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Heart Failure Bench to Bedside 2010th Edition by Jose Marin Garcia ISBN 1607611465 9781607611462

Name: Heart Failure Bench to Bedside 2010th Edition by Jose Marin Garcia ISBN 1607611465 9781607611462
SKU: EB-2300
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Authors:JosÃ© MarÃn-GarcÃa , Author sort:MarÃn-GarcÃa, JosÃ© , Ids:9781607611462 , Published:Published:Jun 2010

SKU: EB-2300 Category: eBook PDF Tags: Bedside 2010th, Bench, Heart Failure, Jose Marin Garcia

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ISBN 10: 1607611465
ISBN 13: 978-1607611462
Author: José Marín-García

Heart Failure (HF) is the final and common pathway of all cardiovascular diseases. Heart Failure: Bench to Bedside helps address a significant need to develop new paradigms and to identify novel therapeutic targets for this pervasive disease. An authoritative contribution to the field, this book provides a detailed description of new findings and emerging methodologies, as well as a critical clinical evaluation of the complex HF syndrome and future therapies. Heart Failure: Bench to Bedside includes a primer on gene profiling and bioenergetics of the normal heart and a discussion of the molecular, genetic, biochemical and cellular techniques critical to understanding HF. Further chapters discuss cardiac remodeling, oxidative stress, and alterations in other organs and systems that are often associated with HF. This book thoughtfully evaluates current and forthcoming diagnostic techniques and therapies, pharmaceutical and pharmacogenomic-based individualized medicine, gene and cell-based therapies, and the search for new frontiers. Heart Failure: Bench to Bedside presents a clear view of up-to-date approaches to clinical diagnosis and treatment, as well as offering insightful critiques of original and creative scientific thoughts on post-genomic HF research.

Heart Failure: Bench to Bedside 2010th Table of contents:

1. Clinical, Physiology, and Genetic Changes in Heart Failure

Introduction to Heart Failure
Cardiac Function in Heart Failure: The Role of Calcium Cycling
Gene Profiling of the Failing Heart: Epigenetics

2. Biochemical and Molecular Changes in Heart Failure

Bioenergetics and Metabolic Changes in the Failing Heart

3. The Mitochondrial Organelle and the Heart

The Multidimensional Role of Mitochondria in Heart Failure

4. Experimental Models of Heart Failure

Animal Models of Heart Failure

5. Signaling, Stress, and Cellular Changes in Heart Failure

Signaling Cascades in Heart Failure: From Cardiomyocyte Growth and Survival to Mitochondrial Signaling Pathways
Cyclic Nucleotides Signaling (Second Messengers) and Control of Myocardial Function: Effects of Heart Failure
Calcium Signaling: Receptors, Effectors, and Other Signaling Pathways
Oxidative Stress and Heart Failure
Cardiac Remodeling and Cell Death in Heart Failure

6. Peripheral Changes and Co-morbid Conditions in Heart Failure

Heart Failure and Changes at the Periphery: Vascular, Inflammation, Neurohormonal, and Renal Systems
Comorbidities in Heart Failure

7. Heart Failure in Children

Mechanisms, Clinical Recognition, and Management of Heart Failure in Infants and Children
Mechanical Circulatory Support and Heart Transplantation in Children with Severe Refractory Heart Failure

8. Aging and the Failing Heart

Basic Mechanisms Mediating Cardiomyopathy and Heart Failure in Aging
Heart Failure of Aging: Clinical Considerations

9. Diagnostic Methodology in Heart Failure

Diagnosis of Heart Failure: Evidence-Based Perspective
“Omics” Application in Heart Failure: Novel Diagnostic and Prognostic Markers to Understand Pathophysiology and Find New Therapies

10. Available and Forthcoming Therapies for Heart Failure

Treatment of Chronic Heart Failure
Gene Therapy in Heart Failure: Forthcoming Therapies
Myocardial Cell-Based Regeneration in Heart Failure

11. Looking to the Future

Future Frontiers in Heart Failure

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