Drug Induced Liver Toxicity 1st edition by Minjun Chen, Yvonne Will ISBN 1493976761 978-1493976768

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Product details:

ISBN 10: 1493976761 
ISBN 13: 978-1493976768
Author: Minjun Chen, Yvonne Will 

This book provides a comprehensive view of the methodologies used for the study of liver toxicity encountered throughout the whole life cycle of a drug, from drug discovery, to clinical trial, post-marketing, and even clinical practice. Organized into six sections, the first section introduces the mechanisms contributing to drug-induced liver toxicity. The second and third section explore in silico and in vitro approaches used to help mitigate hepatotoxicity liability at the early stages of drug development. The fourth section describes methodologies applied in regulatory processes, including preclinical studies, clinical trials, and post-marketing surveillance. The fifth section discusses clinical hepatotoxicity. Emerging technologies are examined in the final section. As a volume in the Methods in Pharmacology and Toxicology series, chapters include the kind of expert advice that will lead to optimal results.
Authoritative and practical, Drug-InducedLiver Toxicity serves all those who aim to improve assessment and understanding of hepatotoxic potentials of new medications and marketed drugs.

Drug-Induced Liver Toxicity 1st Table of contents:

• Mechanisms of Drug-Induced Liver Injury: The book delves into how drugs or their metabolites can cause damage to liver cells, impair liver function, and contribute to pathogenesis. It explores oxidative stress, immune response, mitochondrial dysfunction, and cellular injury as primary pathways.

• Preclinical Assessment: It provides insight into the methods used to assess the potential of drugs to cause liver toxicity in preclinical phases of drug development. These methods include animal models, biomarkers, and histological examination.

• Clinical Presentation and Diagnosis: The authors address how drug-induced liver toxicity presents in clinical settings, discussing symptoms, biomarkers, and diagnostic criteria. This helps clinicians identify liver injury early and intervene appropriately.

• Management and Treatment: The book also covers the therapeutic approaches to managing drug-induced liver damage, including the use of specific antidotes, liver transplantation, and supportive care.

• Case Studies and Examples: Practical case studies and examples of well-known drugs that have caused liver toxicity are provided, along with analyses of their mechanisms and clinical implications.

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