Chapter 1: Cells and Genomes
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The Universal Features of Cells on Earth
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The Diversity of Genomes and the Tree of Life
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Genetic Information in Eukaryotes
Chapter 2: Cell Chemistry and Bioenergetics
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The Chemical Components of a Cell
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Catalysis and the Use of Energy by Cells
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How Cells Obtain Energy from Food
Chapter 3: Proteins
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The Shape and Structure of Proteins
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Protein Function
Chapter 4: DNA, Chromosomes, and Genomes
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The Structure and Function of DNA
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Chromosomal DNA and its Packaging in the Chromatin Fiber
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Chromatin Structure and Function
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The Global Structure of Chromosomes
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How Genomes Evolve
Chapter 5: DNA Replication, Repair, and Recombination
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The Maintenance of DNA Sequences
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DNA Replication Mechanisms
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The Initiation and Completion of DNA Replication in Chromosomes
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DNA Repair
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Homologous Recombination
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Transposition and Conservative Site-Specific Recombination
Chapter 6: How Cells Read the Genome: From DNA to Protein
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From DNA to RNA
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From RNA to Protein
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The RNA World and the Origins of Life
Chapter 7: Control of Gene Expression
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An Overview of Gene Control
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Control of Transcription by Sequence-Specific DNA-Binding Proteins
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Transcription Regulators as Gene Switches
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Molecular Genetic Mechanisms that Create and Maintain Specialized Cell Types
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Mechanisms that Reinforce Cell Memory in Plants and Animals
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Post-Transcriptional Controls
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Regulation of Gene Expression by Noncoding RNAs
Chapter 8: Analyzing Cells, Molecules, and Systems
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Isolating Cells and Growing Them in Culture
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Purifying Proteins
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Analyzing Proteins
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Analyzing and Manipulating DNA
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Studying Gene Expression and Function
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Mathematical Analysis of Cell Functions
Chapter 9: Visualizing Cells
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Looking at Cells in the Light Microscope
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Looking at Cells and Molecules in the Electron Microscope
Chapter 10: Membrane Structure
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The Lipid Bilayer
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Membrane Proteins
Chapter 11: Membrane Transport of Small Molecules and the Electrical Properties of Membranes
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Principles of Membrane Transport
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Transporters and Active Membrane Transport
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Channels and the Electrical Properties of Membranes
Chapter 12: Intracellular Compartments and Protein Sorting
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The Compartmentalization of Cells
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The Transport of Molecules Between the Nucleus and the Cytosol
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The Transport of Proteins into Mitochondria and Chloroplasts
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Peroxisomes
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The Endoplasmic Reticulum
Chapter 13: Intracellular Membrane Traffic
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Molecular Mechanisms of Membrane Transport and the Maintenance of Compartmental Diversity
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Transport from the ER through the Golgi Apparatus
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Transport from the Trans Golgi Network to Lysosomes
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Transport into the Cell from the Plasma Membrane: Endocytosis
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Transport from the Trans Golgi Network to the Cell Exterior: Exocytosis
Chapter 14: Energy Conversion: Mitochondria and Chloroplasts
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The Mitochondrion
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The Proton Pumps of the Electron Transport Chain
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ATP Production in Mitochondria
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Chloroplasts and Photosynthesis
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The Genetic Systems of Mitochondria and Chloroplasts
Chapter 15: Cell Signaling
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Principles of Cell Signaling
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Signaling through G-Protein-Coupled Receptors
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Signaling through Enzyme-Coupled Receptors
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Alternative Signaling Routes in Gene Regulation
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Signaling in Plants
Chapter 16: The Cytoskeleton
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Function and Origin of the Cytoskeleton
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Actin and Actin-Binding Proteins
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Myosin and Actin
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Microtubules
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Intermediate Filaments and Septins
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Cell Polarization and Migration
Chapter 17: The Cell Cycle
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Overview of the Cell Cycle
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The Cell-Cycle Control System
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S Phase
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Mitosis
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Cytokinesis
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Meiosis
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Control of Cell Division and Cell Growth
Chapter 18: Cell Death
Chapter 19: Cell Junctions and the Extracellular Matrix
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Cell–Cell Junctions
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The Extracellular Matrix of Animals
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Cell–Matrix Junctions
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The Plant Cell Wall
Chapter 20: Cancer
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Cancer as a Microevolutionary Process
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Cancer-Critical Genes: How They Are Found and What They Do
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Cancer Prevention and Treatment: Present and Future
