Plasma Cell Neoplasms A Morphologic Cytogenetic and Immunophenotypic Approach 1st Edition by Michael A Linden, Robert W McKenna ISBN 3319109189 9783319109183

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ISBN 10: 3319109189 
ISBN 13: 9783319109183
Author: Michael A Linden, Robert W McKenna

This textbook will provide a comprehensive, state-of-the art review the field of diagnostic hematopathology as it’s applied to patients with plasma cell neoplasms. Particular emphasis will be placed on immunophenotypic data – immunohistochemistry and flow cytometry – as well as cytogenetics. We will also discuss how these ancillary data can predict prognosis and chemotherapeutic response. Plasma Cell Neoplasms will serve as a very useful resource for physicians and researchers interested in the plasma cell myeloma diagnosis, therapy, and research. It will provide a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters will be written by experts in their fields and will include the most up to date scientific and clinical information.

Plasma Cell Neoplasms A Morphologic, Cytogenetic and Immunophenotypic Approach 1st Table of contents:

Clinical Protein and Immunofixation Electrophoresis
Introduction
Immunoglobulins
History of Electrophoresis
Clinical Electrophoresis
Principles
Gel Electrophoresis
Capillary Electrophoresis
Protein Patterns
Serum
Urine
Clonal Characterization
Immunofixation—Gel Electrophoresis
Immunosubtraction—Capillary Electrophoresis
Commercial Platforms
Specimen Considerations
Serum
Urine
Reporting and Interpretation
M-Spike Identification and Quantification
Interpretations
Personnel
Additional Considerations
Correlation with Other Laboratory Results
Oligoclonal Responses to Therapy
Monoclonal Antibody Therapeutics
Conclusion
References
Serum Free Light Chain Analysis
Introduction
History of Free Light Chain Detection
Kinetics of Free Light Chains
Serum Free Light Chain Quantification
Analytical Methodologies
Specimen Considerations
Reference Ranges
Interpretation of Serum Free Light Chain Analysis
Clinical Utility of Serum Free Light Chain Analysis
Limitations and Challenges
References
Plasma Cell Neoplasms: Morphology and Immunohistochemistry
Plasma Cell Myeloma
Blood Smear and Bone Marrow Findings
Histopathology
Immunohistochemistry
Monoclonal Gammopathy of Undetermined Significance
Blood and Bone Marrow Findings
Immunohistochemistry
Plasmacytoma
Solitary Plasmacytoma of Bone
Extraosseous Plasmacytoma
Immunoglobulin Deposition Diseases
Primary Amyloidosis
Blood and Bone Marrow Findings
Other Tissues
Histochemistry—Immunohistochemistry
Systemic Light and Heavy Chain Deposition Diseases
Osteosclerotic Myeloma (POEMS Syndrome)
Blood and Bone Marrow Findings
References
Classification of Plasma Cell Neoplasms
Introduction
Monoclonal Gammopathy of Undetermined Significance (MGUS)
Non-IgM MGUS
IgM MGUS
Plasma Cell Myeloma (PCM)
Symptomatic Plasma Cell Myeloma
Asymptomatic Plasma Cell Myeloma
Nonsecretory Myeloma
Plasma Cell Leukemia
Plasmacytoma
Solitary Plasmacytoma of Bone
Extraosseous (Extramedullary) Plasmacytoma
Immunoglobulin Deposition Diseases
Primary Amyloidosis
Monoclonal Light and Heavy Chain Deposition Diseases
Plasma Cell Neoplasms Associated with a Paraneoplastic Syndrome
POEMS Syndrome (Osteosclerotic Myeloma)
TEMPI Syndrome (Provisional Entity)
References
Conventional and Molecular Cytogenetics in Plasma Cell Neoplasms
Introduction
Techniques
Conventional Cytogenetic Analysis (G-banding)
Molecular Cytogenetic Analysis (FISH)
Oligonucleotide Comparative Genomic Hybridization (CGH) and SNP (Single Nucleotide Polymorphism) Arr
Gene Expression Arrays
Next-Generation Sequencing
Genomic Abnormalities
Primary Abnormalities
Hyperdiploid
Nonhyperdiploid
IGH Translocations
Clinical Correlations
Secondary Abnormalities
Monosomy 13 (~ 85 %)/Deletion(13q) (~ 15 %)
Deletion(17p)
Deletion(1p)
Gain or Amplification of 1q
MYC and Other IGH Rearrangements
Gene Mutations
Risk Stratification
Individualized Therapy
Practical Aspects for Genetic Testing in Plasma Cell Neoplasms
Conclusion
References
Role of Flow Cytometry in Plasma Cell Neoplasms
Background
Role of Flow Cytometry for Clonal Plasma Cell Neoplasms
Technical Issues in Plasma Cell Enumeration
Application of Flow Cytometry in Various Types of Plasma Cell Neoplasms
Emerging Markers—Clues from Pre-clinical Models
Summary/Conclusions
References
Plasma Cell Neoplasms, A Therapeutic Approach
Introduction
Clinical and Diagnostic Findings of Solitary Plasmacytomas
Clinical and Diagnostic Findings of AL Amyloidosis
Clinical and Diagnostic Findings of POEMS Syndrome
Clinical and Diagnostic Findings of MGUS and Asymptomatic MM
Monitoring of MGUS and Asymptomatic MM
Clinical and Diagnostic Findings of MM
Determining Transplant Eligibility
Risk Stratification and Prognosis
Monitoring of MM
Treatment of Transplant Eligible Patients
Lenalidomide and Dexamethasone (RD)
Thalidomide and Dexamethasone (TD)
Bortezomib-Based Regimens
Treatment of Transplant Ineligible Patients
Melphalan, Prednisone, Thalidomide (MPT)
Bortezomib, Melphalan, Prednisone (VMP)
Bortezomib, Thalidomide, Prednisone
Melphalan, Prednisone, Lenalidomide (MPR)
Lenalidomide and Low-Dose Dexamethasone
Maintenance Therapies
Thalidomide
Lenalidomide
Bortezomib
Relapsed/Refractory Therapies
Chemotherapy and HSCT
IMiDs
PIs
Histone Deacetylase Inhibitors (HDACs)
Immune-Based Therapies
Alkylators
Solitary Plasmacytoma Treatment
Immunoglobulin Light Chain Amyloidosis Treatment
POEMS Syndrome Treatment
Summary
References
Standardized Synoptic Reports for Plasma Cell Neoplasms: Integration of Laboratory and Clinical Data
Clinical Information/Ancillary Laboratory Data
WHO Classification
Peripheral Smear Evaluation
Bone Marrow Aspirate/Bone Marrow Trephine Biopsy
Additional Morphologic Findings

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