Molecular Pharmacology and Pathology of Strokes 1st edition by Joen Rong Sheu ISBN 3038975419 978-3038975410

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ISBN 10: 3038975419 
ISBN 13: 978-3038975410
Author: Joen Rong Sheu 

Stroke, a progressively non-communicable disease, is the second leading cause of death after coronary heart disease in developed countries. The present treatment options for stroke are adapting lifestyle practices, diabetes treatment, drugs, and the management of other factors, but no cure is yet available, despite new insights into molecular and therapeutic targets. Discoveries related to explicating the molecular pharmacology in cerebrovascular function and thrombosis have led to significant advancements in the current treatment paradigm for patients with stroke. Hence, this Special Issue invited scientific papers and reviews from researchers to provide solid evidence from a molecular point of view to scrutinize the molecular pharmacology and pathology of strokes. Platelet activation plays a major role in cardio and cerebrovascular diseases. Platelets also play a key role in the hemostatic process and are associated with various pathological events, such as arterial thrombosis and atherosclerosis. While the currently used anti-platelet drugs such as aspirin and clopidogrel demonstrate efficacy in many patients, they exert undesirable side effects. Therefore, the development of effective therapeutic strategies for the prevention and treatment of thrombotic diseases is a significant priority. Recently, precious metal drugs have conquered the subject of metal-based drugs, and several investigators have moved their attention to the synthesis of various ruthenium (Ru) and iridium (Ir) complexes due to their prospective therapeutic values. We have published this e-book about the “Molecular Pharmacology and Pathology of Strokes” and anticipate that readers will find this book useful regarding the significant challenges and current advances that are presently being made in stroke research, with the possibility of inspiring the application of novel drug development to enrich the devotion and treatment of patients with cardiovascular diseases.

Molecular Pharmacology and Pathology of Strokes 1st Table of contents:

Section 1: Introduction to Strokes

1. Overview of Stroke
   • Definitions and classifications (ischemic, hemorrhagic, transient ischemic attacks)
   • Pathophysiology of stroke events
   • Risk factors and epidemiology of strokes

Section 2: Molecular Mechanisms of Stroke

2. Molecular Pathology of Stroke
   • Mechanisms of neuronal injury and cell death in stroke
   • Excitotoxicity, oxidative stress, and inflammation in the brain
   • Blood-brain barrier dysfunction during stroke
3. Cell Signaling in Stroke
   • Key molecular pathways involved in stroke-induced injury
   • Role of various signaling molecules such as glutamate, nitric oxide, and inflammatory cytokines
   • Cellular responses to ischemia and reperfusion
4. Molecular Targets for Stroke Therapy
   • Identifying molecular targets for stroke treatment and neuroprotection
   • Key receptors and enzymes involved in stroke pathophysiology

Section 3: Pharmacological Interventions

5. Pharmacology of Stroke Treatment
   • Traditional pharmacological approaches to stroke (antiplatelet, anticoagulant therapy)
   • New pharmacological agents for stroke prevention and treatment
   • Molecular pharmacology of thrombolytic therapies (e.g., tPA)
6. Neuroprotective Strategies
   • Development of drugs targeting neuroprotective pathways
   • Calcium channel blockers, free radical scavengers, and other potential neuroprotectants
   • Challenges and future directions in stroke drug discovery

Section 4: Genetic and Environmental Factors in Stroke

7. Genetic Factors Contributing to Stroke
   • Role of genetic predisposition in stroke susceptibility
   • Molecular genetics of stroke risk factors (e.g., hypertension, diabetes)
8. Environmental and Lifestyle Factors
   • Impact of environmental factors such as diet, exercise, and smoking on stroke risk
   • Molecular mechanisms underlying environmental influences on stroke pathology

Section 5: Clinical Implications and Therapeutic Approaches

9. Stroke Diagnosis and Biomarkers
   • Advances in molecular diagnostics and imaging techniques for stroke
   • Biomarkers of stroke severity, recovery, and prognosis
10. Innovative Therapies and Interventions
    • Experimental therapies for stroke based on molecular pharmacology
    • The role of stem cell therapy and gene therapy in stroke treatment
    • Advances in surgical and endovascular interventions

Section 6: Stroke Rehabilitation and Recovery

11. Rehabilitation and Recovery Mechanisms
    • Molecular mechanisms of stroke recovery and neuroplasticity
    • Role of physical therapy and pharmacological interventions in enhancing recovery
12. Future Prospects in Stroke Treatment
    • Emerging pharmacological and non-pharmacological treatments
    • The future of personalized medicine and tailored therapies for stroke patients

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