Gastric Cancer In The Precision Medicine Era Diagnosis and Therapy 1st edition by Vincenzo Canzonieri, Antonio Giordano ISBN 3030048608 978-3030048600

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ISBN 10: 3030048608 
ISBN 13: 978-3030048600
Author: Vincenzo Canzonieri, Antonio Giordano 

Gastric cancer is one of the most common and potentially lethal gastrointestinal malignancy, but it is now at the forefront of modern oncology due to new discoveries. In recent years, the field of gastric cancer has been transformed by many notable developments in both the diagnostic area and the therapeutic strategies.
The main aim of the text is to propose a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for oncologists, pathologists, surgeons and researchers with an interest in gastric cancer. The first chapters will review the interplay between pathogens and especially H. pylori, inflammation, genomic instability, and tumorigenesis. Secondly, an exhaustive overview of the diagnosis of gastric cancer from a clinical/endoscopic and pathologic perspectives will be illustrated. Two specific chapters will deal with tissue and serum biomarkers with an important role in diagnosis as well as prognostic and predictive markers of response to specific therapy. A central section of the book will focus on treatment options available today for patients. Surgery is the cornerstone of treatment for gastric cancer; however, the prognosis of patients with locally advanced disease is still poor even after curative resection. Therefore, in order to improve the prognosis of patients, especially with advanced stage, a multimodal strategy is advisable and is thoroughly addressed in the appropriate section.
With the advent of next-generation sequencing and new preclinical model technologies, the genomic landscape of gastric cancer has been delineated and molecular characterizations finalized to novel therapeutic targets of each molecular subtype have been identified. These advances are making it feasible to integrate clinical and phenotype-based diagnostic and therapeutic methods and are described in a dedicated section. The text will conclude with chaptersfocusing on the future direction of gastric cancer research in the precision medicine era: an in-depth analysis of non-coding RNAs and their role in gastric cancer, the impact of immunomodulation/immunotherapy and the perspectives of nano-medicine will be finally proposed to the audience. A brief review of the existing literature addressing the above mentioned topics will be present in each chapter.
This text will serve as a useful resource for physicians and researchers dealing with, and interested in, this challenging malignancy. It will provide a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters will be written by experts in their fields and will include the most up to date scientific and clinical information.

Gastric Cancer In The Precision Medicine Era Diagnosis and Therapy 1st Table of contents:

• Introduction to Gastric Cancer
  • Overview of gastric cancer: Epidemiology, risk factors, and clinical challenges.
  • Historical perspectives on gastric cancer diagnosis and treatment.
• Molecular Biology of Gastric Cancer
  • Genetic mutations and alterations in gastric cancer.
  • Understanding gastric cancer at the molecular level (e.g., mutations in the HER2, EGFR, and other genes).
  • Advances in molecular biology influencing treatment strategies.
• Diagnostic Approaches
  • Current diagnostic techniques for gastric cancer (e.g., endoscopy, imaging, biopsy).
  • Molecular diagnostic tools, including genomic sequencing.
  • Role of biomarkers in early detection and diagnosis.
• Precision Medicine and Gastric Cancer
  • The role of precision medicine in tailoring treatment to individual genetic profiles.
  • How personalized medicine is changing the landscape of gastric cancer therapy.
  • Case studies or examples of successful implementation of precision medicine.
• Targeted Therapies in Gastric Cancer
  • Review of targeted therapies such as HER2 inhibitors, VEGF inhibitors, and immune checkpoint inhibitors.
  • Mechanisms of action and clinical efficacy of targeted treatments.
  • Clinical trials and research outcomes in precision therapy.
• Immunotherapy in Gastric Cancer
  • The role of immunotherapy in treating advanced gastric cancer.
  • Checkpoint inhibitors (e.g., PD-1/PD-L1 inhibitors) and their application.
  • Future directions in immunotherapy for gastric cancer.
• Surgical Treatment and Chemotherapy
  • Traditional surgical approaches and their integration with precision therapies.
  • Chemotherapy regimens: Challenges and evolution with precision medicine.
• Challenges and Future Directions
  • Barriers to the widespread use of precision medicine in gastric cancer treatment.
  • Discussion on the need for more biomarkers and better clinical trials.
  • Future research directions in personalized therapy and diagnostics.
• Conclusion
  • Summarization of the potential of precision medicine in revolutionizing gastric cancer care.
  • Reflection on how precision medicine is improving outcomes for patients with gastric cancer.

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