How synthetic drugs work 1st Edition by Imran Kazmi, Sanmoy Karmakar, Md Adil Shaharyar, Muhammad Afzal, Fahad Al Abbasi ISBN 9780323913683 032391368X

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Product details:
ISBN 10: 032391368X
ISBN 13: 9780323913683
Author: Imran Kazmi, Sanmoy Karmakar, Md Adil Shaharyar, Muhammad Afzal, Fahad Al Abbasi

How synthetic drugs work 1st Edition Table of contents:

Part I: Introduction to Synthetic Drugs

1. Overview of Synthetic Drugs

   • Definition and Types of Synthetic Drugs
   • Historical Development of Synthetic Pharmaceuticals
   • Chemical Synthesis vs. Natural Drug Sources
   • Global Trends in Synthetic Drug Use and Abuse

2. The Science of Drug Design

   • The Drug Discovery Process: From Concept to Creation
   • Molecular Targeting and Rational Drug Design
   • Structure-Activity Relationships (SAR)
   • Advanced Techniques in Drug Synthesis

3. Pharmacokinetics and Pharmacodynamics

   • Absorption, Distribution, Metabolism, and Excretion (ADME)
   • Mechanisms of Drug Action at the Molecular Level
   • Therapeutic Window and Dose-Response Relationship
   • Factors Influencing Drug Activity: Genetic, Environmental, and Physiological

Part II: Mechanisms of Action of Synthetic Drugs

4. Receptors and Drug-Receptor Interactions

   • Types of Drug Receptors: Ion Channels, G-Protein Coupled Receptors (GPCRs), Enzyme-Linked Receptors
   • Agonists, Antagonists, and Allosteric Modulators
   • Signal Transduction Pathways
   • Receptor Desensitization and Tolerance

5. Enzyme Inhibition and Activation

   • Enzyme Mechanisms in Drug Action
   • Competitive vs. Non-Competitive Inhibition
   • Allosteric Enzyme Regulation
   • Drug-Related Enzyme Induction and Its Impact

6. Ion Channel Modulation

   • The Role of Ion Channels in Drug Action
   • Voltage-Gated vs. Ligand-Gated Ion Channels
   • Synthetic Drugs as Ion Channel Modulators
   • Clinical Relevance: Antiarrhythmics, Anticonvulsants, and Local Anesthetics

7. Genetic and Epigenetic Modulation by Synthetic Drugs

   • Gene Expression and Drug Action
   • Synthetic Drugs as Epigenetic Modulators
   • Role of Synthetic Drugs in Gene Regulation
   • Implications for Personalized Medicine

8. Synthetic Drugs and Enzyme Systems

   • Cytochrome P450 Enzyme System and Drug Metabolism
   • Drug-Drug Interactions and the Role of Enzymes
   • Therapeutic Implications of Enzyme Modulation
   • Case Studies in Synthetic Drug Metabolism

Part III: Classes of Synthetic Drugs

9. Stimulants and Psychotropic Drugs

   • Mechanisms of Action of CNS Stimulants
   • Synthetic Cathinones, Amphetamines, and Designer Drugs
   • Antidepressants and Antipsychotics: Mechanisms and Effects
   • Modulation of Neurotransmitter Systems

10. Opioids and Analgesics

    • Mechanism of Action of Opioids at the Receptor Level
    • Synthetic Opioids: Fentanyl, Methadone, and Others
    • Analgesic Efficacy and Side Effects
    • The Opioid Crisis: Synthetic Opioids and Public Health

11. Sedatives, Anxiolytics, and Hypnotics

    • Benzodiazepines and Non-Benzodiazepine Sedatives
    • Mechanisms of Action in GABAergic Systems
    • Synthetic Barbiturates and Their Use in Anesthesia
    • Side Effects and Risks of Sedative Drugs

12. Antibiotics and Antimicrobials

    • Mechanism of Action of Synthetic Antibiotics
    • Antibiotic Resistance and Synthetic Drug Development
    • Antivirals and Antifungals: Targeting Pathogen-Specific Mechanisms
    • Emerging Synthetic Antimicrobial Drugs

13. Hormones and Synthetic Hormonal Therapies

    • Mechanisms of Action of Synthetic Hormones
    • Synthetic Steroid Hormones and Their Uses
    • Oral Contraceptives and Hormone Replacement Therapy
    • Targeted Hormonal Treatments in Cancer

Part IV: Toxicity, Side Effects, and Drug Interactions

14. Toxicology of Synthetic Drugs

    • Acute vs. Chronic Toxicity
    • Mechanisms of Drug-Induced Organ Damage
    • Synthetic Drug Toxicity in the Liver, Kidney, and Heart
    • Toxicological Assessment of Synthetic Drugs

15. Side Effects of Synthetic Drugs

    • Common Side Effects and Their Mechanisms
    • Adverse Drug Reactions and Idiosyncratic Responses
    • Role of Genetic Variability in Drug Response
    • Managing and Preventing Side Effects

16. Drug Interactions and Synergy

    • Mechanisms of Drug-Drug Interactions
    • Clinical Relevance of Drug Synergy and Antagonism
    • Polypharmacy and Risks in Drug Combinations
    • Managing Drug Interactions in Clinical Practice

Part V: Applications of Synthetic Drugs in Medicine

17. Synthetic Drugs in Pain Management

    • Mechanisms of Analgesia: Opioids, NSAIDs, and Other Agents
    • Development of Synthetic Analgesics
    • Targeted Drug Delivery Systems in Pain Management
    • Emerging Therapies for Chronic Pain

18. Cancer Chemotherapy: Synthetic Drugs and Cancer Treatment

    • Mechanisms of Action of Chemotherapeutic Agents
    • Synthetic Anticancer Drugs: Mechanisms of DNA Damage and Repair
    • Targeted Therapies and Immunotherapy
    • Challenges in Cancer Drug Resistance

19. Cardiovascular Drugs: Mechanisms and Applications

    • Synthetic Drugs in the Treatment of Hypertension, Arrhythmias, and Heart Failure
    • Beta Blockers, ACE Inhibitors, and Other Cardiovascular Drugs
    • Vasodilators and Antithrombotic Drugs
    • Novel Cardiovascular Synthetic Drugs in Development

Part VI: Future Directions in Synthetic Drug Development

20. Emerging Technologies in Drug Design

    • Artificial Intelligence and Machine Learning in Drug Discovery
    • Nanotechnology and Drug Delivery Systems
    • The Role of Biologics and Biopharmaceuticals
    • Future Trends in Synthetic Drug Development

21. Ethical and Regulatory Considerations

    • Ethical Issues in Synthetic Drug Development and Use
    • Regulatory Agencies and Drug Approval Process
    • The Global Impact of Synthetic Drug Legislation
    • Intellectual Property and Patents in Drug Discovery

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