Precision Haematological Cancer Medicine 1st edition by Tariq Mughal 9781498747011 1498747019
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Authors:Tariq Mughal , Series:Medicine [61] , Author sort:Mughal, Tariq , Languages:Languages:eng , Published:Published:Sep 2018 , Publisher:CRC Press
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ISBN 10: 1498747019
ISBN 13: 9781498747011
Author: Tariq Mughal
Many experts now consider genetic evaluation to be pivotal for the optimal diagnosis, classification, risk stratification, and therapeutic decision-making for persons diagnosed with blood cancer. This new text specifically focuses on the genetic alterations essential for establishing diagnosis and assesses how they might impact the precision oncology standard of care. Providing an authoritative review of the state of the art, this is essential reading for physicians, hematologists, and oncologists for optimal management of individual patients.
Precision Haematological Cancer Medicine 1st Table of contents:
Chapter 1: Precision Medicine and Future Therapeutics
- Genetics and the Genomics of Cancer
- Cancer Pathogenesis
- Clonal and Subclonal Events in Cancer Evolution
- Cell Cycle
- Cancer Genomic Assays
Chapter 2: Classifications and Risk Factors
- The WHO Classification of Myeloid and Lymphoid Neoplasms
- Leukaemias, Lymphomas, Myelomas
- Risks Factors: Infection, Radiation, Chemicals, Germline Mutations, Lifestyle
Chapter 3: Historical Milestones
- Biological and Therapeutic Milestones (16th Century to 21st Century)
Chapter 4: Acute Myeloid Leukaemia
- Epidemiology and Aetiology
- Clinical Features, Classification, Diagnosis
- Genetics and Risk Stratification
- Treatment: Remission Induction, Stem Cell Transplantation, Investigational Agents
Chapter 5: Acute Lymphoblastic Leukaemia
- Epidemiology and Aetiology
- Genetics, Risk Stratification, and Treatment Approaches
- Relapsed Disease
Chapter 6: Chronic Myeloid Leukaemia
- Molecular Pathogenesis and Genetics
- Risk Stratification, TKIs, and Investigational Approaches
Chapter 7: Myeloproliferative and Related Neoplasms
- Polycythaemia Vera, Essential Thrombocythaemia, Myelofibrosis
- Atypical Neoplasms: Chronic Neutrophilic and Eosinophilic Leukaemia, Mastocytosis
Chapter 8: Myelodysplastic Syndromes and Myelodysplastic/Myeloproliferative Neoplasms
- Myelodysplastic Syndromes: Epidemiology, Genetics, Risk Assessment
- Myelodysplastic/Myeloproliferative Neoplasms: Subtypes and Transformation to AML
Chapter 9: Leukaemias of Mature B- and T/NK-Cells
- Chronic Lymphocytic Leukaemia
- Hairy Cell Leukaemia, Prolymphocytic Leukaemia
Chapter 10: Hodgkin Lymphoma
- Classification, Prognosis, and Treatment
- Investigational Therapies
Chapter 11: Non-Hodgkin Lymphoma
- Classification and Subtypes: Diffuse Large B-Cell, Follicular, Peripheral T-Cell, Burkitt’s Lymphoma
Chapter 12: Plasma Cell Neoplasms
- Multiple Myeloma: Staging, Treatment, and Investigational Therapies
- Smouldering Multiple Myeloma, Monoclonal Gammopathy, Systemic Amyloidosis
Chapter 13: Principal Treatment-Related Side Effects
- Immune-Related Adverse Events, Cardiovascular, Gastrointestinal, and Neurological Toxicities
- Radiotherapy and Late Effects
Chapter 14: Concluding Thoughts
- Final Reflections on Progress and Future Directions
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