Fundamentals of Toxicologic Pathology 3rd editon by Wanda Haschek,Brad Bolon,Colin Rousseaux,Matthew Wallig ISBN 0128098414 978-0128098417

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ISBN 10: 0128098414
ISBN 13: 978-0128098417
Author: Wanda Haschek,Brad Bolon,Colin Rousseaux,Matthew Wallig 

Fundamentals of Toxicologic Pathology, Third Edition, presents an essential overview of systems toxicologic pathology in a clear-and-concise manner. Toxicologic pathology integrates toxicology and its interdisciplinary components, including biochemistry, pharmacodynamics and risk assessment to pathology and its related disciplines, such as physiology, microbiology, immunology and molecular biology. This wholly revised and updated edition presents the newest information on the topic, and is an essential reference for advanced students, early career researchers, toxicologic pathologists, pharmaceutical scientists, medical pathologists and clinicians, and anyone involved with drug and device development.

The book includes a new section describing the application of toxicologic pathology, such as diagnostic and forensic toxicologic pathology, environmental toxicologic pathology, experimental and industrial toxicologic pathology, and pathology issues in the design of toxicology studies. There are also new chapters on special senses (the eye and ear) and the biochemical and molecular basis of toxicity

Fundamentals of Toxicologic Pathology 3rd Table of contents:

• Introduction to Toxicologic Pathology

  • Definition and scope of toxicologic pathology.
  • Importance of toxicology in pathology.
  • Role of toxicologic pathologists in risk assessment and regulatory science.

• Basic Concepts in Toxicology

  • Overview of toxicology and toxicokinetics.
  • Dose-response relationships.
  • Mechanisms of toxicity and cellular responses.
  • Biotransformation of toxins.

• General Principles of Toxicologic Pathology

  • Principles of studying pathology in toxicology.
  • Methods of toxicologic testing.
  • In vivo versus in vitro studies in toxicology.
  • Models used in toxicology and their relevance to human health.

• Histopathological Techniques in Toxicology

  • Preparation of tissue samples for toxicologic studies.
  • Special stains and techniques used in toxicology.
  • Microscopic examination and evaluation of toxicologic lesions.

• Pathology of Organ Systems in Toxicology

  • Hepatic Toxicity: Liver pathology in toxicologic studies.
  • Renal Toxicity: Kidney pathology and the effects of toxins.
  • Pulmonary Toxicity: Lung pathology and environmental toxicants.
  • Cardiac Toxicity: Effects of toxins on the heart.
  • Nervous System Toxicity: Neurotoxicology and the blood-brain barrier.
  • Gastrointestinal Toxicity: Effects on the GI tract.
  • Hematologic and Immune System Toxicity: Toxic effects on blood cells and immunity.

• Endocrine and Reproductive Toxicology

  • Toxic effects on the endocrine system.
  • Disruption of reproductive health: effects on fertility and development.
  • Toxicology of sexual differentiation and developmental toxicity.

• Carcinogenicity and Genotoxicity

  • Mechanisms of carcinogenesis in toxicology.
  • Genotoxicity testing methods.
  • Pathology of tumors induced by chemical exposure.
  • Regulatory approaches to carcinogenic risk.

• Environmental Toxicology and Occupational Toxicology

  • Toxic effects of environmental pollutants and chemicals.
  • Occupational exposure risks and industrial toxicology.
  • Pathology related to air, water, and soil contamination.

• Regulatory and Safety Assessment in Toxicology

  • Safety evaluation of chemicals and pharmaceuticals.
  • Guidelines for toxicological studies and regulatory requirements.
  • Risk assessment and risk management strategies.

• Case Studies in Toxicologic Pathology

  • Clinical case studies highlighting toxic effects on various organs.
  • Application of toxicologic pathology in drug safety testing.
  • Review of high-profile cases of chemical exposure and their pathological findings.

• Emerging Topics in Toxicologic Pathology

  • New methods in toxicology research (e.g., omics technologies, biomarkers).
  • Environmental impact and the evolving field of ecotoxicology.
  • Advances in understanding the mechanisms of toxicity.

• Conclusion and Future Directions in Toxicologic Pathology

  • Challenges and opportunities in the field of toxicologic pathology.
  • Emerging trends and technologies.
  • The evolving role of toxicologic pathologists in global health and environmental science.

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