Infections of the Central Nervous System: Pathology and Genetics 1st edition by Fabrice Chretien, Kum Thong Wong, Leroy Sharer, Katy Keohane, Francoise Gray ISBN 1119467764 978-1119467762

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ISBN 10: 1119467764 
ISBN 13: 4 978-1119467762
Author: Fabrice Chretien, Kum Thong Wong, Leroy Sharer, Katy Keohane, Francoise Gray

Highly commended at the British Medical Association (BMA) Awards 2019, this new volume from the International Society of Neuropathology series addresses infections of the nervous system, written by expert editors. An expansive and inclusive contents list including rare disorders presented in easily referable chapters, containing; definitions, microbiological characteristics, epidemiology, clinical features, lab tests, pathology, genetics and treatment. 

Infections of the Central Nervous System: Pathology and Genetics 1st Table of contents:

Part I: Introduction to CNS Infections

1. Overview of Central Nervous System Infections
   • Importance of CNS Infections in Clinical Neurology
   • Pathophysiology of CNS Infections
   • Host Immune Response to CNS Pathogens
2. General Pathology of CNS Infections
   • Inflammatory Responses in the CNS
   • Mechanisms of Pathogen Entry into the CNS
   • Histopathological Features of CNS Infections
3. Genetic Factors in CNS Infections
   • Genetic Susceptibility to CNS Pathogens
   • Role of Host Genetics in Disease Progression
   • Influence of Genetic Variations on Immune Response

Part II: Bacterial Infections of the CNS

4. Meningitis
   • Bacterial Meningitis: Etiology, Pathogenesis, and Clinical Features
   • Histopathology of Meningitis
   • Genetic Factors Influencing Susceptibility and Outcome
5. Brain Abscesses
   • Pathogenesis and Microbiological Spectrum of Brain Abscesses
   • Diagnostic Imaging and Histopathology
   • Genetic Predispositions and Risk Factors
6. Tuberculous Meningitis
   • Pathophysiology and Diagnosis of Tuberculous Meningitis
   • Histopathological Findings and Immune Response
   • Genetic Markers in Susceptibility and Prognosis
7. Neuroinvasive Bacterial Infections
   • Bacterial Infections Causing Encephalitis
   • Streptococcus pneumoniae, Listeria monocytogenes, and Others
   • Histological and Genetic Insights into Neuroinvasion

Part III: Viral Infections of the CNS

8. Viral Meningitis
   • Epidemiology, Diagnosis, and Pathology of Viral Meningitis
   • Specific Viruses Involved: Enteroviruses, Herpesviruses, and Others
   • Genetic Variability and Immune Response in Viral Meningitis
9. Herpes Simplex Virus Encephalitis
   • Pathogenesis and Clinical Features of HSV Encephalitis
   • Histopathological Findings in HSV Infection
   • Host Genetic Factors in HSV Infection and Outcome
10. Human Immunodeficiency Virus (HIV) and CNS Infections
    • HIV-Related Neurological Disorders: HIV Encephalopathy and Meningitis
    • Pathophysiology and Pathology of HIV CNS Involvement
    • Genetic Factors in HIV-Related CNS Disease
11. Rabies Virus and CNS Infections
    • Pathophysiology of Rabies Virus Infection
    • Histopathological Findings and Diagnostic Challenges
    • Genetic Factors in Rabies Virus Susceptibility and Response

Part IV: Fungal and Parasitic Infections of the CNS

12. Fungal Infections of the CNS
    • Common Fungal Pathogens: Cryptococcus, Aspergillus, and Candida
    • Pathology and Pathogenesis of Fungal Meningitis and Encephalitis
    • Genetic Susceptibility and Host Immune Response
13. Parasitic Infections of the CNS
    • Toxoplasmosis, Neurocysticercosis, and Malaria
    • Pathology and Mechanisms of Parasitic CNS Invasion
    • Genetic Factors Influencing Host Defense Against Parasitic Infections

Part V: Other CNS Infections and Emerging Pathogens

14. Prion Diseases
    • Pathogenesis of Prion Infections: Creutzfeldt-Jakob Disease and Others
    • Histopathological Features of Prion Disease
    • Genetic Predispositions to Prion Diseases
15. Neurotropic Bacterial Infections
    • Emerging and Rare Pathogens in CNS Infections: Bartonella, Treponema pallidum
    • Pathological Features and Genetic Insights into Emerging Infections
16. Emerging Viral Infections in the CNS
    • Zika Virus, West Nile Virus, and Other Emerging Viruses
    • Pathology and Genetic Aspects of New CNS Pathogens
    • Role of Genetics in Disease Susceptibility and Outcome

Part VI: Diagnostics and Management of CNS Infections

17. Diagnostic Approaches in CNS Infections
    • Laboratory Diagnosis: CSF Analysis, PCR, and Serology
    • Imaging Techniques in CNS Infections: MRI, CT, and PET
    • Genetic Testing in the Diagnosis and Prognosis of CNS Infections
18. Treatment of CNS Infections
    • Antimicrobial Therapy: Antibiotics, Antivirals, Antifungals
    • Immunotherapies and Adjunctive Treatments
    • The Role of Genetic Information in Personalized Treatment
19. Management of Complications in CNS Infections
    • Sequelae of CNS Infections: Cognitive Impairment, Seizures, and Neurological Deficits
    • Rehabilitation Strategies for CNS Infection Survivors
    • Genetic Markers of Recovery and Long-Term Outcomes

Part VII: Prevention and Future Directions

20. Prevention of CNS Infections
    • Vaccination Strategies for CNS Infections (e.g., Meningitis, Polio)
    • Public Health Approaches to Preventing CNS Infections
    • Genetic Counseling for Families at Risk of Inherited CNS Infections
21. Future Directions in CNS Infection Research
    • Emerging Genetic Technologies in the Study of CNS Infections
    • Advances in Vaccine Development for CNS Pathogens
    • Novel Therapeutic Approaches Based on Genetic Insights

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