Diagnostic Pathology Neuropathology 2nd edition by Kleinschmidt DeMasters, Fausto Rodriguez, Tarik Tihan ISBN 0323445926 ‎ 978-0323445924

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ISBN 10: 0323445926 ‎ 
ISBN 13: ‎ 978-0323445924
Author: Kleinschmidt DeMasters, Fausto Rodriguez, Tarik Tihan 

Part of the highly regarded Diagnostic Pathology series, Diagnostic Pathology: Neuropathology is a visually stunning, easy-to-use reference covering all aspects of neuropathology. Nearly 1,700 outstanding images, including a wide variety of pathology stains and high-quality medical illustrations, make this an invaluable diagnostic aid for every practicing pathologist, resident, or fellow. This second edition incorporates the most recent clinical, pathological, histological, and molecular knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice.

• Expert Consult eBook version included,whichallows you to search all of the text, figures, and references from the book on a variety of devices.
• Thoroughly updated content throughout includes new biomarkers and genetic markers; new diagnostic, therapeutic, and prognostic techniques; new entities and antibodies; new immunohistochemical markers; the new “integrated” diagnosis schema; and much more.
• Features exclusive images not found in the 2016 updated WHO Classification system of CNS neoplasms.
• Presents complete information on lesions of the brain, sellar region, and peripheral nerves, as well as benign cysts and selected infectious, inflammatory, reactive, vascular, and cortical dysplastic lesions.
• High-quality, carefully annotated color images (both common and rare) depict classic pathological features as well as variant patterns that are prone to creating diagnostic problems.
• Time-saving reference features include bulleted text, a variety of test data tables, key facts in each chapter, annotated images, and an extensive index.

• Steriotactic biopsy for the diagnosis of small lesions

Diagnostic Pathology: Neuropathology 2nd Table of contents:

Part I: Introduction to Neuropathology

1. Overview of Neuropathology
   • Definition and Scope of Neuropathology
   • Historical Development and Milestones in Neuropathology
   • The Role of Neuropathology in Clinical Practice
2. Basic Neuroanatomy and Neurophysiology
   • Structure and Function of the Central and Peripheral Nervous Systems
   • Overview of Neurons, Glia, and Synapses
   • Blood-Brain Barrier and Cerebrospinal Fluid Dynamics

Part II: Mechanisms of Neurological Diseases

3. Cellular and Molecular Mechanisms in Neurological Disorders
   • Mechanisms of Neurodegeneration
   • Genetic and Epigenetic Factors in Neurological Diseases
   • Role of Inflammation and Immune Response in the Nervous System
4. Vascular Pathology in the Brain
   • Pathology of Cerebral Blood Vessels: Aneurysms, Strokes, and Arteriovenous Malformations
   • Ischemic and Hemorrhagic Cerebrovascular Diseases
   • Vascular Dementia and Microvascular Disease

Part III: Common Neuropathological Conditions

5. Neurodegenerative Diseases
   • Alzheimer’s Disease: Pathology, Diagnosis, and Mechanisms
   • Parkinson’s Disease and Other Movement Disorders
   • Huntington’s Disease and Amyotrophic Lateral Sclerosis (ALS)
   • Frontotemporal Dementia and Lewy Body Dementia
6. Stroke and Cerebral Ischemia
   • Pathology of Ischemic Stroke: Mechanisms and Histopathology
   • Hemorrhagic Stroke: Causes and Neuropathological Features
   • Reperfusion Injury and Stroke Recovery
7. Neoplastic Diseases of the Nervous System
   • Primary Brain Tumors: Gliomas, Meningiomas, and Medulloblastomas
   • Metastatic Tumors in the Brain and Spinal Cord
   • Diagnostic Approaches to Brain Tumor Classification
8. Infectious and Inflammatory Diseases
   • Viral Infections: HIV, Herpes Simplex Virus, and JC Virus
   • Bacterial, Fungal, and Parasitic Infections of the CNS
   • Multiple Sclerosis and Autoimmune Diseases of the Brain
9. Traumatic Brain Injury (TBI) and Spinal Cord Injury
   • Pathology of Concussions, Contusions, and Diffuse Axonal Injury
   • Chronic Traumatic Encephalopathy (CTE)
   • Spinal Cord Injury: Mechanisms and Neuropathological Changes
10. Epilepsy and Seizure Disorders
    • Structural Brain Changes in Epilepsy
    • Pathology of Focal and Generalized Seizures
    • Neuropathological Findings in Status Epilepticus

Part IV: Pathology of the Peripheral Nervous System

11. Peripheral Nerve Diseases
    • Neuropathies: Diabetic, Hereditary, and Inflammatory
    • Pathology of Nerve Damage: Axonal and Demyelinating Lesions
    • Guillain-Barré Syndrome and Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
12. Muscle and Neuromuscular Junction Disorders
    • Myopathies: Congenital and Acquired
    • Pathology of Myasthenia Gravis and Lambert-Eaton Myasthenic Syndrome
    • Neuropathology of Muscular Dystrophies

Part V: Diagnostic Methods in Neuropathology

13. Histopathological Techniques in Neuropathology
    • Tissue Preparation and Staining for Brain and Spinal Cord
    • Immunohistochemistry in Neuropathology
    • Electron Microscopy in the Diagnosis of Neurological Diseases
14. Molecular Pathology in Neuropathology
    • Genetic Testing in Neurological Diseases
    • Molecular Biomarkers in Neurodegeneration
    • Next-Generation Sequencing (NGS) in Neuropathology
15. Imaging in Neuropathology
    • MRI and CT in Neuroimaging: Interpretation of Findings
    • PET and SPECT Scanning for Neurological Disorders
    • Role of Functional Imaging in Brain Disease Diagnosis
16. Cytology and Fluid Analysis in Neuropathology
    • Cerebrospinal Fluid (CSF) Analysis
    • Cytology of Brain Tumors and Infections
    • Liquid Biopsy in Neurological Diseases

Part VI: Neuropathology in Special Populations

17. Neuropathology in Pediatric Populations
    • Congenital and Developmental Brain Disorders
    • Pediatric Brain Tumors and Malformations
    • Neurological Complications in Neonatal and Infant Populations
18. Neuropathology in Aging and the Elderly
    • Age-Related Neuropathological Changes
    • Neurological Disorders in the Elderly: Alzheimer’s Disease and Vascular Dementia
    • Neurodegenerative Diseases in Older Populations

Part VII: Advances and Future Directions in Neuropathology

19. Advances in Neuropathology: New Insights and Technologies
    • Advances in Imaging Modalities for Neuropathological Research
    • Emerging Genetic and Epigenetic Insights in Neurological Diseases
    • Role of Artificial Intelligence in Neuropathology
20. Therapeutic Approaches and Future Research Directions
    • Current and Emerging Treatments for Neurodegenerative Diseases
    • Gene Therapy and Stem Cell Approaches in Neurological Disorders
    • Future of Neuropathology in Precision Medicine

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