Endocannabinoids 1st edition by Roger Pertwee ISBN 3319208241 978-3319208244

1. Introduction

General introduction to the Endocannabinoid System (ECS), which plays a critical role in regulating various physiological processes like pain, appetite, mood, and memory.

2. Evidence That Certain Endogenous Compounds Target Cannabinoid Receptors Orthosterically

Explores the endogenous cannabinoids and how they bind to cannabinoid receptors (CB1, CB2).

Includes evidence from binding assays and functional bioassays (e.g., [35S]GTPgammaS and cyclic AMP assays).

3. Non-Cannabinoid Receptors and Channels Targeted by Endocannabinoid Ligands

Discusses non-cannabinoid receptors and channels that can also interact with ECS ligands, such as:

GPR55, a G protein-coupled receptor (GPCR).

Ligand-gated ion channels like 5-HT3 receptors, nicotinic acetylcholine receptors, glycine receptors, and NMDA receptors.

Transient Receptor Potential (TRP) channels including TRPV1 and TRPM8.

Voltage-gated calcium channels, potassium channels (e.g., KATP channels), and more.

4. Allosteric Endocannabinoids

Focus on the role of allosteric modulation by certain endogenous compounds in ECS function.

5. Conclusions

Summary and synthesis of the evidence regarding ECS interactions with various receptors and channels.