Molecular Pathology in Clinical Practice 2nd edition by Debra Leonard ISBN 3319196731 ‎ 978-3319196732

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ISBN 10: 3319196731 ‎
ISBN 13: ‎ 978-3319196732
Author: Debra Leonard 

This authoritative textbook offers in-depth coverage of all aspects of molecular pathology practice and embodies the current standard in molecular testing. Since the successful first edition, new sections have been added on pharmacogenetics and genomics, while other sections have been revised and updated to reflect the rapid advances in the field. The result is a superb reference that encompasses molecular biology basics, genetics, inherited cancers, solid tumors, neoplastic hematopathology, infectious diseases, identity testing, HLA typing, laboratory management, genomics and proteomics. Throughout the text, emphasis is placed on the molecular variations being detected, the clinical usefulness of the tests and important clinical and laboratory issues.

The second edition of Molecular Pathology in Clinical Practice will be an invaluable source of information for all practicing molecular pathologists and will also be of utility for other pathologists, clinical colleaguesand trainees.

Molecular Pathology in Clinical Practice 2nd Table of contents:

1. Introduction to Molecular Pathology
   • Overview of molecular pathology and its role in modern medicine
   • Historical development of molecular techniques
   • Importance of molecular pathology in diagnostics
2. Molecular Genetics and Cancer
   • Genetic mutations and their role in cancer
   • Molecular pathways involved in oncogenesis
   • Techniques for detecting genetic mutations (e.g., PCR, sequencing)
3. Molecular Techniques in Diagnostic Pathology
   • Overview of techniques like PCR, FISH, next-generation sequencing (NGS), and microarrays
   • Advantages and limitations of molecular techniques
   • Application of molecular techniques in routine diagnostics
4. Genetic Disorders and Inherited Diseases
   • Molecular pathology in inherited disorders
   • Applications in genetic counseling
   • Detection and diagnosis of inherited mutations
5. Molecular Diagnostics in Infectious Disease
   • Role of molecular techniques in identifying pathogens
   • Advances in PCR and other molecular diagnostic tools for infectious diseases
   • Case studies in infectious disease diagnostics
6. Personalized Medicine and Targeted Therapies
   • Role of molecular pathology in the development of personalized treatments
   • Biomarker discovery for targeted therapies
   • Companion diagnostics and clinical applications
7. Ethical, Legal, and Social Implications of Molecular Pathology
   • Ethical issues surrounding genetic testing
   • Privacy and consent issues in genetic diagnostics
   • Regulatory considerations in molecular pathology
8. Clinical Case Studies
   • Real-world examples of molecular pathology applications in clinical settings
   • Case-based approach to diagnostics and treatment planning
9. Emerging Technologies and Future Directions
   • Advancements in molecular pathology techniques (e.g., CRISPR, liquid biopsy)
   • Future trends in molecular diagnostics
   • Impact of artificial intelligence and data science on molecular pathology
10. Conclusion

• Summary of molecular pathology’s impact on clinical practice
• Ongoing challenges and opportunities for the field

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