Neuroanatomy and Pathology of Sporadic Alzheimer’s Disease 1st edition by Heiko Braak, Kelly Del Tredici ISBN 3319126784 978-3319126784

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Product details:

ISBN 10: 3319126784 
ISBN 13: 978-3319126784
Author: Heiko Braak, Kelly Del Tredici  

This textbook provides a comprehensive overview of Alzheimer’s disease (AD), including its neurobiology, pathology, and clinical presentation. It covers both the sporadic and familial forms of Alzheimer’s disease, with a detailed focus on the neuroanatomy, histopathology, genetic and environmental risk factors, and advances in therapeutics. It also explores the neurodegenerative mechanisms that underlie the disease process, offering insights into the molecular and cellular basis of Alzheimer’s disease.

Neuroanatomy and Pathology of Sporadic Alzheimer’s Disease 1st Table of contents:

• Introduction to Alzheimer’s Disease

  • Overview of Alzheimer’s Disease
  • Historical Background and Discovery

• Epidemiology of Alzheimer’s Disease

  • Prevalence and Incidence
  • Risk Factors (Genetic, Environmental, Lifestyle)

• Neuroanatomy of Alzheimer’s Disease

  • Brain Structures Affected by Alzheimer’s
  • Changes in the Hippocampus and Cortex
  • Regions Involved in Memory and Cognitive Decline

• Molecular and Cellular Pathology

  • Amyloid Plaques: Formation, Accumulation, and Toxicity
  • Tau Tangles: Role in Neurofibrillary Degeneration
  • Synaptic Dysfunction and Loss
  • Neuroinflammation and Glial Activation

• Genetics of Alzheimer’s Disease

  • Familial vs. Sporadic Alzheimer’s Disease
  • Genetic Markers and Risk Genes (e.g., APOE ε4)
  • Gene-environment Interactions

• Pathophysiology of Alzheimer’s Disease

  • Mechanisms of Neurodegeneration
  • Neurovascular Dysfunction
  • The Role of Oxidative Stress and Mitochondrial Dysfunction

• Clinical Features of Alzheimer’s Disease

  • Cognitive Symptoms: Memory Loss, Disorientation, and Language Deficits
  • Behavioral and Psychiatric Symptoms
  • Stages of Alzheimer’s Disease Progression

• Diagnostic Approaches to Alzheimer’s Disease

  • Neuroimaging Techniques (MRI, PET Scans)
  • Biomarkers for Diagnosis
  • Clinical Diagnosis and Differential Diagnosis

• Therapeutic Strategies for Alzheimer’s Disease

  • Current Treatments (Cholinesterase Inhibitors, NMDA Antagonists)
  • Emerging Therapies (Amyloid-targeting, Tau-targeting)
  • Non-pharmacological Interventions

• Future Directions in Alzheimer’s Disease Research

  • Novel Biomarkers and Diagnostic Tools
  • Advances in Drug Development
  • Promising Therapeutic Targets

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