Inorganic Biochemistry of Iron Metabolism From Molecular Mechanisms to Clinical Consequences 4th Edition by Robert Crichton 1118925610 9781118925614

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ISBN 10: 1118925610

ISBN 13: 9781118925614

Author: Robert Crichton

Bioinorganic chemists with an interest in iron metabolism, health professionals with an interest in diseases of iron metabolism, and pharmacologists in the pharmaceutical industry interested in developing novel iron-binding drugs

Researchers and students in biochemistry, molecular biology, microbiology, cell biology, nutrition and the medical sciences. 

Inorganic Biochemistry of Iron Metabolism From Molecular Mechanisms to Clinical Consequences 4th Table of contents:

1 Solution Chemistry of Iron

1.1 Iron Chemistry

1.2 Interactions of Iron with Dioxygen and Chemistry of Oxygen Free Radicals

1.3 Hydrolysis of Iron Salts

1.4 Formation and Characterisation of Ferrihydrite

1.5 Ageing of Amorphous Ferrihydrite to more Crystalline Products

1.6 Biomineralisation

1.7 Magnetite Biomineralisation by Magnetotactic Bacteria

References

2 The Essential Role of Iron in Biology

2.1 Introduction: Iron an Essential Element in Biology

2.2 Physical Techniques for the Study of Iron in Biological Systems

2.3 Classes of Iron Proteins

2.4 Haemoproteins

2.5 Iron–Sulphur Proteins

2.6 Non-haem, Non-Fe–S Proteins

2.7 The Dark Side of Iron: ROS, RNS and NTBI

References

3 Microbial Iron Uptake

3.1 Introduction

3.2 Iron Uptake from Siderophores

3.3 Fe2+ transport Systems

3.4 Iron Release from Siderophores in the Cytoplasm

3.5 Intracellular Iron Metabolism

3.6 Control of Gene Expression by Iron

References

4 Iron Acquisition by Pathogens

4.1 Introduction

4.2 Host Defence Mechanisms, Nutritional Immunity

4.3 Pathogenicity and PAIs

4.4 Pathogen-specific Iron Uptake Systems

4.5 Role of Fur and Fur Homologues in Virulence

4.6 Role of Pathogen ECF Sigma Factors

4.7 Fungal Pathogens

References

5 Iron Uptake by Plants and Fungi

5.1 Iron Uptake by Plants

5.2 Iron Metabolism and Homeostasis in Plants

5.3 Iron Uptake, Metabolism and Homeostasis in Fungi

References

6 Cellular Iron Uptake and Export in Mammals

6.1 The Transferrins

6.2 Cellular Iron Uptake

6.3 Cellular Iron Export

References

7 Mammalian Iron Metabolism and Dietary Iron Absorption

7.1 An Overview of Mammalian Iron Metabolism

7.2 Mammalian Iron Absorption

7.3 Molecular Mechanisms of Mucosal Iron Absorption

References

8 Intracellular Iron Utilisation

8.1 Intracellular Iron Pools

8.2 Mitochondrial Iron Metabolism

8.3 Haem Oxygenase

References

9 Iron Storage Proteins

9.1 Introduction

9.2 The Ferritin Superfamily and Haemosiderins

9.3 Iron Uptake and Release from Ferritin

9.4 Biotechnological Applications of Ferritins

References

10 Cellular and Systemic Iron Homeostasis

10.1 Cellular Iron Homeostasis

10.2 Systemic Iron Homeostasis

10.3 Integration of iron homeostatic systems

References

11 Iron Deficiency, Iron Overload and Therapy

11.1 Iron-deficiency Anaemia (IDA)

11.2 Hereditary Iron Overload

11.3 Acquired Iron Overload

References

12 Iron and Immunity

12.1 Introduction

12.2 The key role of macrophages

12.3 Effect of Iron Status on Phagocytic Cell Function

12.4 Effect of Phagocytic Cell Function on Iron Metabolism

12.5 Effector Molecules of the Innate Immune System

12.6 Adaptive immunity

12.7 Immune Function and other Factors

12.8 Concluding remarks

References

13 Iron and Oxidative Stress

13.1 Oxidative stress

References

14 Interactions between Iron and other Metals

14.1 Introduction

14.2 Iron Interactions with Essential Metals

14.3 Iron Interactions with Toxic Metals

References

15 Iron Homeostasis and Neurodegeneration

15.1 Introduction

15.2 Brain Iron

15.3 Iron and Neurodegeneration

15.4 Neurodegeneration with Brain Iron Accumulation

15.5 Other Monogenic Neurodegenerative Diseases

15.6 Neurodegeneration Involving Multiple Genes

15.7 Intracerebral Haemorrhage

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