(Ebook PDF) Radiotheranostics A Primer for Medical Physicists I Physics Chemistry Biology and Clinical Applications 1st edition by Cari Borrás, Michael G Stabin 1003836100 9781003836100 full chapters

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ISBN-10 ‏ : ‎1003836100 

ISBN-13 ‏ : ‎ 9781003836100

Author :  Cari Borrás, Michael G. Stabin 

This book covers scientific, clinical, and educational aspects of radiotheranostics in cancer control. Setting the framework, the first volume defines radiotheranostics and describes the history of radionuclide therapy and theranostics, and the biology of cancer. It examines the clinical applications of unconjugated radionuclides, such as ¹³¹I and ²²³Ra, and of radionuclide-conjugated cancer-specific vectors: peptides, small molecules, antibodies, and nanoparticles; introduces clinical trials and drug development; and reviews epidemiological studies and the adverse effects of radionuclide therapy – both radiation injuries and chemical toxicity. 

 Radiotheranostics – A Primer for Medical Physicists I; Physics, Chemistry, Biology and Clinical Applications 1st Table of contents:

Part 1: Introduction
1 What Is Radiotheranostics?
1.1 Definitions
1.2 Scope
1.3 Radiotheranostic Pairs
1.4 The Need for Patient-Individualized Dosimetry in Radionuclide Therapy
1.5 Conclusion
References
2 History of Radionuclide Therapy and Theranostics
2.1 Introduction
2.2 Röntgen, Becquerel, and the Curies
2.3 The Curie Institute and Other Early Uses of Radionuclide Therapy
2.4 Advances in Physics in the 1930s
2.5 Saul Hertz and the Birth of Radioiodine Therapy
2.6 Radionuclide Therapy since Saul Hertz, Theranostics and the Future
2.7 Conclusion
References
3 Biological Principles behind Targeted Radionuclide Therapy for Cancer
3.1 A Brief Introduction to Biology of Cancer and Cancer Metastasis
3.2 Targeting Mechanisms in Radionuclide Therapy
3.3 Molecular Targets for Targeted Radionuclide Therapy
3.4 Specialized Targeting Mechanisms in Radionuclide Therapy – Examples
3.5 Conclusion
References
Part 2 Clinical Applications of Targeted Radionuclide Therapy in Cancer Control
4 Unconjugated Radionuclides
4.1 Radioiodine Therapy (131I) for Differentiated Thyroid Cancer
4.2 Unconjugated Radionuclides for Bone Therapy
4.3 Unconjugated Radionuclides for Selective Internal Radiation Therapy in Liver Tumors
References
5 Radionuclide-Conjugated Cancer-Specific Vectors: Peptides
5.1 Introduction
5.2 Peptides
5.3 Somatostatin, Somatostatin Receptors, Somatostatin Analogs, and Somatostatin Antagonists
5.4 Radionuclides for PRRT
5.5 Neuroendocrine Tumors
5.6 Peptide Receptor Radionuclide Therapy
5.7 Future Perspective in PRRT
5.8 Dosimetric Aspects in PRRT
References
6 Radionuclide-Conjugated Cancer Specific Vectors: Small Molecules and Antibodies
6.1 Introduction
6.2 Radiolabeled Small Molecules
6.3 Radiolabeled Antibodies
6.4 Conclusion
References
7 Radionuclide-Conjugated Cancer-Specific Vectors: Nanoparticles
7.1 Introduction
7.2 Why Nanoparticles?
7.3 Radionuclide Nanoparticle Formulations
7.4 Biodistribution
7.5 Conclusion
References
8 Introduction to Clinical Trials and Drug Development for Radionuclide Therapies
8.1 Introduction
8.2 Preclinical Studies
8.3 IND Application/Approval
8.4 Phase I Clinical Trials
8.5 Phase II Clinical Trials
8.6 Phase III Clinical Trials
8.7 Key Phase III Trials
8.8 Additional Trials
8.9 RNT Imaging and Dosimetry
8.10 Unique Aspects of RNT Clinical Trials
8.11 Conclusion
8.12 Disclosures
References
9 Epidemiologic Studies of Cancer Risk among Patients Administered Radionuclides
9.1 Introduction
9.2 Epidemiologic Studies
9.3 Current Therapy with Radiopharmaceuticals
9.4 Conclusions
References
10 Adverse Effects of Radionuclide Therapy
10.1 Introduction
10.2 Acute Toxicities
10.3 Subacute Toxicities
10.4 Late Toxicities
10.5 Extravasation
References
Part 3 Radiation Chemistry and Physics
11 Radionuclide Production
11.1 Introduction
11.2 Production
11.3 Production via Neutron Capture
11.4 Cyclotron-Produced Radionuclides
11.5 Radionuclides Produced via Different Methods
11.6 Radionuclide Generators (Parent/Daughter Pairs for Both Diagnostic and Therapeutic Radionuclides)
11.7 Radiochemistry
11.8 Conclusion
Acknowledgments
References
12 Radioactivity Measurement and Traceability
12.1 Introduction
12.2 Primary Standards of Radioactivity
12.3 Radionuclide Calibrators
12.4 Activity Measurements for Radiotheranostics
12.5 Conclusion
Funding Acknowledgment
References
13 Instrumentation, Calibration, Quantitative Imaging, and Quality Control
13.1 Introduction
13.2 Instrumentation
13.3 Tomographic Reconstruction
13.4 Problems Related to Quantitative Imaging
13.5 Quality Control
13.6 Image Quality Parameters
13.7 Activity Measurement
13.8 Conclusion
References
Part 4 The Future
14 Human Resources: Multidisciplinary Team Education, Training, and Competence
14.1 Introduction
14.2 Scaffolding Themes in Multidisciplinary Team Education
14.3 General Competency Requirements
14.4 General Registration, Specialized Training, and Accreditation for Multidisciplinary Team
14.5 Theranostics Core Competencies
14.6 Advancing Theranostics Competence for Nuclear Medicine Physicians and Oncologists
14.7 Advancing Theranostics Competence for Medical Physicists
14.8 Quality Assurance in Theranostic Service Delivery
14.9 Radiation Safety in Theranostic Service Delivery
14.10 Advancing Theranostics Competence for the Nuclear Medicine Technologist (NMT)
14.11 Conclusion
References
15 Theranostics Today: Looking Backwards to Tomorrow
15.1 The Current Role of Molecular Radionuclide Therapy and Theranostics
15.2 Types of Radiation and Theranostic Radionuclide Pairs
15.3 The Medical Physics Toolkit for Radiotheranostics
15.4 The Next Challenge: Precision Theranostics
15.5 The Future

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