From Molecules to Networks An Introduction to Cellular and Molecular Neuroscience 1st Edition by Ruth Heidelberger, Neal Waxham, John Byrne, James Roberts ISBN 9780080491356 0080491359
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Authors:John H. Byrne; Ruth Heidelberger; M. Neal Waxham , Series:Anatomy [11] , Tags:Medical; Anatomy; Neurology; Science; Life Sciences; Human Anatomy & Physiology , Author sort:Byrne, John H. & Heidelberger, Ruth & Waxham, M. Neal , Ids:Google; 9780123971791 , Languages:Languages:eng , Published:Published:Apr 2014 , Publisher:Academic Press/Elsevier , Comments:Comments:An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. The third edition of From Molecules to Networks provides the solid foundation of the morphological, biochemical, and biophysical properties of nerve cells. In keeping with previous editions, the unique content focus on cellular and molecular neurobiology and related computational neuroscience is maintained and enhanced. All chapters have been thoroughly revised for this third edition to reflect the significant advances of the past five years. The new edition expands on the network aspects of cellular neurobiology by adding new coverage of specific research methods (e.g., patch-clamp electrophysiology, including applications for ion channel function and transmitter release; ligand binding; structural methods such as x-ray crystallography). Written and edited by leading experts in the field, the third edition completely and comprehensively updates all chapters of this unique textbook and insures that all references to primary research represent the latest results. * The first treatment of cellular and molecular neuroscience that includes an introduction to mathematical modeling and simulation approaches * 80% updated and new content * New Chapter on “Biophysics of Voltage-Gated Ion Channels” * New Chapter on “Synaptic Plasticity” * Includes a chapter on the Neurobiology of Disease * Highly referenced, comprehensive and quantitative * Full color, professional graphics throughout * All graphics are available in electronic version for teaching purposes
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ISBN 10: 0080491359
ISBN 13: 9780080491356
Author: Ruth Heidelberger, Neal Waxham, John Byrne, James Roberts
An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. This book provides the solid foundation of the morphological, biochemical, and biophysical properties of nerve cells that is needed by advanced undergraduates and graduate students, as well as researchers in need of a thorough reference.
* Highly referenced for readers to pursue topics of interest in greater detail
* Unique coverage of the application of mathematical modeling and simulation approaches not found in other textbooks
* Richly illustrated, four color presentation throughout
* Includes CD-ROM of all of the illustrations
From Molecules to Networks An Introduction to Cellular and Molecular Neuroscience 1st Edition Table of contents:
Chapter 1. Cellular Components of Nervous Tissue
The Neuron
The Neuroglia
The Cerebral Vasculature
Chapter 2. Subcellular Organization of the Nervous System: Organelles and Their Functions
Axons and Dendrites: Unique Structural Components of Neurons
Protein Synthesis in Nervous Tissue
The Cytoskeletons of Neurons and Glial Cells
Molecular Motors in the Nervous System
Building and Maintaining Nervous System Cells
Chapter 3. Brain Energy Metabolism
Energy Metabolism of the Brain as a Whole Organ
Tight Coupling of Neuronal Activity, Blood Flow, and Energy Metabolism
Energy-Producing and Energy-Consuming Processes in the Brain
Brain Energy Metabolism at the Cellular Level
Glutamate and Nitrogen Metabolism: A Coordinated Shuttle Between Astrocytes and Neurons
The Astrocyte–Neuron Metabolic Unit
Chapter 4. Electrotonic Properties of Axons and Dendrites
Spread of Steady-State Signals
Spread of Transient Signals
Electrotonic Properties Underlying Propagation in Axons
Electrotonic Spread in Dendrites
Dynamic Properties of Passive Electrotonic Structure
Relating Passive to Active Potentials
Chapter 5. Membrane Potential and Action Potential
The Membrane Potential
The Action Potential
Chapter 6. Molecular Properties of Ion Channels
Families of Ion Channels
Channel Gating
Ion Permeation
Ion Channel Distribution
Summary
Chapter 7. Dynamical Properties of Excitable Membranes
The Hodgkin–Huxley Model
A Geometric Analysis of Excitability
Chapter 8. Release of Neurotransmitters
Organization of the Chemical Synapse
Excitation–Secretion Coupling
The Molecular Mechanisms of the Nerve Terminal
Quantal Analysis
Short-Term Synaptic Plasticity
Chapter 9. Pharmacology and Biochemistry of Synaptic Transmission: Classic Transmitters
Diverse Modes of Neuronal Communication
Chemical Transmission
Classic Neurotransmitters
Summary
Chapter 10. Nonclassic Signaling in the Brain
Peptide Neurotransmitters
Neurotensin as an Example of Peptide Neurotransmitters
Unconventional Transmitters
Synaptic Transmitters in Perspective
Chapter 11. Neurotransmitter Receptors
Ionotropic Receptors
G Protein-Coupled Receptors
Chapter 12. Intracellular Signaling
Signaling Through G-Protein-Linked Receptors
Modulation of Neuronal Function by Protein Kinases and Phosphatases
Chapter 13. Regulation of Neuronal Gene Expression and Protein Synthesis
Intracellular Signaling Affects Nuclear Gene Expression
Role of cAMP and Ca2+ in the Activation Pathways of Transcription
Summary
Chapter 14. Mathematical Modeling and Analysis of Intracellular Signaling Pathways
Methods for Modelling Intracellular Signaling Pathways
General Issues in the Modeling of Biochemical Systems
Specific Modeling Methods
Summary
Chapter 15. Cell–Cell Communication: An Overview Emphasizing Gap Junctions
Chemical and Electrical Synapses Differ in Functional Characteristics
Biophysical and Pharmacological Properties of Gap Junctions in the Nervous System
Role of Gap Junctions in Functions of Nervous Tissue
Gap Junction-Related Neuropathologies
Chapter 16. Postsynaptic Potentials and Synaptic Integration
Ionotropic Receptors: Mediators of Fast Excitatory and Inhibitory Synaptic Potentials
Metabotropic Receptors: Mediators of Slow Synaptic Potentials
Integration of Synaptic Potentials
Chapter 17. Information Processing in Complex Dendrites
Strategies for Studying Complex Dendrites
Summary: The Dendritic Tree as a Complex Information Processing System
Chapter 18. Learning and Memory: Basic Mechanisms
Long-Term Synaptic Potentiation and Depression
Paradigms Have Been Developed To Study Associative and Nonassociative Learning
Invertebrate Studies: Key Insights From Aplysia Into Basic Mechanisms of Learning
Classical Conditioning in Vertebrates: Discrete Responses and Fear as Models of Associative Learning
How Does a Change in Synaptic Strength Store Complex Memory?
Summary
Index
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