In Vivo Neuropharmacology and Neurophysiology 1st Edition by Athineos Philippu ISBN 1493964887 9781493964888

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ISBN 10:       1493964887
ISBN 13: 978-1493964888
Author:         Athineos Philippu

This volume presents classical approaches to in vivo neuropharmacology and neurophysiology, such as c-fos, electrochemistry, microdialysis microstimulation, and push-up superfusion. It also explores exciting new methods for behavioral analysis, and techniques based on optogenetics and non-invasive magnetic resonance imaging. The chapters of this book cover topics such as principles of stereotaxy, pharmaco-based fMRI and neurophysiology in humans and non-human primates, electrical nerve stimulation and central microstimulation, involvement of neurotransmitters in mnemonic processes, the impact of cannabinoids on motor activity, as well as the involvement of nitric oxide in neurotoxicity produced by psychostimulant drugs. Each chapter also discusses difficulties, tips, tricks, and precautions to take. Neuromethods series style chapters include the kind of detail and key advice from the specialists needed to get successful results in your own laboratory.

Cutting-edge andpractical, In Vivo Neuropharmacology and Neurophysiology is a valuable resource for experienced and less experienced investigators of brain function and brain disorders.

In Vivo Neuropharmacology and Neurophysiology 1st Table of contents:

• Stereotaxy in Small Animals: Principles of stereotaxic techniques used for targeting specific brain regions in small animal models, a critical method in neuroscience research for investigating brain function.

• EEG Indices of Cortical Network Formation: The use of electroencephalography (EEG) to measure the formation of cortical networks and how these networks correlate with subjective experiences and behaviors in animals.

• Pharmaco-Based fMRI and Neurophysiology in Non-Human Primates: Combining pharmacology with functional magnetic resonance imaging (fMRI) and neurophysiological measurements to study brain activity in non-human primates.

• Optogenetic Manipulations and Neuronal Network Oscillations: The combination of optogenetics and electrophysiological techniques in behaving mice to manipulate and study neuronal network oscillations, shedding light on brain functioning.

• 3D-Video-Based Behavioral Analysis in Rodents: Use of 3D-video technology to analyze rodent behavior in vivo for neuropharmacology and neurophysiology studies, offering detailed insights into animal behavior under various conditions.

• Operant Self-Administration of Chocolate in Rats: A study of addiction-like behavior in rats, focusing on their self-administration of chocolate, which models addictive behaviors in neuroscience research.

• Electrical Nerve Stimulation and Central Microstimulation: The use of electrical stimulation of nerves and the central nervous system to understand brain function and behavior.

• In Vivo Biosensors for Brain Chemistry Monitoring: The development and application of biosensors, particularly based on Prussian Blue, to monitor brain chemistry and neurochemical changes in living animals.

• In Vivo Electrochemistry for Monitoring Extracellular Molecules: Methodological considerations for using electrochemistry to monitor extracellular neurotransmitters and other molecules involved in brain function.

• Push-Pull Superfusion Technique: A technique for studying neurotransmitter involvement in brain function by infusing and extracting fluid from brain tissue, providing insights into neurotransmitter dynamics.

• Push-Pull Superfusion in Mnemonic Processes and Fear Conditioning: Investigating the role of neurotransmitters in memory processes, response to noxious stimuli, and conditioned fear using push-pull superfusion.

• Neurophysiological Approaches in Neuropharmacology: Methods for examining the role of neurotransmitters and neural circuits in pharmacological studies, focusing on drug interactions with brain function.

• Neurotransmitter Involvement in Behavior and Blood Pressure: Research on how neurotransmitters influence behavior and control blood pressure, exploring their role in autonomic functions.

• Functional Mapping of Somatostatin Receptors: In vivo microdialysis studies to understand the distribution and role of somatostatin receptors in the brain.

• Impact of Cannabinoids on Motor Activity and Neurochemistry: A study of how cannabinoids affect motor activity and the neurochemical correlates of these changes in brain function.

• Modeling Schizophrenia: Developmental Models: Focusing on developmental models of schizophrenia to understand the disorder’s pathophysiology and its neurobiological underpinnings.

• Immunohistochemical Analysis of Fos Protein: Exploring brain regions related to central nervous system disorders and drug actions using Fos protein expression as a marker for neuronal activity.

• Involvement of Nitric Oxide in Neurotoxicity: Investigating how nitric oxide contributes to neurotoxicity, particularly when induced by psychostimulant drugs.

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