Methods for Novel Psychoactive Substance Analysis 1st Edition by Marta Concheiro, Karl Scheidweiler ISBN 1071626078 9781071626078

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Product details:
ISBN 10: 1071626078
ISBN 13: 9781071626078
Author: Marta Concheiro, Karl Scheidweiler

This collection provides detailed information on current advances in analytical methods and strategies employed for monitoring and discovering a wide range of novel psychoactive substances (NPS) in clinical and forensic laboratories. The main classes of NPS in terms of prevalence include synthetic cannabinoids, synthetic cathinones, synthetic opioids, and designer or synthetic benzodiazepines, and this book explores selecting the appropriate sample matrix and analytical testing approaches for laboratories faced with NPS drug testing, such as in blood, urine, saliva, and hair. Written for the Methods in Pharmacology and Toxicology series, chapters in this volume feature the kind of detailed implementation advice from the experts that leads to successful results in the lab.

 

Authoritative and practical, Methods for Novel Psychoactive Substance Analysis serves as an ideal guide for forensic and clinical toxicologists, pharmacologists and chemists inacademic and research settings, as well as for private laboratories seeking to increase our ability to test for these substances.

Methods for Novel Psychoactive Substance Analysis 1st Edition Table of contents:

Chapter 1: Introduction to Novel Psychoactive Substances (NPS)

• Definition and Classification of NPS
• History and Emergence of NPS in the Global Market
• NPS Categories: Stimulants, Hallucinogens, Opioids, and Others
• Challenges in the Detection and Regulation of NPS

Chapter 2: Analytical Approaches to NPS Detection

• Overview of Analytical Techniques in Forensic Toxicology
• Screening vs. Confirmatory Methods in NPS Analysis
• Importance of Sensitivity, Specificity, and Selectivity
• Challenges in NPS Detection Due to Novel Structures

Chapter 3: Sample Collection and Preparation for NPS Analysis

• Biological Matrices: Blood, Urine, Hair, Saliva, and Sweat
• Sample Handling and Storage Considerations
• Pre-Analytical Sample Preparation: Extraction and Cleanup Techniques
• Quality Control and Standardization in Sample Collection

Chapter 4: Chromatographic Techniques for NPS Analysis

• Gas Chromatography (GC) and Gas Chromatography-Mass Spectrometry (GC-MS)
• High-Performance Liquid Chromatography (HPLC)
• Ultra-High-Performance Liquid Chromatography (UHPLC)
• Comprehensive Two-Dimensional Gas Chromatography (GC×GC)
• Method Development, Validation, and Optimization in Chromatographic Analysis

Chapter 5: Mass Spectrometry in NPS Identification

• Principles of Mass Spectrometry for NPS Detection
• Types of Mass Spectrometers: Quadrupole, Time-of-Flight (TOF), and Orbitrap
• Tandem Mass Spectrometry (MS/MS) for Structural Elucidation
• Data Interpretation and Software Tools for Mass Spectrometry
• Case Studies: Identification of Specific NPS Using MS

Chapter 6: Immunoassay Techniques in NPS Detection

• Enzyme-Linked Immunosorbent Assay (ELISA)
• Lateral Flow Immunoassays (LFIA) for Rapid Screening
• Radioimmunoassays (RIA) and Their Limitations in NPS Detection
• Cross-Reactivity Issues and the Need for Confirmatory Analysis
• Innovations in Immunoassays for NPS

Chapter 7: Spectroscopic Techniques for NPS Analysis

• Infrared Spectroscopy (IR) and Raman Spectroscopy
• Nuclear Magnetic Resonance (NMR) Spectroscopy
• Fourier Transform Infrared (FTIR) Spectroscopy
• Applications of Spectroscopy in NPS Screening and Quantification
• Complementary Approaches for Confirmatory Analysis

Chapter 8: Advancements in NPS Screening and Detection

• Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) for NPS
• High-Resolution Mass Spectrometry (HRMS) for Accurate Mass Measurement
• Targeted vs. Non-Targeted Screening for NPS
• The Role of Databases and Chemoinformatics in Identifying New Compounds
• Recent Technological Innovations in NPS Detection

Chapter 9: NPS in Forensic Toxicology: Legal and Regulatory Implications

• The Legal Status of NPS in Different Jurisdictions
• The Role of Forensic Toxicologists in NPS Detection
• Implications of NPS in Drug-Facilitated Crimes and Overdose Cases
• International Efforts to Control and Regulate NPS Use
• Forensic Case Studies: Challenges and Successes in NPS Identification

Chapter 10: Toxicology and Pharmacology of Novel Psychoactive Substances

• Mechanisms of Action of Common NPS
• Toxicological Effects and Risks Associated with NPS Use
• Pharmacokinetics of NPS: Absorption, Distribution, Metabolism, and Excretion
• NPS-Induced Toxicity: Acute, Chronic, and Long-Term Effects
• Case Studies on NPS Poisoning and Overdose

Chapter 11: Emerging Trends and Future Directions in NPS Analysis

• The Role of Artificial Intelligence and Machine Learning in NPS Detection
• Next-Generation Sequencing and Its Potential Applications
• Portable and Field-Based Analytical Methods for NPS Detection
• The Future of NPS Detection in Clinical and Forensic Settings
• Addressing the Challenges of NPS Analogues and Designer Drugs

Chapter 12: Case Studies in NPS Detection and Analysis

• Real-World Case Studies: NPS-Related Overdoses and Toxicology Reports
• Analytical Challenges in Identifying Novel NPS
• Strategies for Overcoming Analytical Difficulties
• International Collaboration in NPS Monitoring and Control
• Lessons Learned and Best Practices for NPS Detection in Forensic Toxicology

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