Diagnostic Pathology Molecular Oncology 2nd editon by Mohammad Vasef, Aaron Auerbach ISBN B07X517ZH5 978-0323611442

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ISBN 10: B07X517ZH5 
ISBN 13: 978-0323611442
Author: Mohammad Vasef, Aaron Auerbach 

Covering all aspects of molecular pathology as it relates to the transformation and pathogenesis of cancer, this award-winning volume in the Diagnostic Pathology series is an expert resource for pathologists at all levels of experience and training, both as a quick reference and as an efficient review to improve knowledge and skills. This easily accessible, point-of-care reference features templated, bulleted content that is generously illustrated with charts, graphs, tables, and color photomicrographs of histology with special stains. It offers a practical, clinical approach to examining how molecular mutations affect common medical diseases and identifies the relevant and appropriate molecular tests to perform for a complete work-up in the era of molecular-targeted therapies.

Diagnostic Pathology: Molecular Oncology 2nd Table of contents:

Section 1: Introduction to Molecular Oncology

1. Basic Concepts in Molecular Oncology

   • The Role of Molecular Pathology in Cancer Diagnosis

   • Genetic Alterations in Cancer

   • Principles of Molecular Diagnostic Techniques

2. Genetic and Epigenetic Changes in Cancer

   • Oncogenes and Tumor Suppressors

   • Mutations, Chromosomal Rearrangements, and Amplifications

   • DNA Methylation and Histone Modifications

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Section 2: Techniques in Molecular Pathology

3. Molecular Diagnostic Techniques

   • Polymerase Chain Reaction (PCR)

   • Fluorescence In Situ Hybridization (FISH)

   • Next-Generation Sequencing (NGS)

   • In Situ Hybridization and Immunohistochemistry

4. Tumor Profiling and Genomic Testing

   • Targeted Therapies Based on Molecular Profiles

   • Genomic Biomarkers in Cancer Diagnosis

   • Liquid Biopsy and ctDNA

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Section 3: Molecular Pathology of Specific Cancers

5. Breast Cancer

   • Genetic and Molecular Markers in Breast Cancer

   • HER2 Amplification and Hormone Receptor Status

   • Genomic Testing in Prognosis and Treatment

6. Lung Cancer

   • EGFR Mutations and ALK Rearrangements

   • Molecular Diagnostics in Small Cell and Non-Small Cell Lung Cancer

   • Personalized Medicine in Lung Cancer

7. Colorectal Cancer

   • Microsatellite Instability and Lynch Syndrome

   • KRAS, NRAS, and BRAF Mutations

   • Role of Molecular Testing in Treatment Decisions

8. Hematologic Malignancies

   • Genetic Alterations in Leukemia and Lymphoma

   • BCR-ABL Translocation in Chronic Myelogenous Leukemia (CML)

   • Molecular Diagnosis in Hodgkin and Non-Hodgkin Lymphoma

9. Gastrointestinal Cancers

   • Molecular Characteristics of Esophageal and Gastric Cancer

   • Mutations in Pancreatic Cancer

   • Molecular Pathology of Hepatocellular Carcinoma

10. Head and Neck Cancers

    • Human Papillomavirus (HPV) and Head and Neck Cancer

    • Molecular Testing in Thyroid Cancer

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Section 4: Emerging Topics in Molecular Oncology

11. Cancer Immunotherapy

    • Molecular Markers for Immunotherapy Response

    • Immune Checkpoint Inhibitors and Targeted Treatments

12. Personalized Medicine and Precision Oncology

    • Tailoring Treatment Based on Molecular Characteristics

    • The Role of Next-Generation Sequencing (NGS) in Personalized Oncology

13. Molecular Pathology in Clinical Practice

    • Integration of Molecular Pathology into Routine Diagnostic Workflows

    • Ethical and Practical Considerations in Molecular Diagnostics

    • Challenges in Implementing Molecular Pathology in Cancer Diagnosis

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Section 5: Future Directions in Molecular Oncology

14. Advances in Molecular Oncology

    • Emerging Techniques and Technologies in Molecular Pathology

    • The Role of Artificial Intelligence (AI) in Cancer Diagnosis

    • The Future of Liquid Biopsy and Tumor Profiling

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