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Molecular Pharmacology and Pathology of Strokes 1st Edition by Joen Rong Sheu, Howard Prentice ISBN 9783038975427 303897542X

Name: Molecular Pharmacology and Pathology of Strokes 1st Edition by Joen Rong Sheu, Howard Prentice ISBN 9783038975427 303897542X
SKU: EB-21030
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Authors:Multidisciplinary Digital Publishing Institute (2019) , Author sort:Multidisciplinary Digital Publishing Institute (2019) , Published:Published:Jan 2019

SKU: EB-21030 Category: eBook PDF Tags: Howard Prentice, Joen Rong Sheu, Molecular Pharmacology, Pathology

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Molecular Pharmacology and Pathology of Strokes 1st Edition by Joen Rong Sheu, Howard Prentice – Ebook PDF Instant Download/Delivery. 9783038975427 ,303897542X
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Product details:
ISBN 10: 303897542X
ISBN 13: 9783038975427
Author: Joen Rong Sheu, Howard Prentice

Stroke, a progressively non-communicable disease, is the second leading cause of death after coronary heart disease in developed countries. The present treatment options for stroke are adapting lifestyle practices, diabetes treatment, drugs, and the management of other factors, but no cure is yet available, despite new insights into molecular and therapeutic targets. Discoveries related to explicating the molecular pharmacology in cerebrovascular function and thrombosis have led to significant advancements in the current treatment paradigm for patients with stroke. Hence, this Special Issue invited scientific papers and reviews from researchers to provide solid evidence from a molecular point of view to scrutinize the molecular pharmacology and pathology of strokes. Platelet activation plays a major role in cardio and cerebrovascular diseases. Platelets also play a key role in the hemostatic process and are associated with various pathological events, such as arterial thrombosis and atherosclerosis. While the currently used anti-platelet drugs such as aspirin and clopidogrel demonstrate efficacy in many patients, they exert undesirable side effects. Therefore, the development of effective therapeutic strategies for the prevention and treatment of thrombotic diseases is a significant priority. Recently, precious metal drugs have conquered the subject of metal-based drugs, and several investigators have moved their attention to the synthesis of various ruthenium (Ru) and iridium (Ir) complexes due to their prospective therapeutic values. We have published this e-book about the “Molecular Pharmacology and Pathology of Strokes” and anticipate that readers will find this book useful regarding the significant challenges and current advances that are presently being made in stroke research, with the possibility of inspiring the application of novel drug development to enrich the devotion and treatment of patients with cardiovascular diseases.

Molecular Pharmacology and Pathology of Strokes 1st Edition Table of contents:

Part I: Introduction to Stroke and Its Mechanisms

Overview of Stroke: Types, Etiology, and Epidemiology
- Ischemic vs. Hemorrhagic Stroke
- Risk Factors and Global Epidemiological Trends
- Acute and Chronic Effects of Stroke
- Pathophysiology of Stroke: A Molecular Perspective
Molecular Mechanisms Underlying Stroke Pathogenesis
- Blood-Brain Barrier Disruption
- Glutamate Excitotoxicity and Calcium Influx
- Inflammation and Immune Response in Stroke
- Role of Reactive Oxygen Species (ROS) in Stroke Injury
- Apoptosis and Autophagy in Stroke-Induced Neuronal Damage
The Cellular and Molecular Basis of Stroke Injury
- Ischemic Penumbra and Core Infarct
- Excitotoxicity and Synaptic Dysfunction
- Neurovascular Unit and its Role in Stroke Pathology
- Metabolic Disturbances and Stroke Outcome
- Mechanisms of Blood Flow Recovery

Part II: Pharmacology of Stroke Management

Pharmacokinetics and Pharmacodynamics in Stroke Treatment
- Principles of Drug Absorption, Distribution, Metabolism, and Elimination in Stroke Patients
- Blood-Brain Barrier Penetration and Drug Delivery Strategies
- Drug Dosing and Pharmacological Considerations in Acute Stroke Management
- Therapeutic Drug Window and Titration
Acute Ischemic Stroke: Pharmacological Interventions
- Thrombolytics: Mechanisms and Use of Tissue Plasminogen Activator (tPA)
- Antiplatelet and Anticoagulant Therapy in Acute Stroke
- Neuroprotective Agents: Rationale and Development
- Calcium Channel Blockers and NMDA Receptor Antagonists
- Role of Antioxidants in Stroke Therapy
Hemorrhagic Stroke: Management and Pharmacology
- Management of Intracerebral Hemorrhage (ICH)
- Antihypertensive Therapy in Hemorrhagic Stroke
- Coagulation and Anticoagulation Therapy in ICH
- Emerging Pharmacological Approaches in Hemorrhagic Stroke Treatment
Neuroprotective Agents in Stroke Therapy
- Mechanisms of Neuroprotection: Targets and Pathways
- Role of Free Radicals and Antioxidants
- Agents Modulating Neuroinflammation
- Experimental Drugs and Trials in Stroke Protection
- Advances in Gene Therapy for Stroke Recovery

Part III: Molecular Pathology of Stroke

Cell Death Mechanisms in Stroke
- Necrosis vs. Apoptosis: Cellular Pathways in Stroke
- Autophagy and Mitophagy in Stroke Injury
- Endoplasmic Reticulum Stress and Stroke
- Mitochondrial Dysfunction and Stroke Outcome
- Mechanisms of Axonal Injury and Degeneration
Inflammation and Immune Response in Stroke
- Role of Microglia and Astrocytes in Stroke Pathology
- Cytokine Release and Neuroinflammation in Stroke
- Blood-Brain Barrier Integrity and Immune Cell Infiltration
- Targeting Inflammation as a Therapeutic Strategy
- The Role of the Immune System in Stroke Recovery
Molecular Pathology of Stroke Recovery
- Mechanisms of Tissue Repair and Regeneration
- Plasticity and Neurogenesis After Stroke
- Revascularization and Angiogenesis in Stroke Recovery
- Role of Growth Factors in Stroke Healing
- Impact of Neuroinflammation on Recovery

Part IV: Advances in Stroke Research and Treatment

Emerging Pharmacological Therapies for Stroke
- Stem Cell Therapies for Stroke
- Gene Therapy and Molecular Approaches in Stroke
- Small Molecule Drugs in Stroke Research
- Nanotechnology and Drug Delivery Systems
- Role of Epigenetics in Stroke Prevention and Treatment
Clinical Trials and Future Directions in Stroke Therapy
- Design and Challenges of Stroke Clinical Trials
- Notable Clinical Trials in Stroke Pharmacology
- Advances in Early Stroke Detection and Intervention
- Future Perspectives: Personalized Medicine in Stroke Care

Part V: Special Considerations in Stroke Management

Stroke in Special Populations
- Stroke in Children: Pathophysiology and Treatment Approaches
- Stroke in the Elderly: Challenges and Pharmacological Considerations
- Gender Differences in Stroke Pathology and Treatment
- Ethnic and Genetic Variability in Stroke Outcomes
Stroke Prevention: Molecular and Pharmacological Approaches
- Primary and Secondary Stroke Prevention Strategies
- Antiplatelet and Anticoagulant Therapy in Stroke Prevention
- Role of Lipid Lowering Agents and Antihypertensives
- Lifestyle Factors and Pharmacological Modulation