Pathology of Heart Disease in the Fetus Infant and Child Autopsy Surgical and Molecular Pathology 1st edition by Michael Ashworth ISBN 1107116287 978-1107116283

Section 1: Introduction to Pediatric Heart Disease

1. Overview of Pediatric Heart Disease

   • Epidemiology and Causes of Heart Disease in Children

   • Development of the Fetal and Infant Heart

   • Genetic and Environmental Factors in Heart Disease

2. Congenital Heart Disease: General Concepts

   • Classification and Mechanisms

   • Inheritance Patterns and Molecular Basis

   • Risk Factors and Early Diagnosis

Section 2: Pathology of Heart Disease in the Fetus

3. Fetal Cardiac Development and Abnormalities

   • Normal Fetal Circulation and Cardiac Development

   • Common Fetal Heart Malformations

   • In Utero Diagnosis and Imaging of Cardiac Anomalies

4. Fetal Heart Disease: Autopsy Findings

   • Autopsy Techniques for Fetal Heart Disease

   • Chromosomal Abnormalities and Syndromes

   • Specific Pathologies: Hypoplastic Left Heart Syndrome, Transposition of the Great Arteries

Section 3: Pathology of Heart Disease in the Infant

5. Infantile Cardiomyopathies and Myocardial Disease

   • Inherited and Acquired Cardiomyopathies in Infants

   • Heart Failure in the Infant

   • Myocarditis and Other Infectious Diseases

6. Congenital Heart Malformations in Infants

   • Atrial and Ventricular Septal Defects

   • Tetralogy of Fallot, Coarctation of the Aorta

   • Pulmonary Atresia and Tricuspid Atresia

7. Surgical Pathology of Infant Heart Disease

   • Surgical Corrections and Post-Surgical Pathologies

   • Complications After Surgery in Infants

   • Long-Term Outcomes and Surveillance

Section 4: Pathology of Heart Disease in the Child

8. Acquired Heart Disease in Children

   • Rheumatic Heart Disease and Its Pathology

   • Kawasaki Disease and Coronary Artery Pathology

   • Infective Endocarditis in Pediatric Populations

9. Cardiac Tumors in Children

   • Benign and Malignant Cardiac Tumors

   • Diagnostic Features of Cardiac Neoplasms

10. Molecular Pathology in Pediatric Heart Disease

    • Genetic Mutations and Syndromic Heart Disease

    • Molecular Mechanisms in Congenital Heart Defects

    • Advances in Genomic Medicine for Pediatric Heart Disease

Section 5: Diagnostic and Investigative Tools

11. Pathology of Heart Disease in the Context of Imaging

    • Echocardiography, MRI, and CT in Pediatric Heart Disease

    • Role of Molecular Imaging Techniques

    • The Role of Genetic Testing and Biomarkers

12. Autopsy and Post-Mortem Pathology in Pediatric Heart Disease

    • Autopsy Protocols for Pediatric Heart Disease

    • Post-Mortem Evaluation and Diagnosis

    • Forensic Implications in Sudden Cardiac Death

Section 6: Future Directions and Research

13. Advances in the Understanding of Pediatric Cardiac Disease

    • Emerging Research in Fetal and Pediatric Cardiovascular Medicine

    • Stem Cells and Regenerative Medicine

    • Gene Therapy and Personalized Medicine in Pediatric Heart Disease

14. Clinical Trials and New Therapeutic Approaches

    • New Frontiers in Surgical Treatment for Congenital Heart Disease

    • Advances in Pharmacologic Therapy for Pediatric Heart Disease

    • Long-Term Care of Children with Heart Disease