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Genomic Applications in Pathology 2nd Edition by George Jabboure Netto, Karen Kaul 3319968297 9783319968292

Name: Genomic Applications in Pathology 2nd Edition by George Jabboure Netto, Karen Kaul 3319968297 9783319968292
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Authors:George Jabboure Netto, Karen L. Kaul , Series:Pathology [292] , Author sort:George Jabboure Netto, Karen L. Kaul , Languages:Languages:eng , Published:Published:Nov 2018 , Publisher:Springer

SKU: EB-21222 Category: eBook PDF Tags: Applications, Genomic, George Jabboure Netto, Karen Kaul

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ISBN 10: 3319968297

ISBN 13: 9783319968292

Author: George Jabboure Netto, Karen L. Kaul

The recent advances in genomics are continuing to reshape our approach to diagnostics, prognostics and therapeutics in oncologic and other disorders. A paradigm shift in pharmacogenomics and in the diagnosis of genetic inherited diseases and infectious diseases is unfolding as the result of implementation of next generation genomic technologies. With rapidly growing knowledge and applications driving this revolution, along with significant technologic and cost changes, genomic approaches are becoming the primary methods in many laboratories and for many diseases. As a result, a plethora of clinical genomic applications have been implemented in diagnostic pathology laboratories, and the applications and demands continue to evolve rapidly. This has created a tremendous need for a comprehensive resource on genomic applications in clinical and anatomic pathology. We believe that our current textbook provides such a resource to practicing molecular pathologists,hematopathologists and other subspecialized pathologists, general pathologists, pathology and other trainees, oncologists, geneticists and a growing spectrum of other clinicians. With periodic updates and a sufficiently rapid time from submission to publication, this textbook will be the resource of choice for many professionals and teaching programs. Its focus on genomics parallels the evolution of these technologies as primary methods in the clinical lab. The rapid evolution of genomics and its applications in medicine necessitates the (frequent) updating of this publication. This text will provide a state-of-the art review of the scientific principles underlying next generation genomic technologies and the required bioinformatics approaches to analyses of the daunting amount of data generated by current and emerging genomic technologies. Implementation roadmaps for various clinical assays such as single gene, gene panels, whole exome and whole genome assays will bediscussed together with issues related to reporting and the pathologist’s role in interpretation and clinical integration of genomic tests results. Genomic applications for site-specific solid tumors and hematologic neoplasms will be detailed. Genomic applications in pharmacogenomics, inherited genetic diseases and infectious diseases will also be discussed. The latest iteration of practice recommendations or guidelines in genomic testing put forth by stakeholder professional organizations such as the College of American Pathology and the Association for Molecular Pathology, will be discussed as well as regulatory issues and laboratory accreditation related to genomic testing. All chapters will be written by experts in their fields and will include the most up to date scientific and clinical information.

Genomic Applications in Pathology 2nd Table of contents:

Part I. Genomic Technologies

1. Practicing Pathology in the Post-genomic Era: Challenges and Opportunities

2. Current Massively Parallel Sequencing Technologies: Platforms and Reporting Considerations

3. Emerging Next-Generation Sequencing Technologies

4. Transcriptome Sequencing (RNA-Seq)

5. miRNA Expression Assays

6. Circulating Tumor Cells: Enrichment and Genomic Applications

7. Circulating Cell-Free DNA for Molecular Diagnostics and Therapeutic Monitoring

Part II. Practice-Related Aspects of Clinical Genomics

8. Genomic Pathology: Training for New Technology

9. Clinical Implementation of Next-Generation Sequencing (NGS) Assays

10. Regulatory and Reimbursement Issues Related to Genomic Testing Services

11. Patents and Proprietary Assays

12. Ethical Issues in Clinical Genetics and Genomics

Part III. Clinical Implementation of Diagnostic Genomics

13. Transitioning Discoveries from Cancer Genomics Research Laboratories into Pathology Practice

14. Bioinformatics Tools in Clinical Genomics

15. Next-Generation Sequencing for Single-Gene Analysis

16. Next-Generation Sequencing for Gene Panels

17. Implementation of Exome Sequencing Assay

18. Implementation of Genome Sequencing Assays

19. Clinical Information Systems in the Era of Personalized Medicine

20. Reporting Clinical Genomic Assay Results and the Role of the Pathologist

Part IV. Genomic Applications in Oncology

21. Genomic Applications in Hematologic Oncology

22. Genomic Applications in Brain Tumors

23. Genomic Applications in Head and Neck Cancers

24. Genomic Applications in Thyroid Cancer

25. Genomic Applications in Salivary Gland Tumors

26. Genomic Applications in Breast Carcinoma

27. Genomic Applications in Pulmonary Malignancies

28. Genomic Applications in Colorectal Carcinomas

29. Genomic Applications in Pancreatic and Gastric Tumors

30. Molecular Pathology of Genitourinary Cancers: Translating the Cancer Genome to the Clinic

31. Genomic Applications in Gynecologic Malignancies

32. Genomic Applications in Ovarian Cancer

33. Genomic Applications in Soft Tissue Sarcomas

34. Genomic Applications in Melanoma

Part V. Genomic Applications in Inherited and Infectious Diseases, Pharmacogenomics, and the Microbiome

35. Genomic Applications in Inherited Genetic Disorders

36. Sequencing Cell-Free DNA in the Maternal Circulation to Screen for Down Syndrome, Other Common Trisomies, and Selected Genetic Disorders

37. Genomic Applications in the Clinical Management of Infectious Diseases

38. Pharmacogenomics: Success and Challenges

39. The Human Microbiome in Health and Disease

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