Pharmacology and Physiology for Anesthesia Foundations and Clinical Application 2nd edition by Hugh Hemmings, Talmage Egan ISBN 0323481108 978-0323481106

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ISBN 10: 0323481108 
ISBN 13: 978-0323481106
Author: Hugh Hemmings, Talmage Egan

Pharmacology and physiology are the foundation of every anesthesia provider’s training and clinical competency. Pharmacology and Physiology for Anesthesia: Foundations and Clinical Application, 2nd Edition, delivers the information you need in pharmacology, physiology, and molecular-cellular biology, keeping you current with contemporary training and practice. This thoroughly updated edition is your one-stop, comprehensive overview of physiology, and rational anesthetic drug selection and administration, perfect for study, review, and successful practice.

• Contains new chapters on Special Populations (anesthetic pharmacology in obesity, geriatrics, and pediatrics), Oral and Non-IV Opioids, Thermoregulation, Physiology and Pharmacology of Obstetric Anesthesia, Chemotherapeutic and Immunosuppresive Drugs, and Surgical Infection and Antimicrobial Drugs.
• Incorporates entirely new sections on Physics, Anatomy, and Imaging.
• Includes new information on consciousness and cognition, pharmacodynamics, the immune system, and anti-inflammatory drugs.
• Features user-friendly tables, figures, and algorithms (including 100 new illustrations), all presented in full color and designed to help explain complex concepts.
• Helps you understand the molecular mechanism of drug actions and identify key drug interactions that may complicate anesthesia with dedicated sections on these areas.
• Expert Consult™ eBook version included with purchase, which allows you to search all of the text, figures, and references from the book on a variety of devices

Pharmacology and Physiology for Anesthesia Foundations and Clinical Application 2nd Table of contents:

Section I: Basic Principles of Pharmacology

This section introduces the fundamental concepts of pharmacology, including how drugs work (mechanisms of action), drug absorption, distribution, metabolism, and excretion (pharmacokinetics), and drug effects on the body (pharmacodynamics). Key topics include:

• Drug Discovery and novel antidotes.

• Pharmacokinetics of intravenous and inhaled anesthetics.

• Drug interactions, adverse drug reactions, and pharmacogenetics that influence drug responses in different patient populations (e.g., obese, pediatric, and elderly).

• Metabolism and drug interactions, particularly in anesthesia.

Section II: Nervous System

This section covers the physiology and pharmacology related to the central nervous system (CNS), including:

• CNS Physiology: Structure and function of the brain, cerebrovascular anatomy, and cerebrospinal fluid dynamics.

• Pharmacology of Anesthetics: Mechanisms of action of intravenous and inhaled anesthetics, opioid and nonopioid analgesics, and drugs for neuropsychiatric disorders.

• Autonomic Nervous System: Effects on anesthesia, pharmacology of adrenergic and parasympathetic receptors, and their role in anesthesia and disease.

Section III: Cardiovascular System

This section discusses the pharmacology of drugs acting on the heart and blood vessels:

• Cardiovascular Physiology: Cardiac function, vascular regulation, and hemodynamics.

• Pharmacology of Vasopressors, Inotropes, Antihypertensive Drugs, and Antiarrhythmic Drugs: Mechanisms, clinical uses, and pharmacodynamics.

• Cardiopulmonary Resuscitation: Overview of emergency interventions and therapeutic strategies.

Section IV: Pulmonary System

This section addresses pulmonary physiology and pharmacology:

• Pulmonary Ventilation and Oxygenation: Regulation of pulmonary function and blood oxygen levels.

• Pharmacology: Drugs used for bronchodilation, corticosteroids, and other treatments for respiratory diseases, as well as anesthetic agents affecting the pulmonary system.

Section V: Gastrointestinal and Endocrine Systems

This section explores the pharmacology of the gastrointestinal and endocrine systems:

• Liver and Gastrointestinal Pharmacology: Liver function, gastrointestinal drugs, and their pharmacological effects.

• Endocrine Physiology and Pharmacology: Drugs that treat endocrine disorders, including those for the hypothalamic-pituitary-end-organ axis and metabolic diseases.

Section VI: Immunity and Infection

This section highlights the pharmacology related to infections and immune modulation:

• Chemotherapy and Immunosuppression: Effects of anesthesia on cancer and drugs for immune modulation.

• Infection and Antimicrobial Drugs: Perioperative antimicrobial prophylaxis and selection of drugs for infections in the surgical context.

Section VII: Fluid, Electrolyte, and Hematologic Homeostasis

This section discusses fluid management, electrolyte balance, and hematology:

• Renal Physiology and Pharmacology: Kidney function, water and electrolyte balance, and drug impacts on renal function.

• Electrolytes and Diuretics: The role of electrolytes like potassium and calcium in drug therapy.

• Blood and Coagulation: Hemostasis, transfusion, and management of bleeding during anesthesia.

Section VIII: Blood and Hemostasis

This section addresses blood coagulation and transfusion:

• Hemostasis and Coagulation Therapy: The body’s mechanisms for stopping bleeding, coagulation therapies, and blood conservation.

• Anticoagulant and Antiplatelet Therapy: Mechanisms and therapies to manage blood clotting, both in the perioperative and critical care settings.

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