Medical Pharmacology and Therapeutics 6th Edition by Derek Waller, Anthony Sampson, Andrew Hitchings 0702081590 9780702081590

Medical Pharmacology and Therapeutics 6th Edition by Derek Waller, Anthony Sampson, Andrew Hitchings – Ebook PDF Instant Download/Delivery. 0702081590, 9780702081590

Full download Medical Pharmacology and Therapeutics 6th Edition after payment

Product details:

ISBN 10: 0702081590

ISBN 13: 9780702081590

Author: Derek G. Waller;Anthony Sampson;Andrew Hitchings

 

Medical Pharmacology & Therapeutics provides all the information medical and healthcare students need throughout their degree programme and beyond, including for professional qualifications such as the PSA.

This all-round textbook covers basic pharmacology through to drug prescribing in clinical contexts, covering the pathogenic mechanisms of disease; drug actions, side effects, and the therapeutic principles of drug use. It takes a helpful systems-based approach that orders information according to body systems and disease areas, rather than by drug class.

Now in its sixth edition, the book has been fully updated to include latest scientific understanding of drug action and administration and current best practice in prescribing medications, informed by the latest national guidelines.

Medical Pharmacology and Therapeutics 6th Table of contents:

Section 1 General Principles

Chapter 1 Principles of Pharmacology and Mechanisms of Drug Action

Abstract

Chapter Outline

STUDYING PHARMACOLOGY

RECEPTORS AND RECEPTOR-MEDIATED MECHANISMS

PROPERTIES OF DRUG ACTION

TOLERANCE TO DRUG EFFECTS

GENETIC VARIATION IN DRUG RESPONSES

SUMMARY

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Chapter 2 Pharmacokinetics

Abstract

Chapter Outline

THE BIOLOGICAL BASIS OF CLINICAL PHARMACOKINETICS

ABSORPTION

DISTRIBUTION

ELIMINATION

THE MATHEMATICAL BASIS OF CLINICAL PHARMACOKINETICS

PHARMACOKINETICS OF BIOLOGICAL DRUGS

GENETIC VARIATION AND PHARMACOKINETICS

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Chapter 3 Drug Discovery, Safety and Efficacy

Abstract

Chapter Outline

DRUG DISCOVERY

DRUG APPROVAL

ESTABLISHING SAFETY AND EFFICACY

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Chapter 4 Neurotransmission and the Peripheral Autonomic Nervous System

Abstract

Chapter Outline

THE CENTRAL AND PERIPHERAL NERVOUS SYSTEMS

PRINCIPLES OF NEUROTRANSMISSION

THE PARASYMPATHETIC NERVOUS SYSTEM AND CHOLINERGIC TRANSMISSION

OTHER TRANSMITTERS IN THE PERIPHERAL NERVOUS SYSTEM

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Section 2 The Cardiovascular System

Chapter 5 Ischaemic Heart Disease

Abstract

Chapter Outline

MYOCARDIAL PERFUSION

CLINICAL MANIFESTATIONS OF MYOCARDIAL ISCHAEMIA

DRUGS FOR TREATING ANGINA

MANAGEMENT OF STABLE ANGINA

MANAGEMENT OF ACUTE CORONARY SYNDROMES

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Chapter 6 Systemic and Pulmonary Hypertension

Abstract

Chapter Outline

SYSTEMIC HYPERTENSION

ANTIHYPERTENSIVE DRUGS

PULMONARY ARTERIAL HYPERTENSION

SELF-ASSESSMENT

CASE-BASED QUESTION

ANSWERS

FURTHER READING

Chapter 7 Heart Failure and Shock

Abstract

Chapter Outline

MAINTENANCE OF CARDIAC OUTPUT

PATHOPHYSIOLOGY OF HEART FAILURE

SHOCK

INOTROPIC AND SYMPATHOMIMETIC DRUGS FOR THE TREATMENT OF HEART FAILURE AND SHOCK

MANAGEMENT OF HEART FAILURE

MANAGEMENT OF SHOCK

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Chapter 8 Cardiac Arrhythmias

Abstract

Chapter Outline

BASIC CARDIAC ELECTROPHYSIOLOGY

MECHANISMS OF TACHYARRHYTHMOGENESIS

MECHANISMS OF ACTION AND CLASSIFICATION OF ANTIARRHYTHMIC DRUGS

DRUG TREATMENT OF ARRHYTHMIAS

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Chapter 9 Cerebrovascular Disease and Dementia

Chapter Outline

STROKE

SUBARACHNOID HAEMORRHAGE

DEMENTIA

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Chapter 10 Peripheral Artery Disease

Abstract

Chapter Outline

ATHEROMATOUS PERIPHERAL ARTERY DISEASE

ACUTE AND CRITICAL LIMB ISCHAEMIA

RAYNAUD’S PHENOMENON

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Chapter 11 Haemostasis

Abstract

Chapter Outline

PLATELETS AND PLATELET AGGREGATION

BLOOD COAGULATION AND THE COAGULATION CASCADE

ANTIPLATELET DRUGS

CLINICAL USES OF ANTIPLATELET DRUGS

ANTICOAGULANT DRUGS

CLINICAL USES OF ANTICOAGULANTS

THE FIBRINOLYTIC SYSTEM

CLINICAL USES OF ANTIFIBRINOLYTIC AND HAEMOSTATIC AGENTS

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Section 3 The Respiratory System

Chapter 12 Asthma and Chronic Obstructive Pulmonary Disease

Abstract

Chapter Outline

ASTHMA

CHRONIC OBSTRUCTIVE PULMONARY DISEASE

DRUGS FOR ASTHMA AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE

MANAGEMENT OF ASTHMA

MANAGEMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Chapter 13 Respiratory Disorders: Cough, Respiratory Stimulants, Cystic Fibrosis, Idiopathic Pulmonary Fibrosis and Neonatal Respiratory Distress Syndrome

Abstract

Chapter Outline

COUGH

RESPIRATORY STIMULANTS (ANALEPTIC DRUGS)

CYSTIC FIBROSIS

IDIOPATHIC PULMONARY FIBROSIS

NEONATAL RESPIRATORY DISTRESS SYNDROME

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Section 4 The Renal System

Chapter 14 Diuretics

Abstract

Chapter Outline

FUNCTIONS OF THE KIDNEY

DIURETIC DRUGS

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Chapter 15 Disorders of Micturition

Abstract

Chapter Outline

PATHOPHYSIOLOGY OF MICTURITION

OVERACTIVE BLADDER AND URGE URINARY INCONTINENCE

HYPOTONIC BLADDER

URETHRAL SPHINCTER INCOMPETENCE

LOWER URINARY TRACT SYMPTOMS IN MEN AND BENIGN PROSTATE ENLARGEMENT

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Chapter 16 Erectile Dysfunction

Abstract

Chapter Outline

PHYSIOLOGY OF ERECTION

DRUGS FOR ERECTILE DYSFUNCTION

MANAGEMENT OF ERECTILE DYSFUNCTION

PREMATURE EJACULATION

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Section 5 The Nervous System

Chapter 17 General Anaesthetics

Abstract

Chapter Outline

MECHANISMS OF ACTION OF GENERAL ANAESTHETICS

DRUGS USED IN ANAESTHESIA

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Chapter 18 Local Anaesthetics

Abstract

Chapter Outline

PHARMACOLOGY

TECHNIQUES OF ADMINISTRATION

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Chapter 19 Opioid Analgesics and the Management of Pain

Abstract

Chapter Outline

PAIN AND PAIN PERCEPTION

ANALGESIC DRUGS

PAIN MANAGEMENT

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Chapter 20 Anxiety, Obsessive-Compulsive Disorder and Insomnia

Abstract

Chapter Outline

ANXIETY DISORDERS

OBSESSIVE-COMPULSIVE DISORDER

INSOMNIA

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Chapter 21 Schizophrenia and Bipolar Disorder

Abstract

Chapter Outline

SCHIZOPHRENIA

ANTIPSYCHOTIC DRUGS

MANIA AND BIPOLAR DISORDER

MOOD-STABILISING DRUGS FOR BIPOLAR DISORDER

MANAGEMENT OF BIPOLAR DISORDER

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Chapter 22 Depression, Attention Deficit Hyperactivity Disorder and Narcolepsy

Abstract

Chapter Outline

DEPRESSION

SELF-ASSESSMENT

ANSWERS

Chapter 23 Seizures and Epilepsy

Abstract

Chapter Outline

PATHOLOGICAL BASIS OF SEIZURES AND EPILEPSY

MANAGEMENT OF EPILEPSY

SELF-ASSESSMENT

ANSWERS

Chapter 24 Extrapyramidal Movement Disorders and Spasticity

Abstract

Chapter Outline

THE BASAL GANGLIA AND CONTROL OF MOTOR FUNCTION

PARKINSON’S DISEASE AND RELATED SYNDROMES

DRUGS FOR PARKINSON’S DISEASE

MANAGEMENT OF PARKINSON’S DISEASE AND RELATED SYNDROMES

OTHER INVOLUNTARY MOVEMENT DISORDERS (DYSKINESIAS)

MANAGEMENT OF DYSKINESIAS AND DYSTONIAS

SPASTICITY

MANAGEMENT OF SPASTICITY

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Chapter 25 Other Neurological Disorders: Multiple Sclerosis, Motor Neuron Disease and Guillain–Barré Syndrome

Abstract

Chapter Outline

MULTIPLE SCLEROSIS

MOTOR NEURON DISEASE

GUILLAIN–BARRÉ SYNDROME

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Chapter 26 Migraine and Other Headaches

Abstract

Chapter Outline

MIGRAINE

PATHOGENESIS OF MIGRAINE

DRUGS FOR MIGRAINE

MANAGEMENT OF MIGRAINE AND OTHER HEADACHES

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Section 6 The Musculoskeletal System

Chapter 27 The Neuromuscular Junction and Neuromuscular Blockade

Abstract

Chapter Outline

NEUROMUSCULAR TRANSMISSION

DRUGS ACTING AT THE NEUROMUSCULAR JUNCTION

INDICATIONS FOR NEUROMUSCULAR-BLOCKING DRUGS

ANTAGONISING NEUROMUSCULAR BLOCK

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Chapter 28 Myasthenia Gravis

Abstract

Chapter Outline

ACETYLCHOLINESTERASE (AChE) INHIBITORS

MANAGEMENT OF MYASTHENIA GRAVIS

LAMBERT–EATON MYASTHENIC SYNDROME

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Chapter 29 Nonsteroidal Antiinflammatory Drugs

Abstract

Chapter Outline

THE ROLE OF CYCLOOXYGENASE ENZYMES IN THE ACTIONS OF NONSTEROIDAL ANTIINFLAMMATORY DRUGS

NONSTEROIDAL ANTIINFLAMMATORY DRUGS (NSAIDs)

INDICATIONS FOR USING NONSTEROIDAL ANTIINFLAMMATORY DRUGS

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Chapter 30 Rheumatoid Arthritis, Other Inflammatory Arthritides and Osteoarthritis

Abstract

Chapter Outline

RHEUMATOID ARTHRITIS

OTHER TYPES OF INFLAMMATORY ARTHRITIS: THE SPONDYLOARTHROPATHIES

DRUGS FOR TREATMENT OF INFLAMMATORY ARTHRITIS

MANAGEMENT OF RHEUMATOID ARTHRITIS

MANAGEMENT OF SPONDYLOARTHROPATHIES

OSTEOARTHRITIS

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Chapter 31 Hyperuricaemia, Gout and Pseudogout

Abstract

Chapter Outline

THE PATHOPHYSIOLOGY OF GOUT

DRUGS FOR THE TREATMENT OF GOUT AND PREVENTION OF HYPERURICAEMIA

TREATMENT OF GOUT

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Section 7 The Gastrointestinal System

Chapter 32 Nausea and Vomiting

Abstract

Chapter Outline

NAUSEA AND VOMITING

VERTIGO

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Chapter 33 Dyspepsia, Peptic Ulcer Disease and Gastrooesophageal Reflux Disease

Abstract

Chapter Outline

THE SPECTRUM OF DISEASE

CONTROL OF GASTRIC ACID SECRETION

DRUGS FOR TREATING DYSPEPSIA, PEPTIC ULCER AND GASTROOESOPHAGEAL REFLUX DISEASE

MANAGEMENT OF DYSPEPSIA, PEPTIC ULCER AND GASTROOESOPHAGEAL REFLUX DISEASE

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Chapter 34 Inflammatory Bowel Disease

Abstract

Chapter Outline

INFLAMMATORY BOWEL DISEASE

DRUGS FOR INFLAMMATORY BOWEL DISEASE

MANAGEMENT OF INFLAMMATORY BOWEL DISEASE

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Chapter 35 Constipation, Diarrhoea and Irritable Bowel Syndrome

Abstract

Chapter Outline

CONSTIPATION

DIARRHOEA

IRRITABLE BOWEL SYNDROME

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Chapter 36 Liver Disease

Abstract

Chapter Outline

ACUTE LIVER FAILURE

CHRONIC LIVER DISEASE AND LIVER CIRRHOSIS

AUTOIMMUNE HEPATITIS

PRIMARY BILIARY CHOLANGITIS

CHRONIC VIRAL HEPATITIS

COMPLICATIONS OF DECOMPENSATED CIRRHOSIS

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Chapter 37 Obesity

Abstract

Chapter Outline

PATHOGENESIS OF OBESITY

DRUGS FOR TREATMENT OF OBESITY

MANAGEMENT OF OBESITY

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Section 8 The Immune System

Chapter 38 The Immune Response and Immunosuppressant Drugs

Abstract

Chapter Outline

BIOLOGICAL BASIS OF THE IMMUNE RESPONSE

IMMUNOSUPPRESSANT DRUGS

IMMUNOSUPPRESSION IN INFLAMMATORY AND AUTOIMMUNE DISEASE

IMMUNOSUPPRESSION IN ORGAN TRANSPLANTATION

LONG-TERM EFFECTS OF IMMUNOSUPPRESSION

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Chapter 39 Antihistamines and Allergic Disease

Abstract

Chapter Outline

ATOPY, ALLERGIC DISORDERS AND ANAPHYLAXIS

HISTAMINE AS AN AUTACOID IN HOST DEFENCE

HISTAMINE H1 RECEPTOR ANTAGONISTS (ANTIHISTAMINES)

MECHANISMS OF ACTION AND EFFECTS

MANAGEMENT OF ALLERGIC DISORDERS

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Section 9 The Endocrine System and Metabolism

Chapter 40 Diabetes Mellitus

Abstract

Chapter Outline

CONTROL OF BLOOD GLUCOSE

DIABETES MELLITUS

INSULIN AND INSULIN ANALOGUES FOR TREATMENT OF DIABETES MELLITUS

OTHER PARENTERAL GLUCOSE-LOWERING DRUGS

ORAL GLUCOSE-LOWERING DRUGS

DRUGS TO INCREASE PLASMA GLUCOSE LEVELS

MANAGEMENT OF TYPE 1 DIABETES MELLITUS

MANAGEMENT OF TYPE 2 DIABETES MELLITUS

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Chapter 41 The Thyroid and Control of Metabolic Rate

Abstract

Chapter Outline

THYROID FUNCTION

THYROTOXICOSIS

HYPOTHYROIDISM

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Chapter 42 Calcium Metabolism and Metabolic Bone Disease

Abstract

Chapter Outline

PHYSIOLOGY OF BONE TURNOVER

HYPERCALCAEMIA

HYPOCALCAEMIA

METABOLIC BONE DISEASE

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Chapter 43 Pituitary and Hypothalamic Hormones

Abstract

Chapter Outline

ANTERIOR PITUITARY AND RELATED HYPOTHALAMIC HORMONES

POSTERIOR PITUITARY HORMONES

HYPOPITUITARISM

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Chapter 44 Corticosteroids (Glucocorticoids and Mineralocorticoids)

Abstract

Chapter Outline

CORTICOSTEROID HORMONES

GLUCOCORTICOIDS

MINERALOCORTICOIDS

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Chapter 45 Female Reproduction

Abstract

Chapter Outline

PHYSIOLOGY OF THE MENSTRUAL CYCLE

PHYSIOLOGY OF PREGNANCY

STEROIDAL CONTRACEPTIVES

THE MENOPAUSE

PREGNANCY AND LABOUR

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Chapter 46 Androgens, Antiandrogens and Anabolic Steroids

Abstract

Chapter Outline

ANDROGENS AND ANABOLIC STEROIDS

ANABOLIC STEROIDS

ANTIANDROGENS

5α-REDUCTASE INHIBITORS

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Chapter 47 Anaemia and Haematopoietic Colony-Stimulating Factors

Abstract

Chapter Outline

ANAEMIA

NEUTROPENIA

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Chapter 48 Lipid Disorders

Abstract

Chapter Outline

LIPIDS AND LIPOPROTEINS

FORMATION OF ATHEROMA

DRUGS FOR HYPERLIPIDAEMIAS

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Section 10 The Skin and Eyes

Chapter 49 Skin Disorders

Abstract

Chapter Outline

VEHICLES FOR TOPICAL SKIN APPLICATIONS

ATOPIC AND CONTACT DERMATITIS

PSORIASIS

ACNE VULGARIS

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Chapter 50 The Eye

Abstract

Chapter Outline

TOPICAL APPLICATION OF DRUGS TO THE EYE

MYDRIATIC AND CYCLOPLEGIC DRUGS

GLAUCOMA

OTHER DRUGS ADMINISTERED TOPICALLY TO THE EYE

DRY EYE SYNDROME

AGE-RELATED MACULAR DEGENERATION

DIABETIC RETINOPATHY

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Section 11 Antimicrobial Therapy

Chapter 51 Drugs for Infections

Abstract

Chapter Outline

BACTERIAL INFECTIONS

FUNGAL INFECTIONS

VIRAL INFECTIONS

PROTOZOAL INFECTIONS

HELMINTHIC INFECTIONS

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Section 12 Cancer

Chapter 52 Drugs for Cancer

Abstract

Chapter Outline

THE BIOLOGY OF CANCER

CYTOTOXIC ANTICANCER DRUGS

MECHANISMS OF ACTION

SPECIFIC CYTOTOXIC ANTICANCER DRUGS

TARGETED ANTICANCER DRUGS

CLINICAL USES OF ANTICANCER DRUGS

ANTICANCER DRUG THERAPY FOR SPECIFIC MALIGNANCIES

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Section 13 General Features: Toxicity and Prescribing

Chapter 53 Drug Toxicity and Overdose

Abstract

Chapter Outline

DRUG TOXICITY AND ADVERSE EFFECTS

SELF-POISONING AND DRUG OVERDOSE

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Chapter 54 Substance Abuse and Dependence

Abstract

Chapter Outline

THE BIOLOGICAL BASIS OF DEPENDENCE

DRUGS OF ABUSE

SELF-ASSESSMENT

ANSWERS

FURTHER READING

Chapter 55 Prescribing, Adherence and Information About Medicines

Abstract

Chapter Outline

DUTIES OF THE PRESCRIBER

GENERIC PRESCRIBING

DOSAGE

ADHERENCE, CONCORDANCE AND COMPLIANCE

INFORMING PEOPLE ABOUT THEIR MEDICINES

RATIONAL PRESCRIBING

THE PRESCRIBING SAFETY ASSESSMENT (PSA)

FURTHER READING

Chapter 56 Drug Therapy in Special Situations

Abstract

Chapter Outline

PRESCRIBING IN PREGNANCY

DRUGS AND BREASTFEEDING

PRESCRIBING FOR CHILDREN

PRESCRIBING FOR OLDER PEOPLE

PRESCRIBING IN RENAL FAILURE

PRESCRIBING IN LIVER DISEASE

PRESCRIBING IN PALLIATIVE CARE

DRUG INTERACTIONS

SELF-ASSESSMENT

ANSWERS

FURTHER READING

People also search for Medical Pharmacology and Therapeutics 6th: 

medical pharmacology and therapeutics sixth edition

medical pharmacology and therapeutics pdf free download

medical pharmacology notes

medical pharmacology and physiology mizzou