ISBN 13: ‎ 978-3319629407
Author: Philip Cagle, Timothy Craig Allen, Mary Beth Beasley, Lucian Chirieac, Sanja Dacic, Alain Borczuk, Keith Kerr, Lynette Sholl, Bryce Portier, Eric Bernicker

This new edition provides the latest information and insights into the molecular basis for lung cancer. Since the publication of the previous edition of this volume, dramatic changes have occurred with the classification of lung cancer, biomarker testing, and molecular therapy. The book covers these changes, providing updates and new insights on the background of lung cancer, testing methods, and the molecular pathology of specific cell types, including adenocarcinoma, squamous cell carcinoma, small cell carcinoma, and precursor and preinvasive lesions.
Authored by experts in the field, Precision Molecular Pathology of Lung Cancer, Second Edition remains one of the few books that comprehensively covers the new molecular pathology of lung cancer and is a valuable resource for pathologists, medical oncologists, radiation oncologists, thoracic surgeons, and thoracic radiologists.

Precision Molecular Pathology of Lung Cancer 1st Table of contents:

Part I: Introduction to Lung Cancer and Precision Medicine

1. Overview of Lung Cancer
   • Epidemiology and Risk Factors
   • Classification of Lung Cancer: Non-Small Cell Lung Cancer (NSCLC) and Small Cell Lung Cancer (SCLC)
   • Clinical Features and Staging of Lung Cancer
2. Precision Medicine in Oncology
   • Principles of Precision Medicine
   • The Role of Molecular Pathology in Lung Cancer
   • Advances in Genomic Technologies and Their Impact on Cancer Treatment

Part II: Molecular Pathology of Lung Cancer

3. Genetic Alterations in Lung Cancer
   • Somatic Mutations: EGFR, KRAS, ALK, ROS1, and Others
   • Tumor Suppressor Genes: TP53, LKB1, and STK11
   • Oncogenes and Their Role in Lung Cancer Pathogenesis
4. Molecular Subtypes of Lung Cancer
   • Subtypes of Non-Small Cell Lung Cancer: Adenocarcinoma, Squamous Cell Carcinoma, and Large Cell Carcinoma
   • Small Cell Lung Cancer and Its Molecular Characteristics
   • Rare and Variant Forms of Lung Cancer
5. Molecular Alterations in Tumor Microenvironment
   • Role of Tumor Microenvironment in Lung Cancer Progression
   • Genetic and Epigenetic Modifications in the Microenvironment
   • Interaction Between Tumor Cells and Immune Cells

Part III: Diagnostic Approaches in Molecular Pathology

6. Molecular Diagnostics in Lung Cancer
   • Diagnostic Techniques: PCR, Next-Generation Sequencing (NGS), FISH, and IHC
   • Biomarkers for Lung Cancer Diagnosis and Prognosis
   • Liquid Biopsy in Lung Cancer: Circulating Tumor DNA and RNA
7. Histopathology and Molecular Correlation
   • Histopathological Features of NSCLC and SCLC
   • Correlating Molecular Findings with Histological Diagnosis
   • Molecular Testing for Targeted Therapy and Immunotherapy
8. Genetic Profiling in Lung Cancer
   • Comprehensive Genomic Profiling in Lung Cancer
   • Identification of Driver Mutations and Therapeutic Targets
   • Clinical Utility and Challenges of Genomic Testing in Lung Cancer

Part IV: Targeted Therapy in Lung Cancer

9. Targeted Therapies for EGFR Mutations
   • Mechanisms of Action of EGFR Inhibitors
   • Clinical Use of EGFR-TKIs: First-Generation to Third-Generation Inhibitors
   • Resistance Mechanisms and Management
10. Targeted Therapies for ALK and ROS1 Rearrangements
    • Role of ALK and ROS1 in Lung Cancer Pathogenesis
    • Tyrosine Kinase Inhibitors for ALK/ROS1-Positive Lung Cancer
    • Resistance Mechanisms and Novel Agents
11. Targeted Therapies for KRAS Mutations
    • KRAS as a Driver Mutation in Lung Cancer
    • Targeting KRAS with Small Molecule Inhibitors
    • Clinical Implications and Challenges
12. Other Targeted Therapies in Lung Cancer
    • BRAF Inhibitors in Lung Cancer
    • RET Inhibitors: Targeting RET Fusions
    • MET Amplification and Therapies

Part V: Immunotherapy in Lung Cancer

13. Immunotherapy in Lung Cancer
    • Principles of Cancer Immunotherapy
    • Immune Checkpoint Inhibitors: PD-1, PD-L1, and CTLA-4 Inhibition
    • Biomarkers for Immunotherapy Response in Lung Cancer
14. Combining Targeted Therapy and Immunotherapy
    • Rational Combination of Targeted Agents with Immune Checkpoint Inhibitors
    • Clinical Trials and Emerging Data on Combination Therapies
    • Challenges and Future Directions in Combined Therapy
15. Predictive Biomarkers for Immunotherapy
    • Role of PD-L1 Expression and Tumor Mutational Burden (TMB)
    • Genetic Profiling and Predicting Immunotherapy Response
    • Evaluating the Efficacy of Immunotherapy in NSCLC and SCLC

Part VI: Resistance Mechanisms and Future Directions

16. Mechanisms of Resistance to Targeted Therapy
    • Primary vs. Acquired Resistance Mechanisms
    • Alterations in Target Genes and Bypass Signaling Pathways
    • Overcoming Resistance: Next-Generation Therapies and Combination Strategies
17. Mechanisms of Resistance to Immunotherapy
    • Immune Evasion Mechanisms in Lung Cancer
    • Resistance to PD-1/PD-L1 Inhibitors and CTLA-4 Blockade
    • Emerging Strategies to Overcome Immunotherapy Resistance
18. Emerging Trends in Lung Cancer Treatment
    • Liquid Biopsy for Real-Time Monitoring of Resistance
    • The Role of Artificial Intelligence in Molecular Pathology and Therapy Selection
    • Future Directions in Personalized Lung Cancer Therapy

Part VII: Clinical Application and Case Studies

19. Clinical Decision Making Based on Molecular Profiling
    • Integrating Molecular Data into Treatment Plans
    • Personalized Approaches to Lung Cancer Treatment
    • Case Studies of Molecular Profiling in Clinical Practice
20. Challenges in Implementing Precision Medicine
    • Barriers to Widespread Adoption of Genomic Testing
    • Cost, Access, and Ethical Considerations in Precision Medicine
    • Clinical Guidelines and Best Practices for Molecular Pathology in Lung Cancer

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