Molecular Mechanisms of Cancer 1st Edition by Georg F Weber ISBN 1402060157 9781402060151

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ISBN 10: 1402060157
ISBN 13: 9781402060151
Author: Georg F Weber

Cancer may constitute the most extensively studied functions constitute a second line of defense that disease entity of our time. Nevertheless, our com- protects against transforming defects in oncogenes prehension of the cellular and molecular pathology or tumor-suppressor genes and are here considered of malignant transformation is incomplete. In view as metasuppressor genes. Advances in the molecular of the diverse clinical presentations of various explanations of growth dysregulation, metastasis malignancies, doubts may be raised as to whether it formation, extension of life span, and loss of ma- is appropriate to refer to cancer as one group of dis- tenance of genomic and epigenetic integrity in ease states. The notion of malignant tumors as a cancer suggest models for their causal connection. pathologic and pathophysiologic class of conditions The mechanisms of growth control, senescence, and begs the question for defining criteria that charac- anchorage dependence are linked on the molecular terize all malignant growths, regardless of their tis- level (Chapter 8). In cells that are not fully differ- sue of origin. Toward this goal, the recognition that tiated, the overactivation of oncogene pathways tumor development is caused by the dysregulation also induces the expression of metastasis genes. of growth-controlling genes (oncogenes and tumor- Telomerase, the enzyme that prevents cell sen- suppressor genes) has

Molecular Mechanisms of Cancer 1st Edition Table of contents:

Part I: Basic Concepts in Cancer Biology

1. Introduction to Cancer
   An overview of cancer, its impact on human health, and the general understanding of its molecular and cellular underpinnings.

2. The Hallmarks of Cancer
   Discussion of the key characteristics that define cancer cells, including uncontrolled proliferation, evasion of apoptosis, and angiogenesis.

3. Genetic and Epigenetic Alterations in Cancer
   Exploring the mutations and genetic changes that drive cancer, along with the role of epigenetic changes in tumorigenesis.

4. Oncogenes and Tumor Suppressor Genes
   The role of oncogenes in promoting cancer and how tumor suppressor genes act to prevent uncontrolled growth.

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Part II: Molecular Pathways in Cancer Development

5. Cell Cycle Dysregulation in Cancer
   An examination of how cancer cells bypass normal cell cycle control mechanisms and the molecular pathways involved in cell cycle regulation.

6. Signal Transduction and Cancer
   Understanding the molecular signaling pathways (e.g., receptor tyrosine kinases, G-protein-coupled receptors) that contribute to cancer cell survival and proliferation.

7. DNA Damage and Repair Mechanisms
   The importance of DNA repair systems in maintaining genomic stability, and how defects in these pathways lead to cancer.

8. Metabolism and Cancer
   How alterations in cellular metabolism (Warburg effect) support the rapid growth of tumors and provide new therapeutic targets.

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Part III: Cancer Invasion and Metastasis

9. The Epithelial-Mesenchymal Transition (EMT)
   Mechanisms that enable cancer cells to detach from their primary site and invade other tissues, leading to metastasis.

10. Angiogenesis and Tumor Growth
    The process by which tumors stimulate the formation of new blood vessels to supply oxygen and nutrients to growing tumors.

11. Tumor Microenvironment and Immunosuppression
    How the tumor microenvironment influences cancer progression, including immune evasion and interactions between tumor cells and stromal cells.

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Part IV: Molecular Mechanisms of Specific Cancer Types

12. Breast Cancer: Molecular Insights
    A detailed look at the molecular mechanisms specific to breast cancer, including the role of estrogen receptors and HER2 amplification.

13. Lung Cancer: Genetic and Molecular Drivers
    Understanding the molecular alterations in lung cancer, including mutations in the EGFR gene and the role of tobacco carcinogens.

14. Colorectal Cancer: Pathways and Mutations
    Exploring the genetic and molecular pathways that lead to colorectal cancer, focusing on the APC gene and the Wnt signaling pathway.

15. Leukemia and Lymphoma: Molecular Mechanisms
    The molecular basis of hematological cancers, including the role of chromosomal translocations and tyrosine kinase activity in leukemia.

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Part V: Cancer Therapy and Treatment Strategies

16. Targeted Therapy in Cancer
    An overview of the strategies that target specific molecules or pathways involved in cancer, such as small molecule inhibitors and monoclonal antibodies.

17. Immunotherapy and Cancer
    The role of the immune system in cancer treatment, including checkpoint inhibitors, CAR-T cell therapy, and cancer vaccines.

18. Chemotherapy and Radiation Therapy
    Mechanisms of action of traditional cancer treatments, their molecular targets, and the challenges of resistance.

19. Personalized Medicine and Cancer
    How genomic profiling is transforming cancer treatment by allowing therapies to be tailored to the genetic makeup of an individual’s tumor.

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Part VI: Future Directions in Cancer Research

20. Cancer Stem Cells and Therapy Resistance
    The concept of cancer stem cells and their role in therapy resistance, metastasis, and recurrence.

21. Emerging Technologies in Cancer Research
    Exploration of cutting-edge technologies such as CRISPR, single-cell RNA sequencing, and advanced imaging techniques in cancer research.

22. Precision Oncology: The Future of Cancer Treatment
    How advancements in genomics, bioinformatics, and molecular profiling will shape the future of cancer diagnosis and treatment.

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