Diagnostic Pathology of Hematopoietic Disorders of Spleen and Liver 1st editon by Ling Zhang, Haipeng Shao, Serhan Alkan ISBN 3030377075 978-3030377076

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ISBN 10: 3030377075  
ISBN 13: 978-3030377076
Author: Ling Zhang, Haipeng Shao, Serhan Alkan

This book provides a comprehensive and up-to-date overview of the pathologic features of common benign and malignant hematopoietic disorders in spleen and liver for practicing pathologists, hematopathologists and clinicians. The authors are from large academic centers, affiliated teaching hospitals and central referral clinics and are experienced in the diagnosis of hematopoietic disorders in the spleen and liver. The book consists of 21 chapters, with the first three chapters devoted to normal histologic features, conventional, cytogenetic and molecular studies necessary for the diagnosis of hematopoietic disorders in the spleen and liver. Chapters 4 to 17 cover the primary and secondary mature B- and T/NK cell lymphomas, Hodgkin lymphoma, B and T cell lymphoblastic leukemias, myeloid neoplasms, histiocytic and dendritic neoplasms, and post-transplant disorders including post transplant lymphoproliferative disorders. Chapters 19 to 21 encompass red blood cell disorders, other benign hematologic disorders and infectious/inflammatory disorders that could mimic hematopoietic neoplasms. These chapters are formatted on specific hematopoietic neoplasms to comprise epidemiology, etiology, pathogenesis, morphology, immunophenotyping, molecular genetics, prognosis and brief treatment guidelines. Diagnostic caveats are included in order to have a quick review of the key points in each chapter.

Diagnostic Pathology of Hematopoietic Disorders of Spleen and Liver covers most, if not all of the benign and malignant hematopoietic disorders in the spleen and liver and serves as a practical and useful resource for general pathologists and hematopathologists.

Diagnostic Pathology of Hematopoietic Disorders of Spleen and Liver 1st Table of contents:

• Introduction to Hematopoietic Disorders

  • Overview of hematopoiesis and its role in normal physiology.
  • Hematopoietic tissues: bone marrow, spleen, liver, and lymph nodes.
  • Basic pathology techniques in hematopoietic disorder diagnosis.

• Normal Spleen and Liver Histology

  • Structure and function of the spleen and liver in relation to hematopoiesis.
  • Vascular supply and lymphatic drainage.
  • The role of these organs in filtering blood and immune response.

• Spleen Pathology in Hematopoietic Disorders

  • Primary spleen disorders: splenomegaly, lymphoma, and splenic infarction.
  • Secondary spleen involvement in hematopoietic diseases: leukemia, lymphoproliferative disorders.
  • Pathophysiological mechanisms affecting the spleen in hematologic disorders.

• Liver Pathology in Hematopoietic Disorders

  • The role of the liver in hematopoiesis and immune response.
  • Hepatic involvement in blood diseases: cirrhosis, portal hypertension, and hematopoietic malignancies.
  • Liver diseases secondary to hematologic disorders like leukemia, lymphoma, and myeloproliferative disorders.

• Hematologic Malignancies and Their Impact on the Spleen and Liver

  • Acute and chronic leukemia and their effects on the spleen and liver.
  • Lymphomas: Hodgkin and non-Hodgkin lymphoma in relation to the spleen and liver.
  • Myeloproliferative disorders: effects of polycythemia vera, myelofibrosis, and essential thrombocythemia.

• Non-Malignant Hematologic Conditions Involving the Spleen and Liver

  • Hemolytic anemias, thalassemia, and sickle cell disease.
  • Splenic and hepatic manifestations of immune-related hematologic conditions.
  • Hemochromatosis, splenomegaly, and thrombocytosis.

• Diagnostic Approaches to Hematopoietic Disorders of Spleen and Liver

  • Imaging techniques: ultrasound, CT, MRI, and nuclear medicine in the evaluation of the spleen and liver.
  • Biopsy and cytology techniques: aspiration, core biopsy, and histopathology.
  • Laboratory tests for hematologic conditions affecting the spleen and liver (e.g., blood counts, liver function tests, bone marrow biopsies).

• Emerging Diagnostic Techniques in Hematopoietic Pathology

  • Molecular pathology and genetic testing in diagnosing hematologic disorders.
  • Flow cytometry and immunophenotyping in lymphoma and leukemia diagnostics.
  • Advances in imaging technologies and their applications.

• Case Studies and Clinical Correlations

  • Case-based discussions illustrating common and uncommon presentations of hematopoietic disorders involving the spleen and liver.
  • Integrating clinical, histological, and laboratory findings.
  • Diagnostic challenges in hematologic pathology.

• Treatment and Prognosis of Hematopoietic Disorders Affecting the Spleen and Liver

  • Treatment options for disorders affecting the spleen and liver, including chemotherapy, radiation, and organ transplantation.
  • Prognostic factors and outcomes in hematologic malignancies with organ involvement.
  • Emerging therapies and precision medicine in the treatment of hematopoietic disorders.

• Special Topics in Hematopoietic Disorders and Organ Involvement

  • Hematopoietic stem cell transplantation and its effects on the spleen and liver.
  • The role of the spleen and liver in bone marrow recovery.
  • Autoimmune diseases and their impact on hematopoietic tissues.

• Conclusion

  • Summary of key points in diagnosing and managing hematopoietic disorders with splenic and hepatic involvement.
  • Future directions in the pathology of hematopoietic disorders.

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