Fundamentals of Medicinal Chemistry 1st Edition by Gareth Thomas ISBN 9780470871690 0470871695
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Authors:Gareth Thomas , Series:Biochemistry [3] , Tags:Medical; Chemotherapy; Science; Chemistry; General; 0470843071 , Author sort:Thomas, Gareth , Ids:Google; 9780470843079 , Languages:Languages:eng , Published:Published:Nov 2003 , Publisher:Wiley , Comments:Comments:Provides a concise introduction to the chemistry of therapeutically active compounds, written in a readable and accessible style. The title begins by reviewing the structures and nomenclature of the more common classes of naturally occurring compounds found in biological organisms. An overview of medicinal chemistry is followed by chapters covering the discovery and design of drugs, pharmacokinetics and drug metabolism, The book concludes with a chapter on organic synthesis, followed by a brief look at drug development from the research stage through to marketing the final product. The text assumes little in the way of prior biological knowledge. relevant biology is included through biological topics, examples and the Appendices. Incorporates summary sections, examples, applications and problems Each chapter contains an additional summary section and solutions to the questions are provided at the end of the text Invaluable for undergraduates studying within the chemical, pharmaceutical and life sciences.
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ISBN 10: 0470871695
ISBN 13: 9780470871690
Author: Gareth Thomas
Fundamentals of Medicinal Chemistry 1st Edition Table of contents:
Chapter 1: Introduction to Medicinal Chemistry
- Overview of Medicinal Chemistry and Drug Discovery
- The Role of Medicinal Chemistry in Healthcare
- Drug Design and Development Process
- Structure-Activity Relationships (SAR) and Bioavailability
Chapter 2: Basic Concepts in Pharmacology
- Pharmacokinetics: Absorption, Distribution, Metabolism, and Excretion (ADME)
- Pharmacodynamics: Drug-Receptor Interactions
- Dose-Response Curves and Therapeutic Index
- Drug Action and Mechanism of Action
Chapter 3: Drug Target Identification and Validation
- The Role of Drug Targets in Medicinal Chemistry
- Types of Drug Targets: Receptors, Enzymes, and Ion Channels
- Methods of Target Identification and Validation
- High-Throughput Screening and Virtual Screening in Drug Discovery
Chapter 4: Chemical Principles in Drug Design
- Functional Groups and Their Role in Drug Activity
- The Role of Stereochemistry in Drug Action
- Binding Interactions: Hydrogen Bonding, Van der Waals Forces, and Hydrophobic Interactions
- Molecular Modelling and Computational Drug Design
Chapter 5: Drug Metabolism and Toxicology
- Phase I and Phase II Metabolic Reactions
- Enzyme Inhibition and Induction in Drug Metabolism
- Pharmacogenomics and Personalized Medicine
- Toxicology and Adverse Drug Reactions
Chapter 6: Antibacterial Agents
- Mechanisms of Action of Antibiotics
- Beta-Lactams, Aminoglycosides, and Tetracyclines
- Resistance Mechanisms and Overcoming Resistance
- New Approaches in Antibiotic Drug Design
Chapter 7: Antiviral Agents
- Mechanisms of Action of Antiviral Drugs
- Nucleoside Analogs and Protease Inhibitors
- Antiretroviral Therapy for HIV
- Antiviral Drug Resistance and Strategies to Overcome It
Chapter 8: Anticancer Drugs
- Mechanisms of Action of Anticancer Agents
- Alkylating Agents, Antimetabolites, and Hormonal Therapies
- Targeted Therapy and Monoclonal Antibodies
- Immunotherapy and the Future of Cancer Treatment
Chapter 9: Analgesics and Anti-inflammatory Drugs
- Mechanisms of Pain and Inflammation
- Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
- Opioids and Their Mechanisms of Action
- New Developments in Analgesic Drug Design
Chapter 10: Central Nervous System (CNS) Drugs
- Neurotransmitter Systems and Drug Action
- Antidepressants, Antipsychotics, and Anxiolytics
- Benzodiazepines and Barbiturates
- Emerging Therapeutics in Neurological Disorders
Chapter 11: Cardiovascular Drugs
- Mechanisms of Action in Cardiovascular Disease
- Antihypertensive Drugs: Diuretics, ACE Inhibitors, and Beta Blockers
- Antiarrhythmic Drugs
- Lipid-Lowering Agents: Statins and Beyond
Chapter 12: Endocrine Drugs
- Hormones and Their Role in Drug Therapy
- Antidiabetic Drugs: Insulin and Oral Hypoglycemics
- Thyroid Hormones and Antithyroid Drugs
- Steroid Hormones and Their Applications
Chapter 13: Drug Delivery Systems
- Drug Absorption and Bioavailability
- Controlled Release and Targeted Drug Delivery
- Nanomedicine and Drug Delivery
- Biocompatibility and Safety Considerations in Drug Delivery
Chapter 14: Natural Products in Medicinal Chemistry
- The Role of Natural Products in Drug Discovery
- Plant-Derived Drugs and Their Mechanisms of Action
- Marine-Derived Natural Products
- Biotechnology and Natural Product Synthesis
Chapter 15: The Regulatory and Ethical Aspects of Drug Development
- Regulatory Agencies and Drug Approval Processes
- Clinical Trials: Phases and Methodology
- Ethics in Drug Development and Testing
- Intellectual Property and Patents in Medicinal Chemistry
Chapter 16: Future Trends in Medicinal Chemistry
- Advances in Targeted Therapy and Precision Medicine
- The Role of Artificial Intelligence in Drug Discovery
- Advances in Biopharmaceuticals and Gene Therapy
- Emerging Technologies in Drug Design
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