Genome Stability and Human Diseases 1st Edition by Heinz Peter Nasheuer 9048134706 9789048134700

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ISBN 10: 9048134706

ISBN 13: 9789048134700

Author: Heinz Peter Nasheuer

Since the establishment of the DNA structure researchers have been highly interested in the molecular basis of the inheritance of genes and of genetic disorders. Scientific investigations of the last two decades have shown that, in addition to oncogenic viruses and signalling pathways alterations, genomic instability is important in the development of cancer. This view is supported by the findings that aneuploidy, which results from chromosome instability, is one of the hallmarks of cancer cells. Chromosomal instability also underpins our fundamental principles of understanding tumourigenesis: It thought that cancer arises from the sequential acquisition of genetic alterations in specific genes. In this hypothesis, these rare genetic events represent rate-limiting ‘bottlenecks’ in the clonal evolution of a cancer, and pre-cancerous cells can evolve into neoplastic cells through the acquisition of somatic mutations. This book is written by international leading scientists in the field of genome stability. Chapters are devoted to genome stability and anti-cancer drug targets, histone modifications, chromatin factors, DNA repair, apoptosis and many other key areas of research. The chapters give insights into the newest development of the genome stability and human diseases and bring the current understanding of the mechanisms leading to chromosome instability and their potential for clinical impact to the reader.

Genome Stability and Human Diseases 1st Table of contents:

Coming Full Circle: Cyclin-Dependent Kinases as Anti-cancer Drug Targets

Core and Linker Histone Modifications Involved in the DNA Damage Response

Chromatin Assembly and Signalling the End of DNA Repair Requires Acetylation of Histone H3 on Lysine 56

Structure and Function of Histone H2AX

The Initiation Step of Eukaryotic DNA Replication

Non-coding RNAs: New Players in the Field of Eukaryotic DNA Replication

Function of TopBP1 in Genome Stability

Eukaryotic Single-Stranded DNA Binding Proteins: Central Factors in Genome Stability

DNA Polymerases and Mutagenesis in Human Cancers

DNA Polymerase η, a Key Protein in Translesion Synthesis in Human Cells

The Mitochondrial DNA Polymerase in Health and Disease

Centromeres: Assembling and Propagating Epigenetic Function

Nucleotide Excision Repair in Higher Eukaryotes: Mechanism of Primary Damage Recognition in Global Genome Repair

Nonhomologous DNA End Joining (NHEJ) and Chromosomal Translocations in Humans

Fluorescence-Based Quantification of Pathway-Specific DNA Double-Strand Break Repair Activities: A Powerful Method for the Analysis of Genome Destabilizing Mechanisms

Apoptosis: A Way to Maintain Healthy Individuals

The Use of Transgenic Mice in Cancer and Genome Stability Research

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