Pathology and Biology of Human Germ Cell Tumors 1st edition by Francisco Nogales, Rafael Jimenez ISBN ‎ B06XG522D7 978-3662537732

Pathology and Biology of Human Germ Cell Tumors 1st edition by Francisco Nogales, Rafael Jimenez – Ebook PDF Instant Download/Delivery.  ‎ B06XG522D7 978-3662537732
Full download Pathology and Biology of Human Germ Cell Tumors 1st edition  after payment

Product details:

ISBN 10:  B06XG522D7
ISBN 13: 978-3662537732
Author:  Francisco Nogales, Rafael Jimenez

This book provides, for the first time, a detailed, up-to-date, holistic approach to the pathology and biology of germ cell tumors. The main focus is the complex histopathology of these tumors, but special considerations are also given to their morphologic variations in relation to age, gender and organ. Critical updates are provided on terminology and classification; the discussion of biology and pathogenesis includes references to many molecular genetic and immunohistochemical findings from recent stem cell research. Individual chapters are devoted to germ cell tumors at different anatomic locations, including not only the ovaries and testes but also the mediastinum and central nervous system, and pediatric tumors. All of the contributing authors are opinion leaders from universities of excellence in Europe and the United States. This monograph will be of wide interest to practitioners and researchers in many fields of medicine, including pathology, gynecology, urology, and pediatrics, as well as stem cell scientists.

Pathology and Biology of Human Germ Cell Tumors 1st Table of contents:

1. Introduction to Germ Cell Tumors

• Overview of germ cell tumors (GCTs): Definition, origin, and classification
• Epidemiology and clinical significance of germ cell tumors
• Pathophysiology of germ cell tumor formation

2. Embryology and Pathogenesis of Germ Cell Tumors

• Germ cell development and migration
• Molecular and genetic mechanisms of tumorigenesis
• Key mutations and genetic markers in germ cell tumors

3. Histopathology of Germ Cell Tumors

• Classification of germ cell tumors (seminomas vs non-seminomatous tumors)
• Histological features of various GCTs (e.g., teratomas, yolk sac tumors, choriocarcinomas, embryonal carcinomas)
• Diagnostic techniques: Histopathological and immunohistochemical markers

4. Genetic and Molecular Biology of Germ Cell Tumors

• Genetic alterations in GCTs (e.g., 12p gain, mutations in tumor suppressor genes)
• Epigenetic changes and their role in tumor progression
• Advances in molecular diagnostics (e.g., genomic sequencing)

5. Clinical Presentation and Diagnosis

• Clinical features of germ cell tumors (e.g., testicular masses, ovarian tumors)
• Diagnostic imaging and laboratory tests
• Tumor markers (e.g., alpha-fetoprotein, beta-hCG) and their use in diagnosis and monitoring

6. Management and Treatment of Germ Cell Tumors

• Surgical management of GCTs (e.g., orchiectomy, resection of ovarian tumors)
• Chemotherapy regimens (e.g., BEP regimen)
• Radiation therapy in the treatment of germ cell tumors

7. Prognosis and Outcome of Germ Cell Tumors

• Factors affecting prognosis (e.g., tumor stage, histology, patient age)
• Long-term survival rates and cure rates for various GCT subtypes
• Follow-up and monitoring after treatment

8. Pediatric and Adult Germ Cell Tumors

• Differences in the presentation and biology of GCTs in children vs adults
• Unique challenges in treating pediatric germ cell tumors
• Fertility preservation in young patients with GCTs

9. Germ Cell Tumors in the Extragonadal Sites

• Pathology of extragonadal germ cell tumors (e.g., mediastinal, retroperitoneal, and central nervous system GCTs)
• Clinical management and challenges with extragonadal GCTs

10. Recent Advances in Germ Cell Tumor Research

• New insights into the molecular pathogenesis of GCTs
• Targeted therapies and immunotherapies in germ cell tumor treatment
• Ongoing clinical trials and future directions in research

11. Case Studies and Clinical Correlations

• Case studies demonstrating clinical-pathological correlations
• Insights into rare and atypical presentations of germ cell tumors
• Lessons from clinical practice and pathology reports

People also search for Pathology and Biology of Human Germ Cell Tumors 1st:

types of germ cell tumors

are germ cell tumors malignant

pathology and genetics

pathology and cell biology columbia

pathology and cell biology