Free Radicals in ENT Pathology 1st edition by Josef Miller, Colleen le Prell, Leonard Rybak ISBN 3319377132 978-3319377131

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ISBN 10: 3319377132
ISBN 13: 978-3319377131
Author: Josef Miller, Colleen le Prell, Leonard Rybak

This comprehensive volume examines the current state of free radical biology and its impact on otology, laryngology, and head and neck function. The chapters collectively highlight the interrelationship of basic and translational studies in each area, define the challenges to translation, and identify the existing basic issues that demand investigation as well as the opportunities for novel intervention to prevent and treat ENT pathology and impairment. In each chapter, or in some cases pairs of chapters, the author(s) have included or married issues of basic research with translational challenges and research, thus defining the pathway by which new basic insights may lead to interventions to prevent or treat impairment. The final chapter of this book reflects a meeting of all the contributors, culminating in a discussion and “white paper” that identifies the challenges to the field and defines the studies and collaborations that may lead to improved understanding of free radical biology in ENT and, subsequently,  new interventions to medically treat ENT pathology.

Free Radicals in ENT Pathology 1st Table of contents:

Part I: Introduction to Free Radicals and Oxidative Stress

1. Basic Concepts of Free Radicals and Oxidative Stress
   • Definition of Free Radicals
   • Mechanisms of Free Radical Formation
   • Role of Oxidative Stress in Cellular Injury
   • Antioxidant Defense Systems in the Body
2. Free Radicals and Disease Pathogenesis
   • The Role of Free Radicals in Cellular Signaling
   • Free Radicals in Aging and Chronic Diseases
   • The Balance between Oxidants and Antioxidants in Health

Part II: Free Radicals in Ear Pathology

3. Free Radicals and Auditory Pathology
   • Mechanisms of Hearing Loss and Damage
   • The Role of Oxidative Stress in Cochlear Damage
   • Free Radicals in Noise-Induced Hearing Loss
   • Antioxidant Therapies in Hearing Preservation
4. Ototoxicity and Free Radicals
   • Ototoxic Drugs and Their Impact on Inner Ear Cells
   • Mechanisms of Ototoxic Injury Involving Free Radicals
   • Clinical Management and Prevention of Ototoxicity

Part III: Free Radicals in Nasal and Sinus Pathology

5. Oxidative Stress in Nasal and Sinus Infections
   • Role of Free Radicals in Chronic Rhinosinusitis
   • Free Radical-Induced Tissue Injury in Sinusitis
   • The Impact of Inflammation and Oxidative Stress on Nasal Mucosa
6. Free Radicals and Allergic Rhinitis
   • Oxidative Stress and the Pathophysiology of Allergic Reactions
   • The Role of Free Radicals in Nasal Epithelial Damage
   • Antioxidants in the Treatment of Allergic Rhinitis

Part IV: Free Radicals in Laryngeal Pathology

7. Free Radicals in Laryngeal Disorders
   • Role of Oxidative Stress in Laryngeal Cancer
   • Impact of Free Radicals in Vocal Cord Injury and Dysfunction
   • The Pathophysiology of Inflammatory Conditions in the Larynx
8. Oxidative Stress in Laryngeal Cancer
   • Molecular Mechanisms of Carcinogenesis in the Larynx
   • The Role of Free Radicals in Tumor Development and Progression
   • Potential Therapeutic Interventions Targeting Oxidative Stress

Part V: Free Radicals in Pharyngeal and Oral Pathology

9. Oxidative Stress and Pharyngeal Disorders
   • Free Radicals in the Pathogenesis of Pharyngitis and Tonsillitis
   • The Role of Oxidative Stress in Chronic Pharyngeal Inflammation
   • Free Radicals in Cancer of the Pharynx and Oral Cavity
10. Oral Pathology and Free Radicals
    • Mechanisms of Oral Mucosal Damage by Free Radicals
    • The Role of Oxidative Stress in Periodontal Disease
    • Free Radicals in Oral Cancer: Etiology and Prognosis

Part VI: Free Radicals and Surgical Pathology in ENT

11. Surgical Approaches in Reducing Oxidative Stress in ENT
    • Surgical Interventions and Free Radical Damage in ENT Pathologies
    • Role of Antioxidants in Post-Surgical Recovery
    • Minimizing Oxidative Damage During ENT Surgeries
12. Innovative Therapies and Antioxidant Strategies
    • Clinical Application of Antioxidants in ENT Disorders
    • Emerging Therapeutic Approaches to Combat Oxidative Stress
    • Future Directions in Antioxidant Therapy for ENT Diseases

Part VII: Diagnostic and Prognostic Aspects

13. Diagnostic Approaches to Oxidative Stress in ENT Pathology
    • Laboratory Techniques for Measuring Free Radicals
    • Biomarkers of Oxidative Damage in ENT Diseases
    • Imaging and Diagnostic Tools for Oxidative Stress in ENT
14. Prognostic Significance of Free Radicals in ENT Disorders
    • Correlation Between Free Radical Levels and Disease Severity
    • The Role of Oxidative Stress in Disease Progression and Outcome
    • Long-Term Monitoring of Oxidative Stress in ENT Pathology

Part VIII: Future Directions and Research in Free Radicals and ENT

15. Emerging Research on Free Radicals in ENT Pathology
    • New Insights into Oxidative Stress and Disease Mechanisms
    • Advances in Antioxidant Research in ENT Medicine
    • Clinical Trials and Future Prospects in Free Radical Therapy

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