Practical Hepatic Pathology A Diagnostic 2nd edition by Romil Saxena ISBN 0323428738 978-0323428736

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ISBN 10: 0323428738 
ISBN 13: 978-0323428736
Author:  Romil Saxena 

A volume in the popular Pattern Recognition Series, Practical Hepatic Pathology: A Diagnostic Approach features completely updated and reorganized content, resulting in a truly practical guide to understanding liver pathology. Dr. Romil Saxena presents interpretation of liver biopsies according to a pattern-based approach that begins with recognition of the predominant histological pattern of injury, followed by identification of secondary features and appropriate work-up that lead you away from pitfalls to the best diagnosis.

Practical Hepatic Pathology A Diagnostic 2nd Table of contents:

Part I: Introduction to Hepatic Pathology

1. Overview of Liver Anatomy and Function
   • Basic Anatomy of the Liver
   • Functions of the Liver: Metabolism, Detoxification, and Protein Synthesis
   • Overview of Hepatic Histology and Pathology
2. Approach to the Diagnosis of Liver Disease
   • Clinical Evaluation of Liver Disease
   • Imaging and Laboratory Findings in Hepatic Pathology
   • Role of Biopsy and Histopathology in Diagnosis

Part II: General Principles of Hepatic Pathology

3. Histopathology of the Liver
   • Normal Liver Histology and Cellular Architecture
   • Key Histological Features in Hepatic Diseases
   • Common Stains and Immunohistochemical Markers in Liver Pathology
4. Liver Inflammation and Fibrosis
   • Acute vs. Chronic Inflammation in the Liver
   • Mechanisms and Pathogenesis of Liver Fibrosis
   • Scoring Systems for Liver Fibrosis (e.g., METAVIR, Ishak)
   • Histopathologic Features of Hepatic Inflammation and Fibrosis

Part III: Infectious Diseases of the Liver

5. Viral Hepatitis
   • Hepatitis A, B, C, D, and E: Pathogenesis and Histopathology
   • Chronic Hepatitis B and C: Diagnosis and Liver Histology
   • The Role of Biopsy in Assessing Chronic Hepatitis
6. Bacterial and Parasitic Infections
   • Liver Abscess: Pathogenesis and Histopathology
   • Schistosomiasis, Amoebiasis, and Other Parasitic Infections
   • Bacterial Infections of the Liver: Tuberculosis and Other Causes
7. Fungal and Mycobacterial Infections
   • Fungal Infections: Histopathology of Candidiasis, Aspergillosis, and Histoplasmosis
   • Mycobacterial Infections of the Liver: Granulomas and Hepatic Tuberculosis

Part IV: Non-Infectious Hepatic Disorders

8. Fatty Liver Disease
   • Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH)
   • Alcoholic Fatty Liver Disease: Pathogenesis and Histology
   • Fatty Liver Disease and Its Progression to Cirrhosis
9. Cholestatic Liver Diseases
   • Primary Biliary Cirrhosis (Primary Biliary Cholangitis): Pathology and Diagnosis
   • Primary Sclerosing Cholangitis: Histological Features and Diagnosis
   • Other Cholestatic Disorders: Drug-Induced Liver Injury and Genetic Diseases
10. Liver Cirrhosis and Its Complications
    • Pathogenesis and Staging of Cirrhosis
    • Complications of Cirrhosis: Portal Hypertension, Varices, and Hepatic Encephalopathy
    • Histopathology of Cirrhosis and Its Variants

Part V: Hepatic Neoplasms

11. Benign Liver Tumors
    • Hepatic Hemangioma: Clinical and Pathologic Features
    • Focal Nodular Hyperplasia and Hepatic Adenoma
    • Diagnostic Criteria and Differential Diagnosis
12. Primary Malignant Liver Tumors
    • Hepatocellular Carcinoma (HCC): Pathology, Diagnosis, and Staging
    • Cholangiocarcinoma: Intrahepatic and Extrahepatic Forms
    • Hepatoblastoma: Pediatric Liver Cancer and Its Diagnosis
13. Metastatic Liver Tumors
    • Common Primary Sites of Liver Metastases
    • Histopathology of Metastatic Cancer in the Liver
    • Diagnostic Approaches and Differential Diagnosis of Metastases
14. Liver Tumor Biopsy: Challenges and Considerations
    • Indications and Techniques for Liver Biopsy
    • Histological Evaluation of Liver Tumors
    • Role of Immunohistochemistry and Molecular Diagnostics

Part VI: Genetic and Autoimmune Hepatic Disorders

15. Genetic Disorders of the Liver
    • Hemochromatosis: Pathogenesis, Histopathology, and Diagnosis
    • Wilson’s Disease: Copper Metabolism and Liver Pathology
    • Alpha-1 Antitrypsin Deficiency and Its Hepatic Manifestations
16. Autoimmune Hepatitis
    • Pathogenesis and Diagnostic Criteria for Autoimmune Hepatitis
    • Histopathological Features of Autoimmune Hepatitis
    • Role of Genetic Factors and Autoantibodies in Diagnosis

Part VII: Special Hepatic Pathologies

17. Liver Transplantation and Its Pathology
    • Indications for Liver Transplantation
    • Histopathology of Liver Transplantation: Rejection and Graft Dysfunction
    • Post-Transplant Hepatic Disorders and Complications
18. Liver Pathology in Pregnancy
    • Pregnancy-Associated Liver Diseases: Intrahepatic Cholestasis, Preeclampsia
    • Acute Fatty Liver of Pregnancy: Pathogenesis and Histology
19. Toxic and Drug-Induced Liver Injury
    • Mechanisms of Drug-Induced Liver Injury
    • Histopathological Features of Drug Toxicity
    • Common Drugs and Their Hepatotoxic Effects

Part VIII: Advanced Topics in Hepatic Pathology

20. Molecular Pathology in Hepatic Disease
    • Advances in Molecular Diagnostics for Hepatic Pathology
    • Genetic Mutations and Their Role in Hepatic Diseases
    • Biomarkers for Diagnosis and Prognosis of Liver Disease
21. Emerging Liver Diseases
    • New and Emerging Hepatic Pathologies
    • Viral Hepatitis E and Other Novel Infections
    • Emerging Technologies in Hepatic Pathology

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