Fundamentals of Protein Structure and Function 1st Edition by Engelbert Buxbaum ISBN 0387263527 9780387263526

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Product details:
ISBN 10: 0387263527
ISBN 13: 9780387263526
Author: Engelbert Buxbaum

The textbook is clearly written, and is suitable for advanced students, e.g. during their master and PhD course time. It is very suited also for postdocs and young scientists as a textbook if they change fields in their research. The textbook represents a thorough and detailed description of the topics in each of the chapters. As the book selects very important topics of present fundamental research and relevant in medical biochemistry, it can supplement any of the text books in biochemistry and basic medicine already on the market.

The textbook is clearly written, and is suitable for advanced students, e.g. during their master and PhD course time. It is very suited also for postdocs and young scientists as a textbook if they change fields in their research. The textbook represents a thorough and detailed description of the topics in each of the chapters. As the book selects very important topics of present fundamental research and relevant in medical biochemistry, it can supplement any of the text books in biochemistry and basic medicine already on the market.

Fundamentals of Protein Structure and Function 1st Edition Table of contents:

Chapter 1: Introduction to Protein Chemistry

• The Role of Proteins in Biological Systems
• Historical Overview of Protein Research
• Protein Diversity and Their Functions
• The Central Dogma of Molecular Biology: DNA to Protein

Chapter 2: Basic Principles of Protein Structure

• Levels of Protein Structure: Primary, Secondary, Tertiary, and Quaternary
• Amino Acids: Building Blocks of Proteins
• Peptide Bonds and Protein Sequence
• The Role of Disulfide Bridges in Protein Stability

Chapter 3: Protein Folding and Stability

• The Folding Process: From Linear Chain to Functional Structure
• Thermodynamics of Protein Folding
• Chaperones and Protein Folding Pathways
• Protein Misfolding and Disease: Prions and Amyloidosis

Chapter 4: Protein Structure Determination

• Techniques for Protein Structure Analysis
• X-Ray Crystallography and NMR Spectroscopy
• Cryo-Electron Microscopy (Cryo-EM)
• Computational Approaches in Protein Structure Prediction

Chapter 5: Protein-Protein Interactions

• The Importance of Protein-Protein Interactions in Cellular Function
• Mechanisms of Protein-Protein Binding
• Domains and Motifs in Protein-Protein Recognition
• Experimental Methods to Study Protein-Protein Interactions

Chapter 6: Enzyme Structure and Function

• Enzymes as Biological Catalysts
• Mechanisms of Enzyme Catalysis: Lock and Key vs. Induced Fit
• Kinetics of Enzyme Reactions: Michaelis-Menten Equation
• Allosteric Regulation and Enzyme Inhibition

Chapter 7: Structural Basis of Enzyme Specificity

• Substrate Recognition and Binding
• Active Site Architecture and Catalytic Mechanisms
• Enzyme Co-factors: Metal Ions and Coenzymes
• Enzyme Engineering for Industrial Applications

Chapter 8: Membrane Proteins and Their Functions

• The Role of Membrane Proteins in Cellular Processes
• Types of Membrane Proteins: Integral vs. Peripheral
• Protein Transport Across Membranes
• Techniques for Studying Membrane Proteins

Chapter 9: Structural Biology of Signal Transduction

• Signal Transduction Pathways in Cells
• Receptors and G-Protein Coupled Receptors (GPCRs)
• Tyrosine Kinases and Phosphorylation Cascades
• Structural Insights into Cellular Signaling Mechanisms

Chapter 10: Protein Dynamics and Allostery

• Protein Flexibility and Function
• Allosteric Regulation of Protein Function
• Cooperativity in Hemoglobin and Other Systems
• Molecular Dynamics Simulations in Protein Dynamics

Chapter 11: Post-Translational Modifications of Proteins

• Types of Post-Translational Modifications: Phosphorylation, Glycosylation, Acetylation
• The Role of PTMs in Protein Function and Regulation
• Enzymes Involved in PTM and Their Impact on Cellular Function
• PTMs in Disease Mechanisms and Drug Development

Chapter 12: Protein Evolution and Functional Diversity

• Evolution of Protein Sequences and Structures
• Sequence Homology and Phylogenetic Analysis
• Evolution of Protein Function and Adaptation
• Protein Engineering and Synthetic Biology

Chapter 13: Proteomics and Protein Quantification

• Introduction to Proteomics and Its Applications
• Techniques in Protein Quantification: Mass Spectrometry, Western Blotting
• Protein Microarrays and Functional Genomics
• Challenges and Future Directions in Proteomics

Chapter 14: Diseases Associated with Protein Misfolding and Dysfunction

• Genetic Diseases Due to Protein Mutations (Cystic Fibrosis, Sickle Cell Anemia)
• Neurodegenerative Diseases: Alzheimer’s, Parkinson’s, Huntington’s Disease
• Cancer and Oncogenic Mutations in Protein Function
• Therapeutic Strategies Targeting Protein Misfolding

Chapter 15: Protein Therapeutics and Drug Design

• The Role of Proteins in Drug Development
• Biopharmaceuticals: Monoclonal Antibodies, Enzyme Replacement Therapies
• Designing Protein-Based Drugs: Antibodies and Engineered Proteins
• The Future of Protein Therapeutics and Personalized Medicine

Chapter 16: Future Directions in Protein Research

• Advances in Structural Biology Techniques
• Integration of Systems Biology and Protein Function
• New Horizons in Protein Engineering and Biotechnology
• The Role of Artificial Intelligence in Protein Design

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