PET Studies on Amino Acid Metabolism and Protein Synthesis 1st Edition by Lajtha, Dunlop, Banay Schwartz, Mazoyer, Heiss, Comar ISBN 9789401116206 940111620X

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Product details:
ISBN 10: 940111620X
ISBN 13: 9789401116206 
Author: Lajtha, Dunlop, Banay Schwartz, Mazoyer, Heiss, Comar

Parameters such as membrane transport, metabolism and protein incorporation govern the fate of amino acids in living tissue. Is it possible to use positron tomography to measure some of them, and what is their meaning in normal and pathological situations? These questions have been addressed for a long time and no satisfactory answer has yet been given.
This book, which derives from an EEC workshop organized in the frame of the Concerted Action on `PET Investigation of Cellular Regeneration and Degeneration’, held in Lyon in February 1992, gives the present state of knowledge in this field based on the most recent studies. Contributions from 24 leading European and American scientists are presented and discussed in the following four parts:

• biochemistry and animal studies;
• amino acids labelling with positron emittors, quality control and metabolites measurement;
• kinetic modelling of amino acids transport, metabolism, and protein incorporation;
• clinical use of amino acids.

This book will aid and interest biochemists, radiochemists, pharmacologists, neurologists, oncologists and medical imaging scientists.

PET Studies on Amino Acid Metabolism and Protein Synthesis 1st Edition Table of contents:

Section 1: Introduction to Amino Acid Metabolism and Protein Synthesis

1. Overview of Amino Acid Metabolism in the Brain
2. Protein Synthesis Pathways: Molecular and Cellular Perspectives
3. Historical Development of PET Imaging in Metabolic Studies

Section 2: Principles of PET Imaging
4. Basics of Positron Emission Tomography: Techniques and Applications
5. Radiotracers for Amino Acid Metabolism: Design and Characteristics
6. Quantitative Methods in PET Imaging of Protein Synthesis

Section 3: Imaging Amino Acid Metabolism in the Healthy Brain
7. Distribution and Uptake of Key Amino Acids in Neural Tissues
8. Role of Amino Acid Transporters in Brain Function: PET Insights
9. Protein Synthesis in Development and Aging: PET Studies

Section 4: PET Imaging in Neurological Disorders
10. Amino Acid Metabolism in Neurodegenerative Diseases
11. Protein Synthesis Alterations in Stroke and Ischemia
12. Tumor Metabolism: PET Imaging of Gliomas and Brain Tumors

Section 5: PET Imaging in Psychiatric Disorders
13. Amino Acid Metabolism in Depression and Anxiety Disorders
14. Schizophrenia and Altered Protein Synthesis Pathways
15. Autism Spectrum Disorders: Insights from PET Imaging

Section 6: Advances in PET Imaging of Amino Acid Metabolism
16. Development of Novel Radiotracers for Metabolic Studies
17. Integration of PET with Multi-Modal Imaging Techniques (MRI, CT)
18. Computational Approaches for Analyzing PET Data

Section 7: Translational Applications and Future Directions
19. PET Imaging in Drug Development: Targeting Metabolic Pathways
20. Personalized Medicine: Using PET to Tailor Therapeutic Strategies
21. Challenges and Opportunities in PET Imaging of Metabolism

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