Introduction to Basics of Pharmacology and Toxicology Volume 3 Experimental Pharmacology 1st Edition by Mageshwaran Lakshmanan, Deepak Gopal Shewade, Gerard Marshall Raj ISBN 9811953457 9789811953453

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Product details:
ISBN 10: 9811953457
ISBN 13: 9789811953453
Author: Mageshwaran Lakshmanan, Deepak Gopal Shewade, Gerard Marshall Raj

This volume is designed to impart the fundamental concepts in experimental pharmacology, research methodology and biostatistics. Through this book, the readers will learn about different methods involved in drug discovery, experimental animals and their care, equipments and the various bioassays used in experimental pharmacology. This book contains special sections on various drug screening methods involved in the evaluation of different body systems. Certain sections provide the healthcare professionals with the knowledge necessary to interpret clinical research articles, design clinical studies, and learn essential concepts in biostatistics in an expedient and concise manner. Basic principles and applications of simple analytical methods employed in drug analysis are well written under one section.

It focuses on the basic and advanced laboratory techniques and also on computer simulated data, written extensively under the Biostatistics section. The methods used for drug analysis have been described in adequate detail with cross-references for further studies and comprehension. Overall, the book is designed systematically with four broad sections with extensive subdivisions for easy tracking, interpretation, and understanding.

Introduction to Basics of Pharmacology and Toxicology Volume 3 Experimental Pharmacology 1st Edition Table of contents:

Chapter 1: Introduction to Experimental Pharmacology

• Definition and Scope of Experimental Pharmacology
• Historical Development and Key Milestones
• Ethical Considerations in Experimental Studies
• Types of Experimental Models in Pharmacology

Chapter 2: Pharmacokinetics in Experimental Studies

• Absorption, Distribution, Metabolism, and Excretion (ADME)
• In-vitro and In-vivo Models for Studying Pharmacokinetics
• Dose-Response Relationship
• Pharmacokinetic Parameters and Their Determination

Chapter 3: Preclinical Drug Development

• Stages of Drug Development: Discovery to Preclinical Trials
• Animal Models in Preclinical Studies
• Safety Pharmacology and Toxicology
• Regulatory Requirements for Preclinical Studies

Chapter 4: Techniques in Experimental Pharmacology

• In-vivo and In-vitro Experimental Techniques
• Organ Perfusion and Isolated Organ Models
• Whole Animal Models in Pharmacological Research
• Cell Culture and Molecular Pharmacology Techniques

Chapter 5: Experimental Approaches to Drug Efficacy

• Assessing Drug Efficacy Using Animal Models
• Methods for Evaluating Drug Effects (Behavioral, Biochemical, and Physiological Endpoints)
• The Role of Placebo and Control Groups in Experimental Studies
• Statistical Methods in Pharmacological Research

Chapter 6: Toxicological Testing and Mechanisms of Toxicity

• Types of Toxicity: Acute, Chronic, Carcinogenic, and Teratogenic
• Experimental Models for Toxicological Studies
• Mechanisms of Drug Toxicity: Cellular and Molecular Basis
• Safety Testing and Toxicity Prediction Methods

Chapter 7: Drug Interactions and Pharmacodynamic Studies

• Types of Drug Interactions: Pharmacokinetic and Pharmacodynamic
• Experimental Methods for Assessing Drug Interactions
• Synergistic and Antagonistic Drug Interactions
• Mechanisms of Drug Interaction at the Molecular Level

Chapter 8: Experimental Toxicology: Case Studies

• Real-life Examples of Experimental Toxicology Studies
• Case Studies in Drug-Induced Organ Toxicity
• Lessons Learned from Animal Studies in Toxicology
• Translating Experimental Findings to Human Toxicology

Chapter 9: Advances in Experimental Pharmacology

• Recent Technological Advances in Experimental Pharmacology
• Role of Genomics and Proteomics in Pharmacological Research
• The Impact of Artificial Intelligence in Drug Discovery and Toxicology
• Future Directions in Experimental Pharmacology and Toxicology

Chapter 10: Regulatory and Ethical Issues in Experimental Pharmacology

• Ethical Guidelines for Animal Research
• Regulatory Bodies: ICH, FDA, EMA, and Their Role in Drug Approval
• Ethical Considerations in Human Clinical Trials
• The 3Rs: Replacement, Reduction, and Refinement in Animal Testing

Chapter 11: Clinical Translational Pharmacology

• Bridging the Gap Between Experimental Studies and Clinical Application
• From Preclinical Trials to Clinical Trials
• Translational Research and Its Challenges
• Personalized Medicine and Its Role in Drug Development

Chapter 12: Future Trends and Challenges in Experimental Pharmacology

• Challenges in Reproducibility and Relevance of Experimental Models
• Emerging Approaches: Organ-on-a-Chip and Humanized Animal Models
• The Role of Big Data and Computational Modeling in Pharmacology
• Future Perspectives in Pharmacological and Toxicological Research

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