Nutritional Biochemistry 2nd Edition by Tom Brody 0121348369 9780121348366

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ISBN 10: 0121348369

ISBN 13: 9780121348366

Author: Tom Brody 

Nutritional Biochemistry takes a scientific approach to nutrition. It covers not just “whats”–nutritional requirements–but why they are required for human health, by describing their function at the cellular and molecular level. Each case study either leads to a subsequent discovery or enables an understanding of the physiological mechanisms of action of various nutrition-related processes. The text is “picture-oriented” and the commentary is directed towards explaining graphs, figures, and tables.
Nutritional Biochemistry includes a discussion of relevant aspects of physiology, food chemistry, toxicology, pediatrics, and public health. Experimental techniques for nutritional science are emphasized, and primary data is included to help give students a feel for the nutrition literature. This “real-world” approach provides students with a realistic view of the basis for much of our understanding of nutritional biochemistry.

* Integrates biochemistry and nutrition in a case-oriented method
* Emphasizes a hands-on approach to learning – case histories and clinical and research data illustrate all major points
* Places emphasis on metabolism – metabolic pathways, enzymology, nutrient requirements (including RDA values)
* Reveals the benefits of the Mediterranean diet, the biochemistry of exercise, the cell signaling pathways, how nutrition can influence the development of cancer, and the anthropometry and genetics of obesity.

Nutritional Biochemistry 2nd Table of contents:

Chapter 1. CLASSIFICATION OF BIOLOGICAL STRUCTURES

Overview

Basic Chemistry

Macromolecules

Solubility

Cell Structure

Genetic Material

Summary

References

Bibliography

Chapter 2. DIGESTION AND ABSORPTION

Overview

Digestive Tract

Secretion of Digestive Materials

Stimulation of the Digestive System

Molecules Important to Digestion and Absorption

Digestion and Absorption of Proteins

Digestion and Absorption of Lipids

Digestion and Absorption of Carbohydrates

Absorption Physiology

Biochemical Mechanisms

Summary

References

Bibliography

Chapter 3. NUTRIENTS THAT RESIST OR ESCAPE DIGESTION

Overview

Resistance of Proteins to Digestion

Carbohydrates that Escape Digestion

Dietary Fibers

Microorganisms and Digestion

Malabsorption Syndromes

Summary

References

Bibliography

Chapter 4. REGULATION OF ENERGY METABOLISM

Overview

The Brain and Energy Metabolism

Glucagon and Insulin

Different Types of Energy Metabolism

Exercise Nutrition

Creatine Phosphate

Creatinine

Glycogen

Gluconeogenesis

Fructose

Fatty Acids

The Krebs Cycle

Fermentative and Aerobic Energy Metabolism

Starvation

Alcohol

Metabolic Zoning in the Liver

Thiol Esters

Summary

References

Bibliography

Chapter 5. ENERGY REQUIREMENT

Overview

Units of Energy

Calculating the Respiratory Quotient from Chemistry

Electron Transport and ATP Production

Tally of the ATPs Produced

The Respiratory Quotient during Rest and Exercise

Fatty Acid Biosynthesis

Respiratory Quotient Data from Human Studies

Protein Oxidation and the Respiratory Quotient

Calculating Energy Expenditures

Direct Calorimetry

Metabolic Rate

Doubly Labeled Water Technique for Determining Energy Expenditure

Issues in Energy Nutrition

References

Bibliography

Chapter 6. LIPIDS

Overview

Phospholipids

Choline and Ethanolamine

Influence of Dietary Fats on Phospholipids in the Body

Sphingosine-Based Lipids

Covalent Binding of Lipids to Proteins

Cholesterol

Lipoproteins

Studies on the Behavior of Lipoproteins

Cardiovascular Disease

Effects of Diet and Drugs on Atherosclerosis

References

Bibliography

Chapter 7. OBESITY

Overview

Types of Fat

Techniques for Measuring Fat

Signaling Pathways for Regulating Adipocyte Formation

Genetic Factors in Obesity

Summary

References

Bibliography

Chapter 8. PROTEIN

Overview

Milk Protein

Amino Acid Catabolism and Aminotransferases

Biosynthesis of Dispensable Amino Acids

Waste Nitrogen

Regulation of Protein Catabolism

Nutritional Aspects of Protein Catabolism

Protein Quality

Clinical Issues in Protein Nutrition

References

Bibliography

Chapter 9. VITAMINS

Overview

Folate

Vitamin B12

Vitamin K

Biotin

Vitamin B6

Vitamin A

Vitamin D

Vitamin A, Vitamin D, and Thyroid Hormone at the Genome

Niacin

Thiamin

Riboflavin

Pantothenic Acid

Ascorbic Acid (Vitamin C)

Vitamin E

Essential Fatty Acids

References

Bibliography

Chapter 10. INORGANIC NUTRIENTS

Overview

Tables of Inorganic Nutrients

Sodium, Potassium, Chloride, and Water

Iodine

Iron

Calcium and Phosphate

Magnesium

Manganese

Zinc and Copper

Molybdenum, Sulfite, and Sulfate

Selenium and Glutathione

Other Inorganic Nutrients

References

Bibliography

Chapter 11. DIET AND CANCER

Overview

Cancer of the Large Bowel

Genetic Changes that Result in Cancer

RAS and the MAP Kinase Signaling Pathway

Mutations in the RAS Gene and Cancer

Cadherin Protein

Epidemiology of Diet and Colon Cancer

Summary

References

Bibliography

APPENDIX A: NUTRITION METHODOLOGY

References/Bibliography

APPENDIX B: DOT BLOTS, MOLECULAR CLONING, AND DNA SEQUENCING

Assessing Metabolic Regulation by Measuring Changes in Enzyme Activity

Assessing Metabolic Regulation by Measuring Levels of Messenger RNA (Dot Blots)

Using Drug Resistance as a Selection Technique

Restriction Sites and Restriction Enzymes

Phages, Phagemids, and Plasmids Are Used to Acquire DNA for Sequencing

Phages, Plasmids, and Phagemids

Properties of Phage Lambda and of Filamentous Phage

Sequencing of DNA

Summary

References/Bibliography

APPENDIX C: METHODS AND TERMS IN EPIDEMIOLOGY

Algebra Used for Calculating Risk Ratio and Odds Ratio

Acquiring Data on Food and Nutrient Intake

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