Pesticide Toxicology 1st Edition by Eugenia Gallardo, Mário Barroso ISBN 1071619276 9781071619278

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Product details:
ISBN 10: 1071619276
ISBN 13: 9781071619278
Author: Eugenia Gallardo, Mário Barroso

This detailed volume explores practical procedures on the identification and quantification of pesticides in a variety of samples. Chapters guide the reader through methods and protocols for the extraction of pesticides from biological and non-biological samples, pitfalls in dosing techniques and structures identification, and also provide an overview of the problems that these pesticides cause in human populations. As part of the Methods in Pharmacology and Toxicology series, chapters include introductions to their respective topics, lists of reagents and materials, step-by-step guides and reproducible lab protocols, as well as valuable tips on addressing common problems and avoiding known pitfalls.
Authoritative and practical, Pesticide Toxicology is an ideal reference for academia, analysts, toxicologists, environmentalists, and health and industry professionals aiming to understand the associated risks and to limit the use of these substancesand minimize their potential damage to human health and the environment.

Pesticide Toxicology 1st Edition Table of contents:

Chapter 1: Introduction to Pesticides and Their Use

• Definition and Classification of Pesticides
• Historical Background and Development of Pesticides
• Global Usage and Economic Impact of Pesticides
• The Role of Pesticides in Agriculture, Public Health, and Vector Control

Chapter 2: Mechanisms of Pesticide Action

• Mode of Action of Common Pesticides (Insecticides, Herbicides, Fungicides, Rodenticides)
• Biochemical and Physiological Pathways Affected by Pesticides
• Receptor and Enzyme Interactions
• Acute vs. Chronic Toxicity Mechanisms

Chapter 3: Pesticide Absorption, Distribution, Metabolism, and Excretion (ADME)

• Absorption Pathways: Skin, Lungs, and Gastrointestinal Tract
• Distribution and Bioaccumulation in Organs and Tissues
• Biotransformation and Metabolism of Pesticides
• Elimination and Half-Life of Pesticides in the Body

Chapter 4: Toxicokinetics of Pesticides

• Methods for Studying Pesticide Toxicokinetics
• Modeling Pesticide Absorption, Distribution, and Elimination
• Factors Affecting Pesticide Toxicokinetics (Age, Gender, Genetic Variation)
• Case Studies of Specific Pesticides and Their Toxicokinetic Profiles

Chapter 5: Acute Toxicity of Pesticides

• Routes of Exposure and Dose-Response Relationships
• Symptoms and Clinical Signs of Acute Pesticide Poisoning
• Toxicological Endpoints: Lethal Dose (LD50), NOAEL, LOAEL
• Regulatory Guidelines for Acute Toxicity Testing
• Pesticide Poisoning: Epidemiology and Case Reports

Chapter 6: Chronic Toxicity and Long-Term Health Effects

• Chronic Exposure and Its Impact on Human Health
• Carcinogenicity, Mutagenicity, and Teratogenicity of Pesticides
• Neurotoxic and Endocrine Disrupting Effects
• Pesticide-Induced Immune System Alterations
• Long-Term Risk Assessment and Regulatory Approaches

Chapter 7: Environmental Toxicology of Pesticides

• Fate of Pesticides in the Environment: Soil, Water, Air
• Bioaccumulation and Biomagnification in Food Chains
• Ecotoxicology: Effects on Non-Target Organisms (Wildlife, Pollinators, Aquatic Life)
• Pesticide Resistance in Insects, Weeds, and Microorganisms
• Environmental Impact Assessment and Mitigation Strategies

Chapter 8: Pesticide Toxicology in Occupational Settings

• Occupational Exposure to Pesticides: Risk Groups (Farm Workers, Pesticide Applicators)
• Health Effects of Chronic Pesticide Exposure in Workers
• Protective Measures and Personal Protective Equipment (PPE)
• Regulatory Standards and Occupational Safety Guidelines
• Case Studies of Occupational Pesticide Poisoning

Chapter 9: Pesticides and Public Health

• Pesticide Use in Public Health: Malaria, Dengue, and Other Vector-Borne Diseases
• Pesticide Residues in Food and Drinking Water: Risk Assessment
• Pesticides in Household Products: Consumer Exposure and Safety
• Public Health Interventions and Education on Pesticide Safety
• The Role of Government and NGOs in Pesticide Regulation

Chapter 10: Regulatory Framework and Safety Standards

• National and International Pesticide Regulatory Agencies (EPA, WHO, EU)
• Pesticide Registration and Approval Process
• Safety Standards: Maximum Residue Limits (MRLs), Acceptable Daily Intake (ADI)
• Labeling and Communication of Risks to Consumers
• Pesticide Risk Assessment and Management

Chapter 11: Advances in Pesticide Toxicology Research

• Emerging Pesticides and Novel Chemical Classes
• Advances in Biomonitoring and Toxicological Testing
• Molecular Toxicology Approaches in Pesticide Research
• New Tools for Environmental Monitoring and Risk Assessment
• The Role of Genomics and Proteomics in Understanding Pesticide Toxicity

Chapter 12: Pesticide Toxicology and Sustainable Agriculture

• The Role of Integrated Pest Management (IPM) in Reducing Pesticide Use
• Organic Farming and Pesticide-Free Alternatives
• Green Chemistry and Biopesticides: Alternatives to Chemical Pesticides
• The Future of Pesticide Use in Sustainable Agriculture
• Balancing Pesticide Efficacy with Human and Environmental Safety

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