Harpers Illustrated Biochemistry 30th Edition by Victor Rodwell, David Bender, Kathleen Botham, Peter Kennelly, Anthony Weil ISBN B00QKUJ9CO 978-0071825344

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ISBN 10: B00QKUJ9CO
ISBN 13: 978-0071825344
Author: Victor Rodwell, David Bender, Kathleen Botham, Peter Kennelly, Anthony Weil

HE BEST REVIEW FOR THE USMLE!

The Thirtieth Edition of Harper’s Illustrated Biochemistry combines outstanding full-colorillustrations with authoritative integrated coverage of biochemical disease and clinical information. Using brevity and numerous medically relevant examples, Harper’s presents a clear, succinct review of the fundamentals of biochemistry that every student must understand in order to succeed in medical school.

All fifty-eight chapters emphasize the medical relevance of biochemistry

• Full-color presentation includes more than 600 illustrations
• Each chapter includes a section on BiomedicalImportance and a summary of the topics covered
• Review questions follow each of the eleven sections
• Case studies in every chapter emphasize the clinical relevance to biochemistry
• NEW coverage of toxic naturally-occurring amino acids; extraterrestrial biomolecules; computer-aided drug design; the role of complement cascade in bacterial and viral infection; secreted mediators of cell-cell signaling between leukocytes; the role of mast cells, basophils, andeosinophils; and the hazard of antioxidants that down-regulate radical signaling for apoptosis and increase risk of cancer

 

Applauded by medical students for its current and engaging style, Harper’s Illustrated Biochemistry is an essential for USMLE review and the single best reference for learning the clinical relevance of any biochemistry topic.

Harpers Illustrated Biochemistry 30th Table of contents:

Part I: Introduction to Biochemistry

1. Biochemistry: An Overview

   • The central role of biochemistry in biology and medicine
   • Key principles of biochemistry: structure, function, and regulation
   • Chemical basis of life

2. Water and the Biochemical Basis of Life

   • Properties of water and its importance in biological systems
   • Hydrogen bonds, ionic interactions, and pH
   • Buffers in biological systems

3. Amino Acids and Proteins

   • Structure and properties of amino acids
   • Peptide bond formation and protein structure (primary, secondary, tertiary, quaternary)
   • Protein folding and function
   • Enzyme catalysis and mechanisms
   • Protein denaturation and diseases related to protein misfolding

Part II: Structure and Function of Biomolecules

4. Enzymes: Structure and Function

   • Enzyme classification and mechanisms
   • Kinetics of enzyme action (Michaelis-Menten, Lineweaver-Burk)
   • Enzyme inhibition and regulation

5. Nucleic Acids: Structure and Function

   • Structure of DNA and RNA
   • DNA replication, transcription, and translation
   • Genetic code and protein synthesis
   • DNA repair and recombination

6. Carbohydrates: Structure and Function

   • Monosaccharides, disaccharides, and polysaccharides
   • Glycosidic bonds and carbohydrate metabolism
   • Role of carbohydrates in energy storage and cell signaling

7. Lipids: Structure and Function

   • Types of lipids: triglycerides, phospholipids, sterols
   • Fatty acid metabolism and regulation
   • Lipid bilayers and membrane structure
   • Cholesterol and its role in the body

8. Biochemical Energetics

   • Thermodynamics in biochemical reactions
   • Free energy and ATP hydrolysis
   • Redox reactions and electron transport

Part III: Metabolism

9. Carbohydrate Metabolism

   • Glycolysis and gluconeogenesis
   • The citric acid cycle (Krebs cycle)
   • Oxidative phosphorylation and ATP production
   • Regulation of blood glucose levels

10. Fatty Acid and Lipid Metabolism

    • Beta-oxidation of fatty acids
    • Lipogenesis and fatty acid synthesis
    • Ketogenesis and the role of ketone bodies
    • Lipid transport and utilization

11. Amino Acid and Protein Metabolism

    • Amino acid catabolism and urea cycle
    • Nitrogen metabolism and excretion
    • Synthesis and degradation of proteins
    • Metabolic disorders related to amino acids

12. Nucleotide Metabolism

    • Purine and pyrimidine metabolism
    • De novo synthesis and salvage pathways
    • Disorders in nucleotide metabolism (e.g., gout)

13. Integration of Metabolism

    • Metabolic regulation and coordination between organs
    • Hormonal control of metabolism (insulin, glucagon, cortisol, etc.)
    • Energy balance and metabolic diseases (diabetes, obesity)

Part IV: Molecular Biology and Biotechnology

14. Molecular Biology Techniques

    • PCR, gel electrophoresis, and DNA sequencing
    • Cloning and recombinant DNA technology
    • Applications in diagnostics and research

15. Genomics and Proteomics

    • Human genome and gene expression
    • Genomic sequencing and its implications
    • Protein structure and function prediction

Part V: Biochemical Basis of Disease

16. Biochemical Basis of Diseases

    • Metabolic diseases (e.g., inborn errors of metabolism)
    • Biochemical pathways in cancer
    • Genetic diseases (e.g., sickle cell anemia, cystic fibrosis)
    • Cardiovascular disease and biochemistry of lipoproteins
    • Disorders of enzyme function and their clinical implications

17. Nutrition and Biochemistry

    • Role of vitamins, minerals, and trace elements in biochemistry
    • Nutrient absorption and metabolism
    • Biochemical consequences of deficiencies or excesses (e.g., scurvy, rickets)

18. Endocrine Regulation

    • Hormones and their biochemical pathways
    • Mechanisms of hormone action (e.g., insulin, thyroid hormones)
    • Disorders of endocrine signaling (e.g., diabetes, thyroid disorders)

Part VI: Clinical Biochemistry

19. Diagnostic Biochemistry

    • Use of biochemical tests in diagnostics (blood tests, liver function, kidney function)
    • Biomarkers of disease
    • Clinical relevance of enzyme activity and genetic testing

20. Pharmacology and Drug Biochemistry

    • Drug metabolism and pharmacokinetics
    • Pharmacodynamics and the molecular basis of drug action
    • Enzyme inhibitors and their therapeutic applications (e.g., statins, ACE inhibitors)

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