Oral and Intravenous Bisphosphonate Induced Osteonecrosis of the Jaws 2nd Edition by Robert Marx ISBN 9780867159004 0867159006

1 – Description and History of Bisphosphonate-Induced Osteonecrosis of the Jaws

What Is Osteonecrosis of the Jaws?

Early Reports of Bisphosphonate-Induced Osteonecrosis of the Jaws

References

2 – Modes of Action and Pharmacokinetics of the Bisphosphonate Family

Modes of Action

Pharmacokinetics

Why Only in the Jaws?

Accurate Terminology

References

3 – Medical Indications for Bisphosphonates

Role of the Osteoclast in Normal Bone Turnover and Renewal

Osteoclast-Osteoblast Interplay

Intravenous Bisphosphonates and Bone Metastasis

Intravenous Bisphosphonates and Hypercalcemia of Malignancy

Oral Bisphosphonates and Paget Disease

Oral Bisphosphonates and Osteoporosis

Off-Label Use of Bisphosphonates

References

4 – Osteopetrosis: A Genetic Analogue to Bisphosphonate-Induced Osteonecrosis of the Jaws

Clinical Manifestations and Complications of Osteopetrosis

Dental Manifestations and Complications

Treatment of Osteopetrosis

References

5 – Risks, Prevention, and Management of Intravenous Bisphosphonate–Induced Osteonecrosis

Clinical Manifestations

Revised Staging System for BIONJ

Comorbidities in the Development of Intravenous BIONJ

Initiation of Intravenous BIONJ

Recommended Procedures for Prevention and Treatment

Outcome of Treatment Measures

Adjunctive Therapies Not Recommended

Should Intravenous Bisphosphonate Use Be Discontinued?

References

6 – Risks, Prevention, and Management of Oral Bisphosphonate–Induced Osteonecrosis

Risk of Developing Osteonecrosis of the Jaws from an Oral Bisphosphonate

Assessing the Dental Risks of Developing Osteonecrosis of the Jaws

Recommended Procedures for Prevention and Treatment

References

7 – Clinical Pathologic Case Samples

Case 1 – Stage I Intravenous Bisphosphonate–Induced Osteonecrosis

Case 2 – Stage III Intravenous Bisphosphonate–Induced Osteonecrosis

Case 3 – Stage III Intravenous Bisphosphonate–Induced Osteonecrosis

Case 4 – Stage III Intravenous Bisphosphonate–Induced Osteonecrosis

Case 5 – Stage III Intravenous Bisphosphonate–Induced Osteonecrosis

Case 6 – Stage 0 Intravenous Bisphosphonate–Induced Osteonecrosis

Case 7 – Stage I Oral Bisphosphonate–Induced Osteonecrosis

Case 8 – Stage 0 Oral Bisphosphonate–Induced Osteonecrosis

Case 9 – Stage 0 Oral Bisphosphonate–Induced Osteonecrosis

Case 10 – Stage III Oral Bisphosphonate–Induced Osteonecrosis with a Secondary Osteomyelitis and Foreign Bodies

Case 11 – Stage II Oral Bisphosphonate–Induced Osteonecrosis

Case 12 – Stage III Oral Bisphosphonate–Induced Osteonecrosis with a Secondary Osteomyelitis

Case 13 – Stage III Intravenous Bisphosphonate–Induced Osteonecrosis with Extension into the Maxillary Sinus

Case 14 – Stage I Intravenous Bisphosphonate–Induced Osteonecrosis Caused by Once-Yearly Reclast

Case 15 – Stage I Bisphosphonate-Induced Osteonecrosis Caused by Fosamax Followed by Reclast

Case 16 – Stage I Bisphosphonate-Induced Osteonecrosis Caused by Zometa

Glossary

Index