Eosinophil Ultrastructure Atlas of Eosinophil Cell Biology and Pathology 1st edition by Peter Weller,Rossana Melo,Ann Dvorak 9780128137567 0128137568
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Authors:Rossana C.N. Melo;Ann M. Dvorak;Peter F. Weller; , Series:Pathology [314] , Author sort:Weller;, Rossana C.N. Melo;Ann M. Dvorak;Peter F. , Ids:9780128137550 , Languages:Languages:eng , Published:Published:Apr 2011 , Publisher:Elsevier
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ISBN 10: 0128137568
ISBN 13: 9780128137567
Author:Peter Weller,Rossana Melo,Ann Dvorak
Eosinophil Ultrastructure: Atlas of Eosinophil Cell Biology and Pathology entirely focuses on eosinophils and their functional roles in inflammation, host defense, and normal homeostatic activities. The book explores the ultrastructure of human eosinophils, highlighting biological processes observed under normal, experimental, and pathological conditions.
Created to fill a void in the eosinophil literature, the book includes an extensive array of electron microscopic images that illustrate the diversity of eosinophil morphology. While the atlas is a learning and teaching tool, it is mainly a helpful resource for researchers to identify distinguishing features and structural changes that arise during studies of human eosinophils.
The book also covers the ultrastructure of mouse eosinophils under normal and activation conditions and in the context of representative diseases.
- Gives guidelines to understand the human eosinophils in studies focused on structural biology, cellular immunology, innate and adaptive immunity, immune responses to pathogens, immunopathology, and inflammatory responses
- Provides a core of essential knowledge to identify both immature and mature eosinophils
- Comprises a representative compilation of the eosinophil ultrastructure during biological processes, such as activation and degranulation, mostly under experimental conditions
- Highlights eosinophil biological processes found in vivo during human diseases, thus providing a link between basic science and clinical aspects
- Helps identify distinguishing features and structural changes that arise during studies of human eosinophils after isolation from body fluids, while in cultures, or biopsies
- Explains the ultrastructural organization of mature and immature mouse eosinophils, highlighting the similarities/differences between them and human eosinophils
Eosinophil Ultrastructure Atlas of Eosinophil Cell Biology and Pathology 1st Table of contents:
Section A: The cell biology of human eosinophils
Chapter 1: Introduction
Abstract
References
Chapter 2: Mature eosinophils: General morphology
Abstract
2.1: Overview
2.2: Nucleus
2.3: Secretory granules
2.4: Lipid bodies (LBs)
2.5: Eosinophil sombrero vesicles (EoSVs)
2.6: Other organelles and structures
References
Chapter 3: Eosinophils as secretory cells
Abstract
3.1: Overview
3.2: Classical and compound exocytosis
3.3: Piecemeal degranulation
3.4: Cytolysis
3.5: Extracellular vesicle production
References
Chapter 4: Eosinophil activation
Abstract
4.1: Overview
4.2: Ultrastructural changes of secretory granules
4.3: EoSV formation
4.4: Lipid body formation
4.5: Shape changes
4.6: Release of extracellular vesicles (EVs)
References
Chapter 5: Subcellular localization of immune mediators and other proteins
Abstract
5.1: Overview
5.2: Major basic protein (MBP)
5.3: Cytokines
5.4: Receptors
5.5: Tetraspanins
5.6: Galectin-10 (Gal-10)
5.7: Enzymes involved in the formation of leukotrienes
References
Chapter 6: Eosinophil cell death
Abstract
6.1: Overview
6.2: Cytolytic morphology: General aspects
6.3: Cytolytic morphology: ETosis
6.4: Apoptotic morphology: General aspects
References
Chapter 7: Immature eosinophils
Abstract
7.1: Overview
7.2: About immature and mature eosinophil granules
7.3: Maturation stages of human eosinophils characterized by TEM
References
Section B: Eosinophils in human diseases
Chapter 8: Eosinophil-associated diseases (EADs)
Abstract
8.1: Overview
8.2: Allergic airway diseases
8.3: Skin disorders
8.4: Hypereosinophilic syndromes (HESs)
8.5: Eosinophilic granulomatosis with polyangiitis (EGPA)
8.6: Gastrointestinal disorders
8.7: Infectious diseases
8.8: Tumors
8.9: Ultrastructure of CLCs in eosinophilic diseases
References
Section C: The cell biology of mouse eosinophils
Chapter 9: Ultrastructure of mouse eosinophils
Abstract
9.1: Overview
9.2: Mature mouse eosinophils: General morphology
9.3: Immature mouse eosinophils
9.4: Activation and degranulation of mouse eosinophils
9.5: Mice in the context of EADs
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