Elements of Molecular Neurobiology 3rd edition by Smith – Ebook PDF Instant Download/Delivery. 0471560383, 978-0471560388
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Product details:
ISBN 10: 0471560383
ISBN 13: 978-0471560388
Author: Smith
This edition of the popular text incorporates recent advances in neurobiology enabled by modern molecular biology techniques. Understanding how the brain works from a molecular level allows research to better understand behaviours, cognition, and neuropathologies. Since the appearance six years ago of the second edition, much more has been learned about the molecular biology of development and its relations with early evolution. This “evodevo” (as it has come to be known) framework also has a great deal of bearing on our understanding of neuropathologies as dysfunction of early onset genes can cause neurodegeneration in later life. Advances in our understanding of the genomes and proteomes of a number of organisms also greatly influence our understanding of neurobiology.
* Well known and widely used as a text throughout the UK, good reviews from students and lecturers.
* Good complement to Fundementals of Psychopharmacology by Brian Leonard.
This book will be of particular interest to biomedical undergraduates undertaking a neuroscience unit, neuroscience postgraduates, physiologists, pharmacologists.
It is also a useful basic reference for university libraries.
Maurice Elphick, Queen Mary, University of London
“I do like this book and it is the recommended textbook for my course in Molecular Neuroscience. The major strength of the book is the overall simplicity of the format both in terms of layout and diagrams.”
Elements of Molecular Neurobiology 3rd Table of contents:
Chapter 1: Introduction to Molecular Neurobiology
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The Nervous System: An Overview
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Structure and Function of Neurons
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Molecular Basis of Neurobiology
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Key Concepts: Genes, Proteins, and Cellular Signaling
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The Role of Molecular Neurobiology in Neuroscience
Chapter 2: Molecular Structure of the Nervous System
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Cellular Architecture of the Brain and Nervous System
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Neurons, Glia, and Synapses
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The Blood-Brain Barrier: Structure and Function
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Intracellular Organelles and Their Roles in Neuronal Function
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The Cytoskeleton in Neuronal Structure and Movement
Chapter 3: Ion Channels and Membrane Potential
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The Biophysics of the Cell Membrane
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Ion Channels: Types and Functions
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Resting Membrane Potential and Its Regulation
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Action Potential Generation and Propagation
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Ionic Basis of Excitability: Sodium, Potassium, Calcium, and Chloride Ions
Chapter 4: Neurotransmission and Synaptic Signaling
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Neurotransmitters: Types and Synthesis
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Mechanisms of Neurotransmitter Release
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Ionotropic vs. Metabotropic Receptors
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Synaptic Plasticity and Long-Term Potentiation
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The Role of Second Messengers in Synaptic Signaling
Chapter 5: Molecular Mechanisms of Synaptic Transmission
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Synaptic Vesicle Cycle: From Fusion to Recycling
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SNARE Proteins and Their Role in Vesicle Exocytosis
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Synaptic Receptor Desensitization and Resensitization
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G-Protein Coupled Receptors (GPCRs) and Their Pathways
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Modulation of Synaptic Activity
Chapter 6: Signal Transduction Pathways in Neurons
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Overview of Signal Transduction in Neurons
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The Role of Kinases and Phosphatases in Signaling
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cAMP and Phosphoinositide Signaling Pathways
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MAP Kinase and PI3K Pathways
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Integration of Intracellular Signaling for Cellular Responses
Chapter 7: Molecular Basis of Learning and Memory
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The Neurobiology of Learning
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Molecular Mechanisms Underlying Memory Formation
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Long-Term Potentiation (LTP) and Long-Term Depression (LTD)
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Role of Protein Synthesis in Synaptic Plasticity
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Molecular Pathways of Memory Consolidation
Chapter 8: Development of the Nervous System
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Neuronal Differentiation and Migration
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Synaptogenesis and Synaptic Refinement
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The Role of Growth Factors in Neurodevelopment
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Axon Guidance and Targeting
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Neurogenesis in the Adult Brain
Chapter 9: Neurodegenerative Diseases: Molecular Mechanisms
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Alzheimer’s Disease: Amyloid and Tau Pathology
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Parkinson’s Disease: Dopamine, α-Synuclein, and Mitochondrial Dysfunction
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Huntington’s Disease: Genetic and Molecular Pathogenesis
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Amyotrophic Lateral Sclerosis (ALS): Molecular Insights
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Molecular Approaches to Understanding Neurodegeneration
Chapter 10: Molecular Basis of Brain Disorders
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The Molecular Pathology of Schizophrenia
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Molecular Mechanisms of Depression and Anxiety
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Autism Spectrum Disorders: Genetic and Molecular Insights
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Bipolar Disorder: Neurochemical and Molecular Pathways
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Addiction and Neuroplasticity: The Molecular Underpinnings
Chapter 11: The Blood-Brain Barrier and Molecular Transport
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Structure and Function of the Blood-Brain Barrier
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Molecular Mechanisms of Transport Across the Blood-Brain Barrier
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Strategies for Targeting the Brain with Therapeutic Agents
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Implications of the Blood-Brain Barrier in Drug Delivery
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Endothelial Cell Biology in the Blood-Brain Barrier
Chapter 12: Neuroimmune Interactions
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The Role of the Immune System in the Brain
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Microglia: The Brain’s Resident Immune Cells
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Neuroinflammation and Its Role in Neurological Diseases
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The Blood-Brain Barrier and Immune Cell Infiltration
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Modulating the Immune System for Neuroprotection
Chapter 13: Molecular Tools in Neurobiology
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Techniques for Studying Molecular Neurobiology
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Gene Editing and Knockout Models in Neuroscience
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Optical and Electrical Tools for Neuroscience Research
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Proteomics and Mass Spectrometry in Neurobiology
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Imaging Techniques for Studying Neuronal Function
Chapter 14: Advances and Future Directions in Molecular Neurobiology
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The Emerging Field of Neurogenomics
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Advances in Stem Cell Therapy for Neurodegenerative Diseases
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The Role of Artificial Intelligence in Neuroscience Research
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Personalized Medicine and Neurobiology
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Future Challenges and Opportunities in Molecular Neurobiology
Appendices
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A. Glossary of Key Terms in Molecular Neurobiology
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B. Molecular Neurobiology Resources: Databases and Tools
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C. Protocols for Neurobiological Experiments
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D. Further Reading and References
Index
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Subject Index
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Author Index
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