Epidemiology Pathogenesis and Prevention of Head and Neck Cancer 1st Edition by Andrew Olshan ISBN 1441914722 9781441914729

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ISBN 10: 1441914722 
ISBN 13: 9781441914729
Author: Andrew Olshan

The purpose of this book is to provide a current perspective on the epidemiology head and neck cancer. Cancers of the oral cavity, pharynx, and larynx comprise an important group of tumors with diverse international patterns of incidence and mortality, established risk factors, suggested association with a virus, and potential genetic susceptibility determinants. These tumors offer a unique insight into mechanisms of cancer initiation and progression and gene-exposure interaction.

Epidemiology Pathogenesis and Prevention of Head and Neck Cancer 1st Table of contents:

Classification, Clinical Features, and Molecular Genetic Models
Traditional Concepts of Tumor Classification
Tumor Stage
Anatomical Categories
Histologic Features
Risk Factors
Nodal Basin Involvement
Molecular Biology Basics
Comparative Profiles of Phenotype and Genotype Contribute to Tumor Progression Models
Prognosis and Genetic Profile
Conclusion
References
Descriptive Epidemiology: U.S. Patterns
Abbreviations
Overview
Methods
Demographic Patterns
Incidence
Age-Specific Patterns
Time Trends
Mortality
Time Trends
Geographic Variation
Survival
Recent Patterns and Time Trends
Stage-Specific Patterns
Discussion
Acknowledgments
References
Descriptive Epidemiology: International Patterns
Sources of Data
Incidence Patterns
Trends
Histologic Distribution
Survival Experience
Implication
Acknowledgments
References
Risk Factors: Tobacco and Alcohol
Tobacco
Independent Effect
Dose Response
Age at Start of Tobacco Smoking
Cessation of Tobacco Smoking
Types of Tobacco
Involuntary Smoking
Marijuana Use
Alcohol
Independent Effect
Dose Response
Age at Start of Alcohol Drinking
Cessation of Alcohol Drinking
Types of Alcohol
Tobacco and Alcohol
Summary
References
Human Papillomavirus and Head and Neck Cancer
Human Papillomaviruses
Biology and Viral Transformation
Epidemiologic Classification as Oncogenic Types
Molecular Evidence for a Causal Role of HPV in Head and Neck Squamous Cell Carcinomas (HNSCCs)
Epidemiologic Evidence for a Causal Role of HPV in HNSCCs
HPV Exposure Measures
Evidence from Case–Control and Cohort Studies
Interaction of HPV with Other HNSCC Risk Factors
Epidemiologic Assessment of Causality for HPV in Oropharyngeal Cancer
Epidemiology of Oral HPV Infections
Clinical Features of HPV-Positive Head and Neck Cancers
Burden of HPV-Related Head and Neck Cancers
Prospects for Prevention of HPV-Associated Head and Neck Cancers
Populations at High Risk of HPV-Associated Head and Neck Cancer
Potential for Prevention of HPV-Associated Head and Neck Cancer Through Prophylactic HPV Vaccination
Conclusions and Future Directions
References
Dietary Factors
Cancer of the Oral Cavity and Pharynx
Introduction
Food Groups
Vegetables and Fruits
Meat, Fish, and Eggs
Cereals
Milk and Dairy Products
Tea, Coffee and Other Hot Drinks
Nutrients and Other Food Components
Micronutrients
Flavonoids
Fats
Fibers
Cancer of The Larynx
Introduction
Food Groups and Hot Drinks
Vegetables and Fruits
Other Foods and Beverages
Nutrients and Other Food Components
Micronutrients
Flavonoids
Macronutrients
Conclusions
References
Occupation and Other Risk Factors for Head and Neck Cancer
Introduction
SCCHN and Occupation
Gastroesophageal Reflux
Oral Health and SCCHN
Conclusions
References
Host Susceptibility and Molecular Epidemiology
Genetic Susceptibility
Familial Aggregation of SCCHN Cancer
Metabolic Polymorphisms
Mutagen Sensitivity as a Marker of Risk
DNA Repair Phenotype as a Marker of Risk
DNA Repair Gene Polymorphisms
Polymorphisms of Genes Involved in One-Carbon Metabolic Pathway
Polymorphisms of Genes Involved in Cell Cycle Control and Apoptosis
Risk Prediction Model and Genome-Wide Association Studies
References
Chemoprevention of Head and Neck Cancers
Introduction
Risk Assessment
Oral Leukoplakia/Erythroplakia and Cancer Risk
Molecular Markers of Cancer Risk
Chromosomal Allelic Imbalances
Cyclin D1
Chemoprevention Clinical Trials
Clinical Trials for Premalignant Lesions
Clinical Trials for Prevention of Second Primary Tumors

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